Relationship between Adherence and the Development of Resistance in Antiretroviral‐Naive, HIV‐1–Infected Patients Receiving Lopinavir/Ritonavir or Nelfinavir
The Journal of Infectious DiseasesPublished 20 May 2005Open access
Martin King, Scott C. Brun, Dale J. Kempf
Citations90
SJR quartileQ1
SJR score2.04
SNIP1.23
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Bell-shaped relationships between adherence and resistance were observed, and the risk of detectable HIV-1 RNA loads or of PI or lamivudine resistance was significantly higher in nelfinavir- treated patients than in lopinavir/ritonavir-treated patients.
Abstract
Bell-shaped relationships between adherence and resistance were observed. Irrespective of adherence level, the risk of detectable HIV-1 RNA loads or of PI or lamivudine resistance was significantly higher in nelfinavir-treated patients than in lopinavir/ritonavir-treated patients.
Keywords
Immunology and MicrobiologyMedicine
Annals of Internal MedicineAdherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
3,328 Citations2000David L. Paterson, Susan Swindells +6 more
Given the critical importance of adherence to therapy to patient outcome, secondary prevention of HIV infection, and willingness of providers to prescribe therapy, this prospectively investigated the association between protease inhibitor adherence and patient outcome and factors related to adherence.
Journal of Quality TechnologyLocal Polynomial Modelling and its Applications
1,202 Citations1997Karen A. F. Copeland
AIDSNon-adherence to highly active antiretroviral therapy predicts progression to AIDS
956 Citations2001David R. Bangsberg, Sharon Perry +5 more
The introduction of highly active antiretroviral therapy (HAART) has produced a dramatic reduction in mortality among HIV-infected individuals, and the level of adherence to HAART is closely associated with suppression of the HIV viral load in plasma.
Annals of Internal MedicineA Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
762 Citations2001Honghu Liu, Carol E. Golin +9 more
Using HIV viral load as a clinical criterion, methods of measuring adherence to antiretroviral therapy among HIV-infected patients were compared, a composite adherence score (CAS) was developed, and the associations between each adherence measure and viral load were analyzed.
New England Journal of MedicineLopinavir–Ritonavir versus Nelfinavir for the Initial Treatment of HIV Infection
647 Citations2002Sharon Walmsley, Barry Bernstein +10 more
For the initial treatment of HIV-infected adults, a combination regimen that includes lopinavir-ritonavir is well tolerated and has antiviral activity superior to that of a nelfinavIR-containing regimen.
Clinical Infectious DiseasesAntiretroviral Drug Resistance Testing in Adults Infected with Human Immunodeficiency Virus Type 1: 2003 Recommendations of an International AIDS Society–USA Panel
516 Citations2003Martin Hirsch, Françoise Brun‐Vézinet +11 more
The International AIDS Society-USA convened a panel of physicians and scientists with expertise in antiretroviral drug management, HIV-1 drug resistance, and patient care to provide updated recommendations for HIV- 1 resistance testing.
Annals of Internal MedicineCorrection: Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
506 Citations2002
JAMAPublic Health Implications of Antiretroviral Therapy and HIV Drug Resistance
502 Citations1998Mark A. Wainberg
Unless this topic is appropriately addressed, the likelihood is that drug-resistant variants of HIV, if able to successfully replicate, will sustain the epidemic and limit the effectiveness of antiviral therapy.
Clinical Infectious DiseasesAssociation between Adherence to Antiretroviral Therapy and Human Immunodeficiency Virus Drug Resistance
483 Citations2003A. K. Sethi, David D. Celentano +3 more
A cumulative adherence of 70%-89%, a CD4 cell nadir of <200 cells/microL, and the missing of a scheduled clinic visit in the past month were independently associated with an increased hazard of viral rebound with clinically significant resistance.
New England Journal of MedicineIntrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-Based Antiretroviral Therapy
442 Citations2004Gonzague Jourdain, Nicole Ngo‐Giang‐Huong +8 more
Women who received intrapartum nevirapine were less likely to have virologic suppression after six months of postpartum treatment with a ne virapine-containing regimen, and the need for strategies to maximize the benefits of both antiretroviral prophylaxis against mother-to-child transmission of HIV and antireTroviral therapy for mothers is suggested.
The Journal of Infectious DiseasesPredictors of HIV Drug‐Resistance Mutations in a Large Antiretroviral‐Naive Cohort Initiating Triple Antiretroviral Therapy
434 Citations2005P. Richard Harrigan, Robert S. Hogg +9 more
High baseline pVLs and substantial but imperfect levels of adherence were major predictors of antiretroviral resistance.
AIDSIntermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up
425 Citations2002Robert S. Hogg, Katherine Heath +5 more
It is demonstrated that even after adjusting for other prognostic factors intermittent use of antiretroviral therapy was associated with increased mortality, and that those participants who used antireTroviral drugs intermittently were more likely to die.
Annals of Internal MedicineEffect of Medication Adherence on Survival of HIV-Infected Adults Who Start Highly Active Antiretroviral Therapy When the CD4+ Cell Count Is 0.200 to 0.350 × 10<sup>9</sup> cells/L
363 Citations2003Evan Wood, Robert S. Hogg +4 more
The effect of baseline CD4+ cell count and adherence on survival rates after the initiation of HAART was evaluated and it was suggested that delaying HAART after the CD4- cell count declines below 0.350 109 cells/L may be unsafe.
AIDSHigh levels of adherence do not prevent accumulation of HIV drug resistance mutations
256 Citations2003David R. Bangsberg, Edwin D. Charlebois +9 more
Increasing rates of viral suppression at high levels of adherence is balanced by increasing rates of drug resistance among viremic patients, which will not prevent population levels ofdrug resistance.
The Journal of Infectious DiseasesIncidence of Resistance in a Double‐Blind Study Comparing Lopinavir/Ritonavir Plus Stavudine and Lamivudine to Nelfinavir plus Stavudine and Lamivudine
221 Citations2004Dale J. Kempf, Martin King +8 more
Differences suggest substantially different genetic and pharmacological barriers to resistance for these 2 protease inhibitors and may have implications for strategies for initiating antiretroviral therapy.
PubMedAttaining higher goals in HIV treatment: the central importance of adherence.
206 Citations1999Gerald Friedland, Aurelia A. Williams
The Journal of Infectious DiseasesOnce‐Daily versus Twice‐Daily Lopinavir/Ritonavir in Antiretroviral‐Naive HIV‐Positive Patients: A 48‐Week Randomized Clinical Trial
123 Citations2004Joseph J. Eron, Judith Feinberg +12 more
Over the course of 48 weeks, median predose concentrations of lopinavir exceeded the protein-binding corrected concentration required to inhibit replication of wild-type HIV by 50% in vitro by 40- and 84-fold in the once- and twice-daily groups, respectively.
AIDSLong-term safety and durable antiretroviral activity of lopinavir/ritonavir in treatment-naive patients
111 Citations2004Charles B. Hicks, Martin King +8 more
LPV/r-based therapy provides durable antiretroviral response and is generally well tolerated through 204 weeks of therapy, and no isolate demonstrated primary or active site mutations in protease.
International Journal of Behavioral MedicineFailure to maintain adherence to haart in a cohort of French HIV-positive injecting drug users
103 Citations2003Patrizia Carrieri, Margaret A. Chesney +5 more
Logistic regression showed that lack of a stable relationship, active drug injection, and depression were independently associated with adherence failure and patients’ counseling for facilitating maintenance of adherence to HAART over time should focus on prevention of drug use, provision of social support and consider the potential impact of difficulties with treatment on psychological well-being.
JAIDS Journal of Acquired Immune Deficiency SyndromesVirologic Rebound on HAART in the Context of Low Treatment Adherence Is Associated With a Low Prevalence of Antiretroviral Drug Resistance
88 Citations2002John Walsh, Anton Pozniak +3 more
The contributions of viral drug resistance, drug pharmacokinetics, and treatment adherence to failure of protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) have been explored in isolation and the interactions between these factors were examined.
AIDSDrug resistance in patients experiencing early virological failure under a triple combination including indinavir
70 Citations2001Óscar Gallego, Carmen de Mendoza +12 more
Resistance to nucleoside analogues was more frequent than resistance to indinavir; treatment intensification in those patients without resistance, or a selective substitution of nucleosides in those with resistance limited to these compounds, might be justified.
The Journal of Infectious DiseasesModeling the HIV Protease Inhibitor Adherence–Resistance Curve by Use of Empirically Derived Estimates
69 Citations2004David R. Bangsberg, Travis C. Porco +6 more
This work statistically modeled the relationship between adherence and development of drug resistance, using empirically defined relationships of the rate of viral suppression and drug-resistance-mutation accumulation derived from patients receiving protease-inhibitor-based therapy.
AIDSGW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients
67 Citations2004S. MacManus, Phillip J. Yates +4 more
The absence of resistance to 908 or cross-resistance to other PIs, and reduced NRTI resistance, following a 908/r q.i.d. regimen supports the use of this boosted PI early in therapy.
The Journal of Infectious DiseasesBaseline HIV‐1 RNA Level and CD4 Cell Count Predict Time to Loss of Virologic Response to Nelfinavir, but Not Lopinavir/Ritonavir, in Antiretroviral Therapy–Naive Patients
32 Citations2004Martin King, Barry Bernstein +8 more
For nelfinavir-treated patients, but not for lopinavir/ritonavir- treated patients, higher baseline HIV-1 RNA levels and lower baseline CD4 cell counts were associated with a higher risk of loss of virologic response.
PubMedManaging issues related to antiretroviral therapy.
28 Citations2003Emil Lesho, Daniela Gey
Antiretroviral regimens are complicated and difficult for patients to follow, and they can have serious side effects, such as osteonecrosis and bone demineralization.
Survey of AnesthesiologyIntrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-Based Antiretroviral Therapy
12 Citations2005Brett G. Gutsche
JAIDS Journal of Acquired Immune Deficiency SyndromesVirologic Rebound on HAART in the Context of Low Treatment Adherence Is Associated With a Low Prevalence of Antiretroviral Drug Resistance
8 Citations2002John Walsh, Anton Pozniak +3 more