Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine
Journal of HypertensionPublished 1 March 2004
Germaine Escames, Huda Khaldy, Josefa Le n, Luis Gonz lez, Dar o Acu a-Castroviejo
Citations41
SJR quartileQ1
SJR score1.10
SNIP1.63
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TL;DR
Besides reducing blood pressure, lacidipine treatment significantly decreased plasma LPO and macrophage iNOS activity, without changes in NO, which is suggested to enhance the beneficial effects of each drug in essential hypertension.
Abstract
Besides reducing blood pressure, lacidipine treatment significantly decreased plasma LPO and macrophage iNOS activity, without changes in NO. Melatonin significantly increases in hypertensive patients, returning to control after lacidipine. Thus, lacidipine reduced blood pressure and free radicals, avoiding the oxidative damage to endothelium. It is suggested that administration of lacidipine plus melatonin may enhance the beneficial effects of each drug in essential hypertension.
Keywords
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