Cognitive functions of cortical ACh: lessons from studies on trans-synaptic modulation of activated efflux
Trends in NeurosciencesPublished 1 June 1994
Martin Sarter, John P. Bruno
Citations92
SJR quartileQ1
SJR score4.73
SNIP3.68
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TL;DR
Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortex ACh and may offer some potential for the treatment of cognitive dysfunctions associated with impaired cortical cholinergic transmission.
Abstract
Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortical ACh. Bilateral modulation of basal forebrain GABAergic transmission by benzodiazepine-receptor agonists and inverse agonists decreases and increases, respectively, activated cortical ACh efflux. The determination of behavioral functions which are mediated via activated cortical ACh efflux, and therefore subject to the effects of basal forebrain GABA-cholinergic manipulations, should promote analyses of the functions of cortical ACh. Trans-synaptic approaches to enhance activated cortical ACh efflux offer some potential for the treatment of cognitive dysfunctions associated with impaired cortical cholinergic transmission.
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