Epidermal growth factor receptors in human breast cancer
Breast Cancer Research and TreatmentPublished 1 September 1984
Rolando Pérez, María Eva Vallejo Pascual, Amparo Macías, Agustín Lage
Citations187
SJR quartileQ1
SJR score1.35
SNIP1.00
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TL;DR
High EGF receptor values were associated with a low content of estradiol receptor, and these studies are related to the definition of new biochemical markers in human breast cancer.
Abstract
The capacity for specific binding of 125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demonstrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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