Genetic susceptibility testing versus family history–based risk assessment: Impact on perceived risk of Alzheimer disease
Genetics in MedicinePublished 1 January 2005Open access
Susan LaRusse, J. Scott Roberts, Theresa M. Marteau, Heather Katzen, Erin Linnenbringer, Melissa Barber
Citations67
SJR quartileQ1
SJR score2.68
SNIP2.38
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TL;DR
It is suggested that risk estimates incorporating negative genetic test results affect perceptions of disease susceptibility more strongly than identical estimates based on family history alone.
Abstract
These data suggest that risk estimates incorporating negative genetic test results affect perceptions of disease susceptibility more strongly than identical estimates based on family history alone.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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Facts and Fears: Understanding Perceived Risk
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JAMAStatement on Use of Apolipoprotein E Testing for Alzheimer Disease
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243 Citations1996NormanR. Relkin
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American Journal of Medical GeneticsReluctance to undergo predictive testing: The case of Huntington Disease
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Health PsychologyIncorporating biomarkers of exposure and genetic susceptibility into smoking cessation treatment: Effects on smoking-related cognitions, emotions, and behavior change.
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The GerontologistAnticipating response to predictive genetic testing for Alzheimer'sdisease: a survey of first-degree relatives
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Neurobiology of Aging332 Early detection of Alzheimer's disease: Methods, markers and misgivings
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