Epidemiology of Dementia and Alzheimer's Disease
American Journal of Geriatric PsychiatryPublished 1 March 1998
Hugh C. Hendrie
Citations412
SJR quartileQ1
SJR score1.38
SNIP1.21
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TL;DR
Only age and family history of dementia are consistently associated with AD in all studies, but putative, protective agents such as estrogen, nonsteroidal anti-inflammatory agents (NSAIDs), and vitamin E are now undergoing clinical trials.
Abstract
The prevalence of dementia in subjects 65 years and older in North America is approximately 6%-10%, with Alzheimer's disease (AD) accounting for two-thirds of these cases. If milder cases are included, the prevalence rates double. Both causative and associative genes for AD have now been identified. The search for nongenetic risk factors has been less conclusive. Only age and family history of dementia are consistently associated with AD in all studies, but putative, protective agents such as estrogen, nonsteroidal anti-inflammatory agents (NSAIDs), and vitamin E are now undergoing clinical trials.
Keywords
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NeurologyAlzheimer's disease
133 Citations1996Ranjan Duara, Warren Barker +6 more
Patients with predominantly late-onset Alzheimer's disease who belonged to several ethnic groups found a reduced age of onset in women, but not men, who were both FH+ and epsilon 4+ and were more likely to inherit the disease from their mothers than their fathers.
Biological PsychiatryAssociation between dementia and elevated TSH: A community-based study
133 Citations1996Mary Ganguli, Lynn A. Burmeister +3 more
This is the first community-based study to report an association between TSH elevation and dementia, and is consistent with recent evidence that subclinical hypothyroidism is associated with cognitive impairment, and that thyroidal state may influence cerebral metabolism.
NeurologyElevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure
133 Citations1996Raymond A. Sobel, M. Dunn +3 more
A case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer's disease with patients from the Alzheimer Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA, consistent with previous findings regarding the hypothesis that electromagnetic field exposure is etiologically associated with the occurrence of AD.
NeurologyEpidemiology, education, and the ecology of Alzheimer's disease
129 Citations1993Robert P. Friedland
Education was found to be protective against the development of AD in prevalence studies performed in Israell8; the Netherland; Shanghai7JoJ7; Sweden; Finland; Italy; and France, and the evidence supports the protective effect of education.
American Journal of EpidemiologyRelation of Smoking and Alcohol Consumption to Incident Alzheimer's Disease
127 Citations1992Liesi E. Hebert, Paul A. Scherr +5 more
It is suggested that recent mild-to-moderate consumption of alcohol is not substantially related to incidence of Alzheimer's disease and that smoking does not increase risk of the disease.
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