Cocaine-induced hepatotoxicity in humans
GastroenterologyPublished 1 July 1987
Lloyd E. Perino, George H. Warren, Joel S. Levine
Citations148
SJR quartileQ1
SJR score7.20
SNIP5.04
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Postmortem examination of the liver showed marked periportal inflammation and necrosis, and mild diffuse fatty infiltration, identical to those previously reported in a mouse model of cocaine hepatotoxicity.
Abstract
A patient with hepatonecrosis associated with cocaine use is presented. Postmortem examination of the liver showed marked periportal inflammation and necrosis, and mild diffuse fatty infiltration. These pathologic findings are identical to those previously reported in a mouse model of cocaine hepatotoxicity.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
JAMADeath Caused by Recreational Cocaine Use
236 Citations1984Roger E. Mittleman
Although autopsy findings were generally nonspecific, multiple needle-puncture marks with surrounding ecchymoses are typical of IV cocaine abuse, an increase in cocaine-related overdose deaths is anticipated because of its popularity, increasing availability, and, currently, the increased purity of street cocaine.
CHEST JournalAsystole and Ventricular Fibrillation Associated with Cocaine Intoxication
211 Citations1984Amin A. Nanji, J. Douglas Filipenko
A patient with cocaine intoxication in whom the initial presentation was that of asystole and ventricular fibrillation is discussed, suggesting cocaine intoxication should be considered in any patient with unexplained cardiac arrest or ventricular arrhythmias.
The American Journal of MedicineLiver damage in heatstroke
184 Citations1970Michael C. Kew, I Bersohn +2 more
The effects of heatstroke on the structure and function of the liver have been studied in Bantu gold miners and it is suggested that the hepatic changes are the result of a combination of hypoxia and direct thermal injury.
Archives of NeurologySubarachnoid Hemorrhage Precipitated by Cocaine Snorting
182 Citations1984P. J. Lichtenfeld, D. B. Rubin +1 more
Two cases of subarachnoid hemorrhage that occurred within several minutes of "snorting" cocaine were studied, finding that the bleeding was from an anterior communicating artery aneurysm and an arteriovenous malformation in the temporoparietal region.
PubMedMyocardial ischemia and infarction related to recreational cocaine use.
181 Citations1982Doris Coleman, Tara Ross +1 more
The baby had spent a few days canning fruit and many fruit flies (Drosophila) had been in the house, with probable transfer of fruit juices to the exposed skin, resulting in myiasis.
Annals of Emergency MedicineClinical management of acute and chronic cocaine poisoning
148 Citations1982George R. Gay
The psychodynamics of the "armed" cocaine personality is discussed, as is the proper psychological approach to these patients, and several caveats of therapy that have been clinically developed in the treatment of several hundred cases of cocaine overdose.
The American Journal of CardiologyCocaine-induced angina pectoris and acute myocardial infarction in patients younger than 40 years
131 Citations1985Peter F. Pasternack, Stephen B. Colvin +1 more
3 patients in their 30s who were referred for coronary angiography after having angina pectoris or acute myocardial infarction, or both, coincident with an increase in frequency of cocaine use are described.
PubMedIntestinal ischemia caused by cocaine ingestion: report of two cases.
130 Citations1985Harout I. Nalbandian, N. P. Sheth +2 more
The diagnosis of bowel ischemia should be suspected whenever a cocaine addict has severe abdominal symptoms and signs and the presence of marked leukocytosis suggests bowel gangrene and demands prompt surgical intervention.
Biochemical PharmacologyCocaine-induced hepatic necrosis in mice—The role of cocaine metabolism
121 Citations1979Michael L. Thompson, Louis Shuster +1 more
Results suggest that an active metabolite of N -hydroxynorcocaine may be responsible for the liver damage observed after injection of cocaine into mice, and suggests fairly strict structure requirements for activation.
American Journal of PsychiatryCocaine hallucinations
117 Citations1978Ronald K. Siegel
The author reviews the literature on hallucinations that occur as a result of acute and chronic administration of cocaine and points out the similarity of cocaine hallucinations to entoptic phenomena and migraine hallucinations, which suggests a common mechanism of action based on CNS excitation and arousal.
Toxicology and Applied PharmacologyCocaine-induced hepatotoxicity in mice
104 Citations1978Michael A. Evans, Raymond D. Harbison
Phenobarbital pretreatment protected against this acute cocaine-induced mortality, however, either PB pretreatment or 3-methylcholanthrene pretreatment produced delayed toxicity characterized by hepatic dysfunction and necrosis.
GastroenterologyMidzonal Necrosis as a Pattern of Hepatocellular Injury After Shock
97 Citations1984Suzanne M. de la Monte, Joseph M. Arcidi +2 more
It is concluded that midzonal hepatocellular necrosis may be observed after hypotension, and toxin- or drug-induced injury need not be implicated in the pathogenesis.
British Journal of Addiction to Alcohol & Other DrugsHepatic Dysfunction in Heroin and Cocaine Users
96 Citations1967V. Marks, P. A. L. Chapple
Archives of NeurologySubarachnoid Hemorrhage Precipitated by Cocaine Snorting
93 Citations1984Kenneth A. Schwartz, Jerry A. Cohen
A 23-year-old woman was admitted to the hospital with a fivehour history of the sudden onset of intense head, neck, and eye pain after snorting cocaine, and was described as having no prior history of headaches.
Life SciencesLiver damage from cocaine in mice
88 Citations1977Louis Shuster, Fred W. Quimby +2 more
Massive liver damage and marked elevation of serum glutamic-oxaloacetic transaminase was observed after a single injection of 50 mg per kg cocaine-HC1, which led to increased sleep time after pentobarbital, and a decreased rate of pentobarBital metabolism in vivo.
Annals of Emergency MedicineRenal infarction associated with intravenous cocaine use
81 Citations1984Jeffrey A Sharff
It is postulated that increased adrenergic stimulation from the intravenous cocaine, in association with an existing arterial thrombus, led to end organ infarction, which resulted in transient hypertension, but no long-term morbidity.
PubMedThe shock liver. Clinical and biochemical findings in patients with centrilobular liver necrosis following cardiogenic shock.
74 Citations1978Henrik Birgens, Jens H. Henriksen +2 more
Acta Medica ScandinavicaThe Shock Liver
71 Citations1978Henrik Birgens, Jens H. Henriksen +2 more
Five patients with severe heart disease developed cardiogenic shock of more than 24 hours' duration and severe liver affection was demonstrated, probably hypoxic injury to the centrilobular areas of the liver lobule due to reduced liver blood flow.
Journal of Clinical PathologyEffects of hyperthermia therapy on the liver. II. Morphological observations.
62 Citations1976E. J. Wills, Jacqueline Findlay +1 more
Liver biopsy specimens obtained from three patients during treatment of advanced malignant disease by exogenous hyperthermia were studied and parenchymal cells showed either slight swelling or nuclear alterations by light microscopy and, at the fine structural level, large numbers of autophagic vacuoles, dilatation of Golgi elements and endoplasmic reticulum, and large cytoplasmic vacuole.
Journal of Forensic SciencesThe Forensic Toxicology of Cocaine (1971–1976)
58 Citations1978Bryan S. Finkle, KL McCloskey
A primary, particular objective is to determine whether cocaine is significant as a causative agent in a growing number of sudden, unexplained deaths, and to assess the role of cocaine in postmortem, medieolegal investigation.
Journal of Pharmacology and Experimental TherapeuticsRole of protein binding in cocaine-induced hepatic necrosis.
54 Citations1983Micheal Evans
It is proposed that cocaine is metabolized by microsomal enzymes to a chemically reactive intermediate that binds to hepatic tissue protein to produce liver damage and is species-dependent and associated with binding of the intact norcocaine structure to tissue protein.
PubMedPrevention of acetaminophen and cocaine hepatotoxicity in mice by cimetidine treatment.
47 Citations1983Francis J. Peterson, Robert G. Knodell +2 more
Biochemical PharmacologyHepatic periportal necrosis induced by chronic administration of cocaine
46 Citations1981Richard W. Freeman, Raymond D. Harbison
Chronic administration of cocaine produced a hepatic necrosis that closely resembled that produced by cocaine administered to animals pretreated with stimulators of hepatic metabolism.
The American Journal of MedicineThe phenobarbital sensitivity syndrome
45 Citations1953Thomas E. McGeachy, William E. Bloomer
The use of intravenous procaine and other suggestions for the management of future cases are presented, and possible etiologic mechanisms are briefly discussed.
Diseases of the Colon & RectumCocaine colitis
45 Citations1985Rhonda S. Fishel, Gary Hamamoto +3 more
A mechanism involving chathecholamine-induced mucosal ischemia is postulated to explain the findings seen in this patient, which demonstrated findings consistent with pseudomembranous colitis with an ischemic component.
GastroenterologyPrevention of Acetaminophen and Cocaine Hepatotoxicity in Mice by Cimetidine Treatment
41 Citations1983Francis J. Peterson, Robert G. Knodell +2 more
Current theories regarding production of acetaminophen-induced liver damage require reexamination and the possibility that cimetidine treatment might be useful in preventing hepatic damage due toacetaminophen and other hepatotoxins in humans is intriguing and also warrants consideration.
Archives of Internal MedicineACUTE PHOSPHORUS POISONING
38 Citations1949HYMAN J. RUBITSKY
An investigation of the incidence of phosphorus as a toxic agent and a review of the literature on the subject bring to the foreground its serious nature and menace to the public health.
Clinical toxicologyFatalities from Cocaine Overdoses in Los Angeles County
37 Citations1981George R. Nakamura, Thomas T. Noguchi
JAMAThe Danger of Cocaine
35 Citations1985William Pollin
In rats given free access to heroin or cocaine, cocaine is three times as lethal to them as heroin, and it is essential that the widespread impression that the drug is comparatively benign be rapidly corrected.