Normal and pathological oscillatory communication in the brain
Nature reviews. NeurosciencePublished 1 April 2005
Alfons Schnitzler, Joachim Groß
Citations1,278
SJR quartileQ1
SJR score9.33
SNIP5.31
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TL;DR
Improvements in the methods of studying long-range communication have allowed us to address several important questions about how oscillatory synchronization subserve neural communication relates to the structure of the brain.
Abstract
The huge number of neurons in the human brain are connected to form functionally specialized assemblies. The brain's amazing processing capabilities rest on local communication within and long-range communication between these assemblies. Even simple sensory, motor and cognitive tasks depend on the precise coordination of many brain areas. Recent improvements in the methods of studying long-range communication have allowed us to address several important questions. What are the common mechanisms that govern local and long-range communication and how do they relate to the structure of the brain? How does oscillatory synchronization subserve neural communication? And what are the consequences of abnormal synchronization?
Keywords
Neuroscience
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300 Citations1993Å. B. Vallbo, Johan Wessberg
Slow finger movements were analysed in normal human subjects with regard to kinematics and EMG activity of the long finger muscles, suggesting that slow finger movements are implemented by a series of biphasic force pulses, involving not only the shortening agonist muscle propelling the movement, but the antagonist muscle as well whose activity increased shortly after the agonist and contributed to a sharp deceleration of the individual step of movement.
Journal of NeuroscienceEnhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease
299 Citations2002Joshua A. Goldberg, Thomas Boraud +4 more
Abnormal MI firing patterns and synchronization, rather than reduced firing rates, may underlie PD akinesia and persistent muscle rigidity.
The Journal of PhysiologyCortico‐muscular synchronization during isometric muscle contraction in humans as revealed by magnetoencephalography
297 Citations2000J. Gross, Peter A. Tass +4 more
The consistent phase lag between M2 and EMG signals, compatible with conduction time between M1 and the respective muscle with the M1 activity preceding EMG activity, supports the conjecture that the motor cortex drives the motoneuron pool.
Philosophical Transactions of the Royal Society B Biological SciencesThe labile brain. I. Neuronal transients and nonlinear coupling
297 Citations2000Karl Friston
The nature of, and motivation for, neuronal transients is described in relation to characterizing brain dynamics, and it is shown that nonlinear (asynchronous) coupling is, in fact, more abundant and can be more significant than synchronous coupling.
Acta Neurologica ScandinavicaEEG synchronization in mild cognitive impairment and Alzheimer's disease
293 Citations2003Cornelis J. Stam, Yolande van der Made +2 more
To compute the synchronization likelihood of multichannel electroencephalogram data in Alzheimer (AD) patients, subjects with mild cognitive impairment (MCI) and subjects with subjective memory complaints (SC) is studied.
Journal of NeuroscienceSynchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity
288 Citations2002Ron Levy, William D. Hutchison +2 more
The findings indicate that oscillatory synchronization between pairs of GPi or GPe neurons is found in patients with limb tremor and suggest that overt neuronal synchronization, which may be attributable to an increase in direct synaptic connections or common collateral afferent inputs, is not present in the basal ganglia of patients with PD.
Journal of NeuroscienceSynchronous, Focally Modulated β-Band Oscillations Characterize Local Field Potential Activity in the Striatum of Awake Behaving Monkeys
288 Citations2003Richard Courtemanche, Naotaka Fujii +1 more
It is demonstrated that when multiple electrodes are used to record local field potentials, 10-25 Hz oscillations can be readily detected in the striatum of normal macaque monkeys, and it is suggested that the background β-band oscillations in the Striatum could help to focus action-selection network functions of cortico-basal ganglia circuits.
Movement DisordersPathophysiology of dystonia: A neuronal model
283 Citations2002Jerrold L. Vitek
The improvement in dystonia following pallidal lesions is difficult to reconcile with the “rate” hypothesis for hypokinetic and hyperkinetic movement disorders and has led to the development of alternative models that, in addition to rate, incorporate changes in pattern, somatosensory responsiveness and degree of synchronization of neuronal activity.
BrainSubthalamic nucleus, sensorimotor cortex and muscle interrelationships in Parkinson's disease
274 Citations2001J. Marsden, Patricia Limousin‐Dowsey +3 more
Oscillatory activity at 15-30 Hz may prove of use in localizing the subthalamic nucleus target that provides the best clinical effect on stimulation and extend the hypothesis that coherent activity may be useful in binding together related activities in simultaneously active motor centres.
Experimental NeurologyEffects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease
269 Citations2004Peter Brown, Paolo Mazzone +5 more
In two PD patients (3 sides), it is shown that stimulating the subthalamic area at around 20 Hz exacerbates synchronisation at similar frequencies in the globus pallidus interna, the major output structure of the human basal ganglia.
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