Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice
Journal of NeuroimmunologyPublished 1 March 1991
John F. Sheridan, Ningguo Feng, Robert H. Bonneau, Carl M. Allen, Brandon S. Huneycutt, Ronald Glaser
Citations173
SJR quartileQ2
SJR score0.90
SNIP0.71
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TL;DR
Physical restraint administered to C57BL/6 mice significantly altered the inflammatory response to influenza virus infection and depressed anti-viral cellular immunity, but the magnitude of the humoral immune response to flu virus was unaffected by restraint stress.
Abstract
Physical restraint administered to C57BL/6 mice significantly altered the inflammatory response to influenza virus infection and depressed anti-viral cellular immunity. Restraint-stressed animals showed a pattern of reduced mononuclear cell infiltration and lung consolidation which coincided with elevated plasma corticosterone levels. Furthermore, cellular immunity to virus was significantly depressed; interleukin-2 secretion was reduced by 96% and 59% in the mediastinal lymph nodes and spleens, respectively, as compared to a non-restrained group. However, the magnitude of the humoral immune response to influenza virus was unaffected by restraint stress. Anti-viral IgG antibody levels in restrained/infected mice did not differ when compared to a non-restrained/infected control group 14 days post-infection.
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