Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders 1 1This study was registered with ClinicalTrials.gov (trial registry no. NCT00006157).
GastroenterologyPublished 1 July 2003
Douglas A. Drossman, Brenda B. Toner, William E. Whitehead, Nicholas E. Diamant, Chris Dalton, Susan Duncan
Citations611
SJR quartileQ1
SJR score7.20
SNIP5.04
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
For female patients with moderate to severe FBD, CBT is effective and DES may be effective when taken adequately, and certain clinical subgroups are more or less amenable to these treatments.
Abstract
For female patients with moderate to severe FBD, CBT is effective and DES may be effective when taken adequately. Certain clinical subgroups are more or less amenable to these treatments.
Keywords
MedicineHealth Professions
PainThe McGill Pain Questionnaire: Major properties and scoring methods
6,816 Citations1975Ronald Melzack
The data indicate that the McGill Pain Questionnaire provides quantitative information that can be treated statistically, and is sufficiently sensitive to detect differences among different methods to relieve pain.
GutFunctional bowel disorders and functional abdominal pain
2,393 Citations1999Wade Thompson, George F. Longstreth +4 more
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.
Designing Clinical Research
1,764 Citations2006Stephen B. Hulley
BASIC INGREDIENTS Getting Started: The Anatomy and Physiology of Clinical Research Stephen B. Hulley and Steven R. Cummings Getting Ready to Estimate Sample Size: Hypotheses and Underlying Principles Warren S. Browner, Thomas B. Newman, and Stephen R.Hulley Estimating Sample Size and Power: Applications and Examples.
Journal of Behavior Therapy and Experimental PsychiatryCredibility of analogue therapy rationales
1,568 Citations1972Thomas D. Borkovec, Sidney D. Nau
GastroenterologyThe burden of selected digestive diseases in the United States
1,517 Citations2002Robert S. Sandler, James E. Everhart +8 more
The most prevalent diseases were non-food-borne gastroenteritis, food-borne illness, gastroesophageal reflux disease, and irritable bowel syndrome, followed by gallbladder disease, which had the highest annual direct costs in the United States.
GastroenterologyAGA technical review on irritable bowel syndrome
1,406 Citations2002Douglas A. Drossman, Michael Camilleri +2 more
Psychosocial factors, although not part of IBS per se, have an important role in modulating the illness experience and its clinical outcome.
BiometricsProcedures for Comparing Samples with Multiple Endpoints
1,170 Citations1984Peter C. O’Brien
Five procedures are considered for the comparison of two or more multivariate samples, including a newly proposed nonparametric rank-sum test and a generalized least squares test, which may be useful with normally distributed data in moderate or large samples.
Annals of Internal MedicineSexual and Physical Abuse in Women with Functional or Organic Gastrointestinal Disorders
901 Citations1990Douglas A. Drossman, Jane Leserman +5 more
It is found that a history of sexual and physical abuse is a frequent, yet hidden, experience in women seen in referral-based gastroenterology practice and is particularly common in those with functional gastrointestinal disorders.
GastroenterologyPsychosocial Aspects of the Functional Gastrointestinal Disorders
780 Citations2006Rona L. Levy, Kevin W. Olden +5 more
There is now increasing evidence that a number of psychological treatments and antidepressants are helpful in reducing symptoms and other consequences of the FGIDs in children and adults.
Digestive Diseases and SciencesQuality of Life in Persons with Irritable Bowel Syndrome (Development and Validation of a New Measure)
729 Citations1998Donald L. Patrick, Douglas A. Drossman +3 more
This quality-of-life measure specific to irritable bowel syndrome meets established psychometric criteria for reliability and validity; testing of its responsiveness is warranted.
PainAntidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies
564 Citations1992Patrick Onghena, Boudewijn Van Houdenhove
Real analgesic qualities of antidepressive agents seemed to offer the most plausible and economical explanation for the effect, but the predominant importance of serotonin reuptake blocking was not confirmed.
GastroenterologyDesign of Treatment Trials for Functional Gastrointestinal Disorders
548 Citations2016E. Jan Irvine, Jan Tack +6 more
Journal of Gastroenterology and HepatologyStress and the gastrointestinal tract
483 Citations2005Vikram Bhatia, Rakesh Tandon
The association between stress and various gastrointestinal diseases, including functional bowel disorders, inflammatory bowel disease, peptic ulcer disease and gastroesophageal reflux disease, is being actively investigated.
The American Journal of MedicineTreatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
471 Citations2000Jeffrey L. Jackson, Patrick G. O’Malley +4 more
Treatment of functional gastrointestinal disorders with antidepressants appears to be effective, and whether this improvement is independent of an effect of treatment on depression needs further evaluation.
GastroenterologyA controlled trial of psychological treatment for the irritable bowel syndrome
467 Citations1991Elspeth Guthrie, Francis Creed +2 more
It is demonstrated that psychological treatment is feasible and effective in two thirds of those patients with irritable bowel syndrome who do not respond to standard medical treatment.
Annals of Internal MedicineUsing Numerical Results from Systematic Reviews in Clinical Practice
461 Citations1997Henry J McQuay, R. Andrew Moore
This paper provides guidance on how to interpret the numerical and statistical results of systematic reviews, translate these results into more understandable terms, and apply them directly to individual patients.
JAMAManagement of Chronic Tension-Type Headache With Tricyclic Antidepressant Medication, Stress Management Therapy, and Their Combination
452 Citations2001Kenneth A. Holroyd, Francis O’Donnell +4 more
The results indicate that antidepressant medication and stress management therapy are each modestly effective in treating chronic tension-type headaches.
The American Journal of GastroenterologyFurther validation of the IBS-QOL: a disease-specific quality-of-life questionnaire
394 Citations2000Douglas A. Drossman, Donald L. Patrick +6 more
The IBS-QOL is responsive to treatment in a referral-based clinical population of patients with functional bowel disorders and significantly differentiated Responders from Nonresponders for most of the variables tested.
GutHypnotherapy in severe irritable bowel syndrome: further experience.
255 Citations1987Peter J. Whorwell, Alison Prior +1 more
The successful effect of hypnotherapy in a larger series of patients with irritable bowel syndrome is confirmed and some subgroup variations are defined.
GastroenterologyAmerican Gastroenterological Association medical position statement on anorectal testing techniques
245 Citations1999Jeffrey L. Barnett, William L. Hasler +1 more
Statistics in MedicineMultiple testing in clinical trials
240 Citations1991Péter Bauer
The main emphasis is on the concept of the multiple level of significance (controlling the experiment, or family error in the strong sense) which can be achieved by applying the principle of closed tests.
GastroenterologyHealth status by gastrointestinal diagnosis and abuse history
237 Citations1996DA Drossman, Zhongrui Li +3 more
The type of diagnosis and abuse history independently contributed to the health status of this population of patients and medical symptoms alone may not be sufficient to understand patients' health status.
Biological PsychiatryDoes psychosocial functioning improve independent of depressive symptoms? a comparison of nefazodone, psychotherapy, and their combination
229 Citations2002Robert M. A. Hirschfeld, David L. Dünner +15 more
This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients to find combined treatment had greater effect than either monotherapy.
Psychosomatic MedicineEffects of Coping on Health Outcome Among Women With Gastrointestinal Disorders
213 Citations2000Douglas A. Drossman, Jane Leserman +4 more
American Journal of Geriatric PsychiatryComparison of Desipramine and Cognitive/Behavioral Therapy in the Treatment of Elderly Outpatients With Mild-to-Moderate Depression
211 Citations2001L. W. Thompson, David W. Coon +3 more
The results indicate that psychotherapy can be an effective treatment for older adult outpatients with moderate levels of depression, particularly when desipramine was at or above recommended stable dosage levels.
Digestive Diseases and SciencesEffects of desipramine on irritable bowel syndrome compared with atropine and placebo
182 Citations1987David S. Greenbaum, James E. Mayle +9 more
The American Journal of MedicineDo psychosocial factors define symptom severity and patient status in irritable bowel syndrome?
164 Citations1999Douglas A. Drossman
It is important to consider psychosocial factors as predictive of symptom severity and clinical outcome, and this should be considered in clinical care and the design of clinical trials.
Digestive Diseases and SciencesFunctional bowel disorders
161 Citations1995Douglas A. Drossman, Zhiming Li +11 more
The FBDSI can be used to select patients for research protocols and/or follow their clinical outcome or response to treatments over time to develop a functional bowel disorder severity index for research and clinical care.
The American Journal of GastroenterologyWhat determines severity among patients with painful functional bowel disorders?
155 Citations2000Douglas A. Drossman, William E. Whitehead +5 more
It is concluded that patient illness behaviors are best correlated with severity in FBD, and training to help medical physicians identify and respond to psychosocial and behavioral features of these conditions is likely to improve patient satisfaction with their care and the clinical outcome.
Psychosomatic MedicineDo Antidepressants Have an Analgesic Effect in Psychogenic Pain and Somatoform Pain Disorder? A Meta-Analysis
132 Citations1998David A. Fishbain, Robert B. Cutler +2 more
The results indicate that, in patients diagnosed with psychogenic pain or somatoform pain disorder, antidepressant treatment resulted in a reduction in pain that was significantly greater than that of placebo.
Statistics in MedicineSome large‐sample distribution‐free estimators and tests for multivariate partially incomplete data from two populations
100 Citations1992John M. Lachin
Alternative K and 1 d.f. distribution-free procedures which allow for randomly missing observations are described, and an analysis of repeated cholesterol measurements in two groups of patients, stratified by sex is illustrated.
International Journal of Group PsychotherapyCognitive-Behavioral Group Therapy for Patients with Irritable Bowel Syndrome
92 Citations1998Brenda B. Toner, Zindel V. Segal +5 more
This article is divided into two parts, the first of which focuses on a general overview of irritable bowel syndrome and provides a rationale for the use of cognitive-behavioral therapy (CBT) for IBS based on both theoretical and research perspectives.
Stress and the gastrointestinal tract. V. Stress and irritable bowel syndrome
92 Citations2001Emeran A. Mayer, Bruce D. Naliboff +2 more
Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations of irritable bowel syndrome patients, and animal models have recently been proposed that mimic key features of the human syndrome.
Psychosomatic MedicineThe Development of a Cognitive Scale for Functional Bowel Disorders
91 Citations1998Brenda B. Toner, Noreen Stuckless +4 more
The Cognitive Scale for Functional Bowel Disorders is a valid and reliable scale that can be used as an outcome measure in evaluating the efficacy of different forms of psychotherapeutic intervention for FBD, and can also serve as a helpful assessment tool for health professionals working with patients diagnosed with FBD.
Journal of Psychiatry and NeuroscienceEfficacy of combined, sequential and crossover psychotherapy and pharmacotherapy in improving outcomes in depression
72 Citations2002Zindel V. Segal, Pierre Vincent +1 more
Cognitive therapy may play a role in improving remission rates and decreasing relapse and recurrence rates and there is a consistent suggestion of superior prophylaxis for patients receiving some type of sequenced or crossover treatment in which the delivery of antidepressant medication and structured antidepressant psychotherapy is combined.
PubMedPsychosocial sound bites: exercises in the patient-doctor relationship.
44 Citations1997D A Drossman
For the physician to develop a communication style that supports an effective patient-physician interaction, to improve the therapeutic outcome, included in this article are eight challenging comments made by patients in the course of a clinical visit.
Guilford Press eBooksCognitive-behavioral treatment of irritable bowel syndrome : the brain-gut connection
42 Citations2000Brenda B. Toner
Journal of Clinical GastroenterologyPsychotropic Agents in Irritable Bowel Syndrome
19 Citations2002Arnold Wald
There seems to be sufficient evidence to support the recommendation that psychotropic agents may be effective in two clinical scenarios that are not mutually exclusive: patients with IBS who have pain and related symptoms that are unresponsive to medical therapy and patients with concomitant psychologic dysfunction.
Journal of Psychosomatic ResearchCognitive–behavioral treatment of irritable bowel syndrome
11 Citations2001Juliana Rasic Lachenmeyer, Richard S. Deucher
The Intention-to-Treat Principle for Clinical Trials
2 Citations2001Michael J. Schell, Mary Ann McBride +2 more
The major objective of the randomized clinical trial is to obtain information about the relative efficacy of the treatments involved and randomization is the method used to achieve this goal.
