Hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Chinese: A case‐control study
International Journal of CancerPublished 1 March 1994
Jung‐Fa Tsai, Jung‐Fa Tsai, Jen‐Eing Jeng, Mei‐Shang Ho, Wen‐Yu Chang, Zu‐Yau Lin
Citations41
SJR quartileQ1
SJR score2.25
SNIP1.76
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Both hepatitis B and C virus infection are independent risk factors for HCC in Chinese in southern Taiwan.
Abstract
To assess whether hepatitis B and C virus infection were risk factors for hepatocellular carcinoma (HCC), antibody to hepatitis C virus (anti-HCV), hepatitis B surface antigen and e antigen (HBsAg and HBeAg) were tested in 150 HCC patients. Another 150 case-control pairs matched individually by sex and age were also enrolled. Univariate analysis demonstrated that both the anti-HCV and the carrier status of HBsAg and HBeAg were significantly associated with HCC. Multi-variate analysis revealed that both anti-HCV and HBsAg were risk factors for HCC. The population-attributable risk was estimated as 14.2% for anti-HCV alone, 59.4% for HBsAg alone and 8.0% for both anti-HCV and HBsAg in Taiwan. In conclusion, both hepatitis B and C virus infection are independent risk factors for HCC in Chinese in southern Taiwan.
Keywords
Medicine
Humana Press eBooksViral Hepatitis and Liver Disease
521 Citations1998Sanjeev Gupta, Michael Ott
The “hepatitic” presentation refers to a significant rise in serum aminotransferases in the presence of normal or minimally increased serum alkaline phosphatase levels.
Digestive Diseases and SciencesHepatocellular carcinoma
385 Citations1991Rosa G Simonetti, Calogero Camm� +4 more
HCC prevention in regions where HBsAg carriage is infrequent may also require prevention of the other causes of cirrhosis in order for HCC rates to decline, as available data suggest that chronic HCV infection is a risk factor for Cirrhosis and HCC.
The Journal of Infectious DiseasesHepatitis C Virus Infection in an Area Hyperendemic for Hepatitis B and Chronic Liver Disease: The Taiwan Experience
328 Citations1990Ding‐Shinn Chen, George Kuo +12 more
HCV infection appears to play a relatively minor role in HBsAg-positive liver disease in Taiwan but is strongly associated with HBs Ag-negative chronic liver disease and HCC.
Seminars in Liver DiseaseRelationship Between Hepatocellular Carcinoma and Cirrhosis
261 Citations1984Michael C. Kew, Hans Pópper
There is at present little evidence for the postulate that HCC is an inevitable consequence of the hyperplasia of cirrhosis, but an etiology common to the two disorders, HBV and possibly other hepatitis viruses, seems to account for the majority of cases.
Hepatitis B Virus Infection, Its Sequelae, and Prevention in Taiwan
95 Citations1987Ding‐Shinn Chen
These statistics reflect the prevalence and importance of chronic liver diseases and HCC in Taiwan and show that HCC was the leading cause of cancer mortality for men and the third for women in 1984.
Liver InternationalHepatitis B and C virus infection as risk factors for liver cirrhosis and cirrhotic hepatocellular carcinoma: a case‐control study
93 Citations1994Jung‐Fa Tsai, Jung‐Fa Tsai +6 more
The result implies that both HBV and HCV are independent risk factors for cirrhotic HCC and liver cirrhosis in Taiwan.
Journal of Medical VirologyHepatitis C virus infection as a risk factor for non‐alcoholic liver cirrhosis in taiwan
64 Citations1993Jung‐Fa Tsai, Jung‐Fa Tsai +10 more
It is shown that hepatitis B and C virus infection act independently and synergistically in the development of non‐alcoholic liver cirrhosis among Chinese in Taiwan.
CancerThe prevalence of anti-hepatitis C virus among chinese patients with hepatocellular carcinoma
57 Citations1992Shou-Dong Lee, Fa-Yauh Lee +4 more
Data indicate that, although HCV may play an etiologic role in HCC, hepatitis B virus is still the most important causal agent among most Chinese patients with HCC.
GastroenterologyRole of hepatitis C virus in acute non-A, non-B hepatitis in Greece: A 5-Year prospective study
48 Citations1992Nicolaos C. Tassopoulos, Angelos Hatzakis +4 more
The data indicate that acute hepatitis due to HCV is characterized by a high rate of chronicity, especially in males, and a non-A, non-B,Non-C agent or a different strain of HCV may be responsible for the majority of the community-acquired cases of non- A,non-B hepatitis in Greece.
Journal of Medical VirologyHepatitis C virus antibody in hepatocellular carcinoma in Taiwan
44 Citations1991Jen‐Eing Jeng, Jung‐Fa Tsai
The results imply that hepatitis C virus may play a role in the pathogenesis of HCC, and there was no statistical difference in sex, age, routine liver function tests, alpha‐fetoprotein concentration, or associated cirrhosis between patients with anti‐HCV and those without.
Epidemiology of primary liver cancer
33 Citations1992Kunio Okuda
The incidence of HCC is much higher among the black population in Mozambique, sub-Saharan Africa, and in the Far East than among Causacians in the United Kingdom, United States, and Australia.
TransfusionThe prevalence of anti‐HCV among Chinese voluntary blood donors in Taiwan
30 Citations1990M. Lin‐Chu, Shu-Chen Tsai +2 more
ALT is the most important surrogate marker for HCV infection in Taiwan, because there is no significant difference in the frequency of anti‐HCV among donors with or without HBV markers.
PubMedEvolution of hepatocellular carcinoma associated with chronic hepatitis B virus infection in Alaskan Eskimos.
29 Citations1988Hans Pópper, Swan N. Thung +4 more
Coordinated morphologic and molecular biologic studies on such animal models and on human HCC detected by screening, as for instance in Eskimos, should elucidate the direction of the evolution of the HCC and the postulated promoting role of the inflammation.
Journal of Gastroenterology and HepatologyPrevalence of anti‐HCV among Chinese patients with acute and chronic liver disease
11 Citations1992Shou‐Dong Lee, Yuan‐Jen Wang +6 more
It is indicated that HCV is a major agent of NANB hepatitis and plays an important role in HBsAg‐negative chronic liver disease in Taiwan.
TransfusionBlood Bank Deficiencies
4 Citations1965Robert E. Klein
The most common deficiencies of Florida blood banks disclosed by inspections during 1964 for renewal of accreditation are indicated.