Retinal Arteriolar Narrowing, Hypertension, and Subsequent Risk of Diabetes Mellitus
Archives of Internal MedicinePublished 9 May 2005Open access
Tien Yin Wong
Citations149
SJR quartileQ4
SJR score0.11
SNIP0.06
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TL;DR
Retinal arteriolar narrowing is related to risk of incident diabetes, and a possible link between systemic arteriole-to-venule ratio narrowing associated with hypertension and diabetes development is suggested.
Abstract
Retinal arteriolar narrowing is related to risk of incident diabetes. These data suggest a possible link between systemic arteriolar narrowing associated with hypertension and diabetes development.
Keywords
Medicine
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195 Citations1975Jack H. Medalie
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American Journal of OphthalmologyRetinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. Wong TY, Klein R, Sharrett AR, Schmidt MI, Pankow JS, Couper DJ, Klein BEK, Hubbard LD, Duncan BB, for the ARIC Investigators. JAMA 2002;287:2528 -2533.
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