The psychological significance of human startle eyeblink modification: a review
Biological PsychologyPublished 1 January 1998
Diane L. Filion, Michael E. Dawson, Anne M. Schell
Citations232
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TL;DR
This review provides a comprehensive survey of the current literature on human startle modification and its psychological significance and directions for future research are identified regarding both cognitive and emotional modification of startle.
Abstract
The human startle eyeblink reflex is reliably modified by both cognitive and emotional processes. This review provides a comprehensive survey of the current literature on human startle modification and its psychological significance. Issues raised for short lead interval startle inhibition include its interpretation as a measure of protection of processing, sensorimotor gating and early attentional processing. For long lead interval effects, interpretations related to attentional and emotional processing are discussed. Also reviewed are clinical applications to information processing dysfunctions in the schizophrenia spectrum disorders, and to emotional processing disorders. Finally, an integrative summary that incorporates most of the cognitive findings is presented and directions for future research are identified regarding both cognitive and emotional modification of startle.
Keywords
PsychologyNeuroscience
American PsychologistFeeling and thinking: Preferences need no inferences.
7,741 Citations1980Robert B. Zajonc
American PsychologistThe emotion probe: Studies of motivation and attention.
2,267 Citations1995Peter J. Lang
Psychological ReviewEmotion, attention, and the startle reflex.
2,118 Citations1990Peter J. Lang, Margaret M. Bradley +1 more
The startle response (an aversive reflex) is enhanced during a fear state and is diminished in a pleasant emotional context and the effect is found when affects are prompted by pictures or memory images, changes appropriately with aversive conditioning, and may be dependent on right-hemisphere processing.
Archives of General PsychiatrySensorimotor Gating and Schizophrenia
1,308 Citations1990David L. Braff
Human and animal model studies of sensorimotor gating allow investigators to comment on the spatial and temporal mapping of neurons, trait and state deficits, and vulnerability factors in the schizophrenic spectrum of disorders.
PsychophysiologyPrestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
1,178 Citations1978David Braff, C. Stone +4 more
When 20 normal subjects were compared to 12 schizophrenic subjects, significant differences in eyeblink response were found for blink amplitude and latency in the 60 msec prestimulus condition, which is consistent with information processing “overload” theories of sensory overstimulation in schizophrenia.
PsychophysiologyThe More or Less Startling Effects of Weak Prestimulation
1,129 Citations1975Frances K. Graham
It is proposed that, with the aid of physiological measures taken in the interval between lead and startle stimuli, this paradigm offers a promising method of investigating different levels of central processing and the operation of a short time-constant as opposed to a long time- constant system.
Archives of General PsychiatryGating and Habituation of the Startle Reflex in Schizophrenic Patients
1,035 Citations1992David L. Braff
The results indicate that schizophrenic patients have extensive deficits in both intramodal and cross-modal sensorimotor gating and a trend to show acoustic startle habituation deficits.
Journal of NeuroscienceA primary acoustic startle circuit: lesion and stimulation studies
971 Citations1982M. Davis, DS Gendelman +2 more
The data suggest that a primary acoustic startle circuit in the rat consists of auditory nerve, ventral cochlear nucleus, nuclei of the lateral lemniscus, nucleus reticularis pontis caudalis, spinal interneuron, lower motor neuron, and muscles.
Journal of Abnormal PsychologyPutatively psychosis-prone subjects 10 years later.
962 Citations1994Loren J. Chapman, Jean P. Chapman +3 more
The predictive validities of several indicators of psychosis proneness were evaluated in a 10-year longitudinal study and high scorers on the Perceptual Aberration Scale, Magical Ideation Scale, or both exceeded control subjects on psychoses, psychotic relatives, schizotypal symptoms, and psychoticlike experiences at follow up.
Psychology Press eBooksAttention and Orienting
797 Citations2013Peter J. Lang, Robert F. Simons +2 more
This chapter discusses the origins of Orienting and Defensive Responses, as well as studies of Attention, Affect, and Action in Child Development, and the Implications of Startle Modification.
PsychophysiologyEmotion and psychopathy: Startling new insights
767 Citations1994Christopher J. Patrick
Evidence is presented to demonstrate that the literature that indicates that criminal psychopaths do not show the expected potentiation of the startle reflex that normally occurs during processing of aversive stimuli such as unpleasant photographs or punishment cues is reviewed.
Journal of Abnormal PsychologyEmotion in the criminal psychopath: Startle reflex modulation.
742 Citations1993Christopher J. Patrick, Margaret M. Bradley +1 more
Journal of Abnormal PsychologyThe startle probe response: A new measure of emotion?
548 Citations1988Scott R. Vrana, Ellen L. Spence +1 more
Schizophrenia BulletinDevelopmental Processes in Schizophrenic Disorders: Longitudinal Studies of Vulnerability and Stress
466 Citations1992Keith H. Nuechterlein, Michael E. Dawson +6 more
The Developmental Processes in Schizophrenic Disorders project is a longitudinal study of schizophrenic patients who have recently had a first episode of psychosis and prospective data suggest that signs and symptoms prodromal to psychotic relapse may be present in about 60 percent of patients.
PsychophysiologyFear‐Potentiated Startle in Humans: Effects of Anticipatory Anxiety on the Acoustic Blink Reflex
457 Citations1991Christian Grillon, Rezvan Ameli +3 more
The results indicate that anticipatory anxiety can be measured objectively in humans using the fear-potentiated startle reflex in a paradigm not actually requiring any shock.
Brain Research BulletinStartle response models of sensorimotor gating and habituation deficits in schizophrenia
456 Citations1990Mark A. Geyer, Neal R. Swerdlow +2 more
Evidence is presented supporting the involvement of mesolimbic dopaminergic systems in the modulation of prepulse inhibition or sensorimotor gating and the importance of central serotonergic systemsIn the habituation of startle.
Journal of Neurology Neurosurgery & PsychiatryImpaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.
451 Citations1995Neal R. Swerdlow, Jane S. Paulsen +4 more
PPI was measured in patients with Huntington's disease to quantify and characterise sensorimotor gating and are consistent with preclinical findings that identify the striatum and striatopallidal GABAergic efferent circuitry as critical substrates for sensorim motor gating of the startle reflex.
Schizophrenia BulletinNeurobiological Studies of Sensory Gating in Schizophrenia
425 Citations1987Robert Freedman, Lawrence E. Adler +8 more
The neurobiological basis of this inability to filter has been examined using auditory evoked potentials, which are computerized averages of the brain's electrical response to sound, to find a mechanism by which noradrenergic hyperactivity in mania and other psychiatric illnesses might mimic some pathophysiological deficits in schizophrenia.
PsychophysiologyProbing picture perception: Activation and emotion
411 Citations1996Bruce N. Cuthbert, Margaret M. Bradleym +1 more
Both blink potentiation during unpleasant content and blink diminution during pleasant content were clearly strongest for picture contents high in arousal.
PsychophysiologyStartle Reflex Modification: Emotion or Attention?
406 Citations1990Margaret M. Bradley, Bruce N. Cuthbert +1 more
Analysis of reflex response and all ancillary measures supported the hypothesis that the primary determinant of startle modulation was the emotional valence of foreground content.
Journal of PsychopharmacologyThe neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications
394 Citations1992Neal R. Swerdlow, S. Barak Caine +2 more
Sensorimotor gating of the startle reflex appears to have a discrete and identifiable set of neural substrates that may be important for the understanding of neuropsychiatric disorders characterized by deficient suppression or 'gating' of sensory, cognitive or motor processes.
Journal of NeuroscienceA Primary Acoustic Startle Pathway: Obligatory Role of Cochlear Root Neurons and the Nucleus Reticularis Pontis Caudalis
380 Citations1996Young-Lim Lee, Dolores E. López +2 more
A primary acoustic startle pathway may involve three synapses onto cochlear root neurons, neurons in PnC, and spinal motoneurons, providing the first direct evidence for an involvement of CRNs in startle.
Distinguishing among Orienting, Defense, and Startle Reflexes
354 Citations2021Frances K. Graham
Behavioral NeuroscienceEmotion, novelty, and the startle reflex: Habituation in humans.
349 Citations1993Margaret M. Bradley, Peter Lang +1 more
Startle Modification: Implications for Neuroscience, Cognitive Science, and Clinical Science
345 Citations2008Michael E. Dawson, Anne M. Schell +1 more
This work aims to provide a systematic review of the literature on startle modification and its applications in clinical practice and investigates the relationships between individual differences, psychopathology, and startle reflex modification.
Journal of Abnormal PsychologyDo schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion?
341 Citations1996Ann M. Kring, John M. Neale
A disjunction among emotional response domains for schizophrenic patients is suggested; alternative explanations for the findings are considered as well as suggestions for future research.
Biological PsychiatryStartle gating deficits occur across prepulse intensities in schizophrenic patients
331 Citations1992Christian Grillon, Rezvan Ameli +3 more
The results suggest that schizophrenics have impaired central inhibitory mechanisms over a fairly broad range of background noise to prepulse ratios, and further studies are needed to clarify exactly which ratios are optimal in eliciting prepulse inhibition (PPI).
PsychophysiologyFear and the startle reflex: Blink modulation and autonomic response patterns in animal and mutilation fearful subjects
313 Citations1997Alfons O. Hamm, Bruce N. Cuthbert +2 more
Exposure to pictures of feared objects resulted in a consistent startle reflex potentiation and behavioral avoidance in both fear groups, suggesting that the probe startle response indexes the organism's basic motivational disposition and add new information to the assessment of fear.
PsychophysiologyPsychophysiological responses as indices of affective dimensions
310 Citations1995Charlotte vanOyen Witvliet, Scott R. Vrana
The startle reflex, facial electromyogram (EMG), and autonomic nervous system responses were examined during imagery varying in affective valence and arousal to establish a NA/PA framework that integrates previous research, dimensional theories of emotional behavior, and physiological assessment of pathological emotion.
American Journal of PsychiatryInformation-processing deficits and thought disorder in schizophrenia
310 Citations1994W. Perry, David Braff
Findings lend support to the hypothesis that information-processing failures are associated with cognitive fragmentation and thought disorder and allow us to hypothesize that impairments in part of the cortical-striatal-pallidal-thalamic circuit may lead to thought disorder, as well as prepulse inhibition deficits.
American Journal of PsychiatryImpaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder
308 Citations1993Kristin S. Cadenhead, Mark A. Geyer +1 more
It is suggested that subjects with schizotypal personality disorder perceive the prepulse stimuli but still demonstrate deficient sensorimotor gating of amplitude, which supports the importance of startle prepulse inhibition and startle habituation as biological markers for schizophrenia spectrum disorders.
PsychophysiologyPictures as prepulse: Attention and emotion in startle modification
258 Citations1993Margaret M. Bradley, Bruce N. Cuthbert +1 more
Effects of both attention and emotion can be simultaneously measured using this startle-probe paradigm, encouraging its use in both basic and clinical contexts.
Cambridge University Press eBooksAffect and the Startle Reflex
245 Citations1999Margaret M. Bradley, Bruce N. Cuthbert +1 more
Biological PsychiatryFear-potentiated startle in posttraumatic stress disorder
240 Citations1995Charles A. Morgan, Christian Grillon +3 more
The higher levels of startle in the PTSD group probably resulted from a greater conditioned emotional response in this group, triggered by anticipation of electric shocks that generalized to the unfamiliar experimental context in which testing occurred, which may be especially informative in distinguishing PTSD patients from other psychiatric diagnostic groups.
Biological PsychologyModification of the acoustic startle-reflex eyeblink: A tool for investigating early and late attentional processes
229 Citations1993Diane L. Filion, Michael E. Dawson +1 more
Results suggest that both short and long lead interval startle eyeblink modification measures may be useful tools for future investigations of the early and later stages of attentional processing.
Journal of Abnormal PsychologyAffective individual differences and startle reflex modulation.
226 Citations1991Edwin W. Cook, Larry W. Hawk +2 more
Startle responses were larger in all aversive affective states than during pleasant imagery, and followup testing indicated that other affective individual differences (depression and anger) may also be related to increased potentiation of startle in negative affect.
L. Erlbaum Associates eBooksEmotion : interdisciplinary perspectives
215 Citations1996Robert D. Kavanaugh, Betty Zimmerberg +1 more
Journal of Experimental Psychology Animal Behavior ProcessesTemporal specificity of fear conditioning: Effects of different conditioned stimulus--unconditioned stimulus intervals on the fear-potentiated startle effect.
191 Citations1989Michael Davis, Lee S. Schlesinger +1 more
The data indicate that even during simple fear conditioning, animals rapidly learn a temporal CS-US relationship, which has important implications for understanding the neural mechanisms of fear conditioning.
Journal of Abnormal PsychologyAttention and schizophrenia: Impaired modulation of the startle reflex.
189 Citations1993Michael E. Dawson, Erin A. Hazlett +3 more
Psychological ScienceA Motivational Analysis of Emotion: Reflex-Cortex Connections
181 Citations1992Peter J. Lang, Margaret M. Bradley +1 more
The neurobehavioral foundations of this conception are presented, and the implications of probe analysis are elucidated for theories of emotion organization, the assessment of mood, and practical applications in psychopathology and neurological disorder.
Schizophrenia BulletinThe Search for Symptoms Predictive of Schizophrenia
175 Citations1987Loren J. Chapman, Jean P. Chapman
Journal of Abnormal PsychologyEmotional learning, hedonic change, and the startle probe.
169 Citations1993Alfons O. Hamm, Mark K. Greenwald +2 more
A multiple-response analysis of aversive learning was conducted in human subjects: After training, the magnitude of the acoustic startle eyeblink reflex elicited in the context of the shocked picture increased dramatically and was significantly larger than for reflexes elicited during the nonshocked stimulus.
Journal of Abnormal PsychologyFear imagery and the startle-probe reflex.
162 Citations1990Scott R. Vrana, Peter J. Lang
Probe blink reflexes were larger and cardiac rate faster at fear sentence recall than at neutral sentence recall or relaxation, and this effect was greater for imagery than for nonsemantic recall tasks.
Biological PsychologyBlink reflex modification by selective attention: Evidence for the modulation of ‘automatic’ processing
159 Citations1985Bruno J. Anthony, Frances K. Graham
The results suggest that attention can influence 'automatic' sensory-perceptual analysis and suggest that modality-matching probes were presented over foregrounds judged a priori to be more 'interesting' than 'dull' foregrounds.
PsychophysiologyFearfulness and Startle Potentiation during Aversive Visual Stimuli
158 Citations1992Edwin W. Cook, Tammy L. Davis +3 more
The results support the hypothesis that affective modulation of startle is enhanced among high fear compared to low fear subjects and suggest that this individual difference effect generalizes across psychophysiological components of the startle reflex and diverse procedures for manipulating affect.
PsychophysiologyEmotional qualities of odors and their influence on the startle reflex in humans
155 Citations1994Wolfgang H. R. Miltner, M. MATJAK +3 more
Evaluating the emotional effects of positive and negative odorant stimuli found that H2S, a presumed negative foreground stimulus, significantly enhanced the startle-reflex amplitude relative to neutral air stimulation, whereas vanillin, a positive foreground stimuli, tended to reduce the reflex amplitude compared withneutral air stimulation.
Physiology & BehaviorRole of the inferior colliculus in the inhibition of acoustic startle in the rat
152 Citations1985Donald S. Leitner, Michelle E. Cohen
The proposition that the inferior colliculus is part of a neural circuit for startle amplitude reduction by auditory prestimuli is supported.
PsychophysiologyModulation of the acoustic startle response by film‐induced fear and sexual arousal
150 Citations1994DORINE M. JANSEN, Nico H. Frijda
Biological PsychiatrySensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia
149 Citations1994Francesca Bolino, Vittorio Di Michele +4 more
The data have confirmed the existence of an impairment of habituation and an abnormal facilitatory effect of R1 component of BR in schizophrenics compared to healthy controls and provides further evidence of specific defective mechanisms of information processing in schizophrenia.
Physiological PsychologyDiscordant effects of weak prestimulation on magnitude and latency of the reflex blink
141 Citations1977Frances K. Graham, G. M. Murray
The simultaneous occurrence of an inhibitory change in magnitude and a facilitatory change in latency, and the differential influence of lead stimulus duration, suggest that the magnitude and latency modifications involve different neural mechanisms with different time constants.
Cambridge University Press eBooksShort Lead Interval Startle Modification
137 Citations1999Terry D. Blumenthal
PsychophysiologyPrestimulation‐Induced Startle Modulation in Attention‐Deficit Hyperactivity Disorder and Nocturnal Enuresis
136 Citations1992Edward M. Ornitz, Gregory L. Hanna +1 more
The neurophysiologic dysfunction underlying the deficient startle inhibition in enuresis, but not ADHD, is discussed in terms of a possible dysfunction of mesopontine reticular mechanisms mediating preattentive processing of signals associated with spinal reflexes involved in urinary bladder control.
Biological Psychiatry“Normal” personality correlates of sensorimotor, cognitive, and visuospatial gating
135 Citations1995Neal R. Swerdlow, Diane L. Filion +2 more
Performance on all measures by "psychosis-prone" individuals suggested reduced sensorimotor gating and/or increased cognitive or visual interference in central inhibition, which was most impaired in individuals scoring highest on the MMPI Goldberg Index.
PsychophysiologyMeasuring the time course of anticipatory anxiety using the fear‐potentiated startle reflex
135 Citations1993Christian Grillon, Rezvan Ameli +3 more
The time course of the facilitation of the acoustic startle reflex induced by anticipation of electric shocks was measured and the magnitude of this fear-potentiated startle effect became progressively larger in the threat condition the longer the light was on and then abruptly decreased with the onset of the light signaling the no-threat condition.
Journal of Experimental Psychology Human Perception & PerformanceLead-stimulation effects on human cardiac orienting and blink reflexes.
128 Citations1975Frances K. Graham, Lois E. Putnam +1 more
Under conditions of temporal and stimulus uncertainty, the presentation of discrete stimuli at lead times that have no effect in rats produced blink facilitation as well as pronounced cardiac decelerations during the lead interval in man.
NeuroscienceLoss of the acoustic startle response following neurotoxic lesions of the caudal pontine reticular formation: Possible role of giant neurons
126 Citations1992Michael Koch, Kurt Lingenhöhl +1 more
It is concluded that the caudal pontine reticular formation is an important element of the startle pathway and that the giant reticulospinal neurons constitute an important part of the sensorimotor interface mediating this response.
Biological PsychiatryConcurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition
126 Citations1993Steven B. Schwarzkopf, J. Steven Lamberti +1 more
Results indicate that habituation of acoustic startle, but not PPI, is highly associated with P50 suppression in control subjects and an unexpected finding was a robust positive correlation between P50 amplitude and both measures of startle inhibition.
PsychophysiologyIs Elicitation of the Autonomic Orienting Response Associated With Allocation of Processing Resources?
125 Citations1989Michael E. Dawson, Diane L. Filion +1 more
Findings indicate that the relationship between resource allocation and autonomic orienting is a reliable but complex one in need of further research.
PsychophysiologyStartle and Emotion: Lateral Acoustic Probes and the Bilateral Blink
120 Citations1991Margaret M. Bradley, Brucse N. Cuthbert +1 more
Findings suggest that the startle probe indexes emotional processing that is lateralized in the central nervous system, and is therefore likely to be independent of attention or interest.
Cambridge University Press eBooksStartle Elicitation: Stimulus Parameters, Recording Techniques, and Quantification
116 Citations1999Wendy K. Berg, Marie T. Balaban
Behavioral NeuroscienceTemporal resolution of gaps in noise by the rat is lost with functional decortication.
115 Citations1991James R. Ison, Kevin N. O’Connor +2 more
The loss of gap sensitivity after KCl application indicates that gap processing, unlike pulses and offsets, depends on cortical mechanisms, as well as suggesting additional sensory processing with the longer lead time.
Journal of Personality DisordersSchizotypal Personality Disorder
115 Citations2012Erán Chemerinski, Joseph Triebwasser +2 more
Given the documented close relationship to other schizophrenic disorders, SPD will be included in the psychosis section of DSM-5 as a schizophrenia spectrum disorder as well as in the personality disorder section.
Journal of Experimental Psychology Human Perception & PerformanceEffects of attending selectively to the spatial position of reflex-eliciting and reflex-modulating stimuli.
114 Citations1987Steven A. Hackley, Frances K. Graham
Results appear to support a preset differential processing of stimuli in sensory pathways at low, possibly subcortical, levels and the consequent modification of obligatory, automatic processes.
Journal of Abnormal PsychologyAlcohol and human emotion: A multidimensional analysis incorporating startle-probe methodology.
108 Citations1995Werner G. K. Stritzke, Christopher J. Patrick +1 more
It is suggested that "stress-response dampening" by alcohol may involve a nonspecific attenuation of arousal reactions evident for positive as well as negative stimuli and that theories of motivation for drinking that are based on mood alteration may need refinement.
Child DevelopmentAffective Influences on Startle in Five-Month-Old Infants: Reactions to Facial Expressions of Emotion
107 Citations1995Marie T. Balaban
Results suggest that, by 5 months, infants react to affective information conveyed by unfamiliar human faces, and potential mechanisms mediating the influence of affective stimuli on reflex excitability are considered.
Physiological PsychologyEarly selective attention effects on cutaneous and acoustic blink reflexes
106 Citations1983Steven A. Hackley, Frances K. Graham
In two experiments, selective modulation of the human blink reflex was examined by direct ing subjects to judge duration of the startling or nonstartling member of an acoustic-cutaneous stimulus pair, and Hillyard and Naatanen suggested that a selective state was "already prevailing" at the moment of stimulus de livery.
PsychophysiologyMaturation of Startle Modulation
105 Citations1986Edward M. Ornitz, Donald Guthrie +3 more
It is suggested that brainstem mechanisms which mediate startle response modulation undergo development during early childhood and do not mature until about 8 years of age.
PsychophysiologyPsychophysiology at the Interface of Clinical Science, Cognitive Science, and Neuroscience
103 Citations1990Michael E. Dawson
Electrodermal abnormalities in schizophrenic patients have been found reliably across laboratories, and data reported here demonstrate that these abnormalities are at least partially dependent upon the clinical state of the patients.
PsychophysiologyStartle reflex modulation during exposure to pleasant and unpleasant odors
101 Citations1995Howard Ehrlichman, Sandra M. Brown +2 more
The eyeblink component of the startle response to acoustic probes was measured while subjects smelled pleasant odors, unpleasant Odors, or no odor, and the results may be compatible with the suggestion that the motivational state that modulates startle involves both valence and arousal.
PsychophysiologyModification of the Acoustic Startle Reflex by a Tactile Prepulse: The Effects of Stimulus Onset Asynchrony and Prepulse Intensity
95 Citations1987Terry D. Blumenthal, George A. Gescheider
The prepulse intensity and lead time effects shown demonstrate that the presentation of a brief, near-threshold tactile prepulse can either facilitate or inhibit an acoustically-elicited startle response, depending upon the temporal relationship between the two stimuli.
Journal of Abnormal PsychologyDiazepam blocks fear-potentiated startle in humans.
89 Citations1996Christopher J. Patrick, Bryan D Berthot +1 more
It is suggested that a common defensive state mediates startle reflex potentiation in animals and humans and that this index of fear can be used to assess the emotional effects of different drugs.
PsychophysiologyModulation of spinal reflexes: Arousal, pleasure, action
87 Citations1995Michel Bonnet, Margaret M. Bradley +2 more
Results showed that T reflexes were facilitated during processing of arousing stimuli-either pleasant or unpleasant relative to low-arousal neutral materials, consistent with hypothesis that motivational priming underlies affective reflex modulation.
PubMedGating and habituation deficits in the schizophrenia disorders.
86 Citations1995David Braff, Neal R. Swerdlow +1 more
Neurobiological manipulations along various axes of the cortico-striato-pallido-pontine (CSPP) can allow investigators to understand the neural basis of impaired gating and habituation in the schizophrenia.
Schizophrenia BulletinSensory Gating and Inhibitory Function in Late-life Schizophrenia
83 Citations1993Joan M. McDowd, Diane L. Filion +2 more
ScienceAttentional Factors in the Inhibition of a Reflex by a Visual Stimulus
76 Citations1980Elizabeth M. DelPezzo, Howard S. Hoffman
A brief stimulus presented to various regions of the visual field inhibited the eyeblink elicited by a subsequent tap to the skin between the eyebrows, and subjects were able to switch their attention toward or away from the target area without moving their eyes.
PsychophysiologyMaturation of Prestimulation‐Induced Startle Modulation in Girls
71 Citations1991Edward M. Ornitz, Donald Guthrie +2 more
It is suggested that brainstem mechanisms that mediate startle response modulation undergo development during early childhood and do not mature until about 8 years of age in both male and female subjects.
PsychophysiologyReflex Modification in Psychosis‐Prone Young Adults
70 Citations1992Robert F. Simons, Barbara Diane Giardina
The results suggest that subjects with perceptual aberrations may share with schizophrenics and other schizophrenia-spectrum subjects an underdeveloped mechanism which in normal subjects is presumed to operate during preattentive processing and functions to protect sensory information from the interfering effects of subsequent stimuli.
Electroencephalography and Clinical NeurophysiologyPreconditioning and excitability of the human orbicularis oculi reflex as a function of state
70 Citations1980Louis D. Silverstein, Frances K. Graham +1 more
Reflex excitability and unstimulated activity of orbicularis oculi were found to vary as a function of state but the effects of weak conditioning stimuli, preceding reflex stimulation by 30--210 msec, were independent of state.
PsychophysiologySelective Attention Effects on the Reflex Blink
69 Citations1981Louis D. Silverstein, Frances K. Graham +1 more
The present studies showed that when warning stimuli directed attention instead to weak stimuli presented simultaneously with reflex-eliciting (acoustic) stimuli, cardiac deceleration was still present but reflex magnitude was unchanged or inhibited, however, latency to reflex onset remained facilitated, i.e., latency and magnitude changes were discordant.
PsychophysiologyProbing the orienting response with startle modification and secondary reaction time
68 Citations1994Diane L. Filion, Michael E. Dawson +1 more
The results support a relationship between elicitation of the skin conductance orienting response and attentional processes and suggest that the secondary reaction time and blink modification techniques may provide unique information regarding this relationship.
PsychophysiologyThe Relationship Between Skin Conductance Orienting the Allocation of Processing Resources
67 Citations1991Diane L. Filion, Michael E. Dawson +2 more
The results support the hypothesis that the dissociation effect is due to a switch of attention initiated because of the physical similarity of the task-relevant and task-irrelevant stimuli, and suggest that there is a fundamentally positive relationship between skin conductance orienting and resource allocation under selective attention conditions.
European Archives of Psychiatry and Clinical NeuroscienceAffective modulation of the startle reflex in schizophrenic patients
67 Citations1995R. Schlenker, Rudolf Cohen +1 more
Diminished affective expression rated on the basis of a clinical interview is not associated with a general attenuation of the blink reflex or of its modulation by exposure to emotional slides, and there is no indication of an impairment in the perception of affective stimuli nor of reduced appreciation of pleasant stimuli.
The Journal of the Acoustical Society of AmericaTemporal Parameters in Startle Facilitation by Steady Background Signals
66 Citations1969Howard S. Hoffman, Barry L. Wible
Results indicated that 100 msec of exposure to abackground signal is adequate for full development of the facilitation effect, and that the effect exhibits a significant decline by no more than 8 msec after the termination of a background signal.
PsychophysiologyThe Effect of an Acoustic Warning Stimulus Upon the Electrically Elicited Blink Reflex in Humans
65 Citations1991A.J.W. Boelhouwer, R.J.M.A. Teurlings +1 more
It was concluded that the mutual effects of stimuli of different modalities can be interpreted only if the moment of arrival at the motor nucleus is taken into consideration.
Cambridge University Press eBooksNeurophysiology and Neuropharmacology of Short Lead Interval Startle Modification
65 Citations1999Neal R. Swerdlow, Mark A. Geyer
PsychophysiologyThe varying time courses of attentional and affective modulation of the startle eyeblink reflex
64 Citations1996Eric J. Vanman, Andreas H. Boehmelt +2 more
The results suggest that the time courses of emotional and attentional modulation of startle are variable and can occur at both early and late startle probe positions, depending on task requirements.
PsychophysiologyLateralized startle probes in the study of emotion
63 Citations1996Margaret M. Bradley, Bruce N. Cuthbert +1 more
Modulatory differences in reflex magnitude between pleasant and unpleasant stimuli were consistently large and reliable for reflexes elicited by left ear probes but weak and unreliable for Reflexes eliciting by right ear probes.
PsychophysiologyTracking early and late stages of information processing: Contributions of startle eyeblink reflex modification
62 Citations1996Penny Jennings, Anne M. Schell +2 more
College students were presented with tones of 5 and 7 s duration of either high or low pitch, followed by startle-eliciting stimuli at lead intervals of 120, 2,000, 4,500, or 6,000 ms, indicating that early and late controlled processing was occurring.
ScienceEvidence for Sensory-Selective Set in Young Infants
62 Citations1983Bruno J. Anthony, Frances K. Graham
This present study suggests that filtering by modality exists at levels low enough to modulate the brainstem blink reflex and that it is evident as early as the 16th week of life.
PsychophysiologyAttentional modulation of startle in psychosis‐prone college students
61 Citations1995Anne M. Schell, Michael E. Dawson +2 more
The results for the per-mags are strikingly similar to those observed in schizophrenic patients and suggest that these deficits index a trait-linked vulnerability to disorders in the schizophrenic spectrum.
Personality and Individual DifferencesPsychosis proneness in a non-clinical sample II: A multi-experimental study of “Attentional malfunctioning”
61 Citations1994Ottmar V. Lipp, David A.T. Siddle +1 more
PsychophysiologyCardiac Orienting and Startle Blink Modification in Novel and Signal Situations
59 Citations1981Gunilla Bohlin, Frances K. Graham +2 more
In both experiments, blink latency but not magnitude was facilitated by the irrelevant tactile stimuli, thus supporting previous suggestions of a dissociation between these measures of reflex strength.
Great Expectations: Anticipatory Responses Of The Heart And Brain
59 Citations1990Lois E. Putnam
PsychophysiologyLead stimulation effects on reflex blink, exogenous brain potentials, and loudness judgments
58 Citations1993William M. Perlstein, EVELYN R. FIORITO +2 more
Blinks and exogenous potentials peaking after 50 ms were smaller for the second tone of pairs than for equal-intensity single tones, and the loudness of 75-dB first and second tones was unaffected or increased.
PsychophysiologyCardiac Deceleration and Reflex Blink Facilitation
58 Citations1977Gunilla Bohlin, Frances K. Graham
This hypothesis that facilitation was not due to orienting per se but to rebound when orienting was terminated by the blink-eliciting stimulus was tested by manipulation of attentional requirements and was disconfirmed.
PsychophysiologyEngaging Visual Stimuli and Reflex Blink Modification
55 Citations1985Robert F. Simons, Michael F. Zelson
The successful use of EOG techniques to record the eyeblink component of the startle reflex and capture its sensitivity to the attentional manipulation suggests that the probe startle paradigm may be readily put to use in a wide variety of psychophysiological laboratories.
Cambridge University Press eBooksNeurophysiology and Neuropharmacology of Startle and Its Affective Modification
52 Citations1999Michael Davis, David Walker +1 more
Cambridge University Press eBooksPsychopathic Traits and Intoxicated States: Affective Concomitants and Conceptual Links
47 Citations1999Christopher J. Patrick, Alan R. Lang
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