Local infusion of an α-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys
Biological PsychiatryPublished 1 November 1999
Zheng-Mei Mao, Amy F.T. Arnsten, Baoming Li
Citations155
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
Stimulation of prefrontal cortical alpha-1 adrenoceptor impairs SWM function in monkeys, consistent with the parallel study in rats, whereas stimulation of alpha-2 adrenoceptors improves SWM, indicating thatalpha-1 andalpha-2 Adrenoceptor may have opposing roles in the PFC.
Abstract
Stimulation of prefrontal cortical alpha-1 adrenoceptors impairs SWM function in monkeys, consistent with the parallel study in rats, whereas stimulation of alpha-2 adrenoceptors improves SWM, indicating that alpha-1 and alpha-2 adrenoceptors may have opposing roles in the PFC.
Keywords
MedicineNeuroscience
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