Asymmetric Friedel−Crafts Addition of Indoles to <i>N</i>-Sulfonyl Aldimines: A Simple Approach to Optically Active 3-Indolyl-methanamine Derivatives
Organic LettersPublished 16 March 2006
Yi‐Xia Jia, Jian‐Hua Xie, Haifeng Duan, Lixin Wang, Qi‐Lin Zhou
Citations167
SJR quartileQ1
SJR score1.24
SNIP1.03
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Abstract
[reaction: see text] The enantioselective copper(II)-catalyzed Friedel-Crafts addition of indoles to N-sulfonyl aldimines was developed using chiral bisoxazoline as ligands, and high enantioselectivities (up to 96% ee) were achieved.
Keywords
Chemistry
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