The EGF receptor as central transducer of heterologous signalling systems
Trends in Pharmacological SciencesPublished 1 October 1999
Esther Zwick, Esther Zwick, Peter O. Hackel, Peter O. Hackel, Norbert Prenzel, Norbert Prenzel
Citations344
SJR quartileQ1
SJR score3.77
SNIP2.99
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TL;DR
The current state of knowledge regarding the role of epidermal growth factor (EGF) in such a network is described and the recent advances made in the elucidation of the mechanism underlying EGF receptor transactivation are discussed.
Abstract
The cross-talk between heterologous signalling systems of the cell represents a new dimension of complexity in the molecular communication network that governs a great variety of physiological processes. In pathophysiologically transformed cells, key elements of this network could offer unique opportunities for pharmacological intervention. In this article, the current state of knowledge regarding the role of epidermal growth factor (EGF) in such a network is described and the recent advances made in the elucidation of the mechanism underlying EGF receptor transactivation are discussed.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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