Pharmacological Modulation of Behavioral and Neuronal Correlates of Repetition Priming
Journal of NeurosciencePublished 1 September 2001Open access
Christiane M. Thiel, Richard N. Henson, John Morris, Karl Friston, Raymond J. Dolan
Citations95
SJR quartileQ1
SJR score1.96
SNIP1.30
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TL;DR
The results suggest that GABAergic and cholinergic systems influence the neuronal plasticity necessary for repetition priming, using event-related functional magnetic resonance imaging.
Abstract
In this experiment we address the pharmacological modulation of repetition priming, a basic form of learning, using event-related functional magnetic resonance imaging. We measured brain activity in a word-stem completion paradigm in which, before study, volunteers were given either placebo, lorazepam (2 mg orally), or scopolamine (0.4 mg, i.v.). Relative to placebo, both drugs attenuated the behavioral expression of priming. Repetition was associated with a decreased neuronal response in left extrastriate, left middle frontal, and left inferior frontal cortices in the placebo group. Both drugs abolished these "repetition suppression" effects. By showing a concurrence of behavioral and neuronal modulations, the results suggest that GABAergic and cholinergic systems influence the neuronal plasticity necessary for repetition priming.
Keywords
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Human Brain MappingStatistical parametric maps in functional imaging: A general linear approach
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Current Opinion in NeurobiologyProperties and mechanisms of perceptual priming
862 Citations1998Cheri L. Wiggs, Alex Martin
The behavioral and neurophysiological effects of perceptual priming show graded changes with multiple repetition, are resistant to manipulations of particular stimulus attributes, and occur independently of awareness.
Proceedings of the National Academy of SciencesActivation of the hippocampus in normal humans: a functional anatomical study of memory.
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The results provide evidence for selective activation of the human hippocampal region in association with memory function and lead to a suggestion about the neural basis of repetition priming: following presentation of a stimulus, less neural activity is required to process the same stimulus.
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Journal of NeurophysiologyThe representation of stimulus familiarity in anterior inferior temporal cortex
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