Zinc supplementation for improving pregnancy and infant outcome
Cochrane Database of Systematic ReviewsPublished 2 February 2015Open access
Erika Ota, Rintaro Mori, Philippa Middleton, Ruoyan Tobe-Gai, Kassam Mahomed, Celine Miyazaki
Citations370
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TL;DR
The evidence for a 14% relative reduction in preterm birth for zinc compared with placebo was primarily represented by trials involving women of low income and this has some relevance in areas of high perinatal mortality.
Abstract
The evidence for a 14% relative reduction in preterm birth for zinc compared with placebo was primarily represented by trials involving women of low income and this has some relevance in areas of high perinatal mortality. There was no convincing evidence that zinc supplementation during pregnancy results in other useful and important benefits. Since the preterm association could well reflect poor nutrition, studies to address ways of improving the overall nutritional status of populations in impoverished areas, rather than focusing on micronutrient and or zinc supplementation in isolation, should be an urgent priority.
Keywords
MedicineNursing
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Improving prenatal zinc nutrition protected against diarrheal morbidity in infant offspring through 12 months of age.
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35 Citations2001Tsunenobu Tamura, Katherine L. Olin +4 more
Plasma EC-SOD activities did not prove to be a better indicator of zinc nutriture of pregnant women than either plasma zinc or plasma alkaline phosphatase activities and was not a sensitive marker for marginal deficiency status.
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Zinc administration among patients with GDM was associated with decreased hs-CRP and increased TAC concentrations; however, it did not influence maternal plasma nitric oxide (NO), glutathione (GSH), malondialdehyde (MDA) levels, or pregnancy outcomes.
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Zn supplementation was effective in reducing pregnancy complications and early neonatal infection among the Zn-deficient women of the present trial.
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31 Citations2005Aqsa Hafeez, G Mehmood +1 more
A double blind, randomised case-control study was carried out on pregnant women to evaluate the effects of oral zinc supplementation on the weights of newborns, finding no significant difference in the birth weights between the cases supplemented with 20 mg elemental zinc and controls receiving oral placebos.
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Based on the findings, 15-mg zinc supplementation daily from 16 weeks of pregnancy until delivery cannot improve pregnancy outcomes.
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28 Citations2010Laura E. Caulfield, Nelly Zavaleta +6 more
Differences in cardiac patterns due to prenatal zinc supplementation were detectable in children at 54 mo of age during conditions of both rest and challenge, indicating that supplementing zinc-deficient pregnant women has beneficial long-term consequences for neural development associated with autonomic regulation.
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27 Citations2001Parul Christian, Subarna K. Khatry +4 more
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International Journal for Vitamin and Nutrition ResearchThe Impact of Prenatal Vitamin A and Zinc Supplementation on Birth Size and Neonatal Survival - a Double-Blind, Randomized Controlled Trial in a Rural Area of Indonesia
25 Citations2013Endy Paryanto Prawirohartono, Lennarth Nyström +3 more
Prenatal zinc or vitamin A supplementation demonstrates a small but significant effect onBirth length, but supplementation with zinc, vitamin A or a combination of zinc and vitamin A, have no effect on birth weight, neonatal morbidity, or mortality.
American Journal of Obstetrics and GynecologyThe effect of diet supplementation and addition of zinc in vitro on the growth-supporting property of amniotic fluid in African women
25 Citations1979Peter C. Appelbaum, Samuel M. Ross +2 more
Although zinc levels in liquor rose following dietary zinc supplementation, these remained lower than values described in white patients, and in vitro addition of zinc to 17 noninhibitory African liquors resulted in these fluids becoming inhibitory.
East African Journal of Public HealthEffect Of Joint Iron And Zinc Supplementation On Malarial Infection And Anaemia
24 Citations2009Mahama Saaka, Jacques Oosthuizen +1 more
Joint iron and zinc supplementation appears to be a better option than iron-only supplementation in malaria-endemic areas.
Public Health NutritionThe impact of prenatal vitamin A and zinc supplementation on growth of children up to 2 years of age in rural Java, Indonesia
23 Citations2011Endy Paryanto Prawirohartono, Lennarth Nyström +3 more
Prenatal vitamin A supplementation had a small but significant effect on postnatal growth of children's length until 18 months of age compared with supplementation with either vitamin A + Zn or Zn alone, but not compared with placebo.
The Journal of Maternal-Fetal & Neonatal MedicineEffects of zinc supplementation during pregnancy on pregnancy outcome in women with history of preterm delivery: A double-blind randomized, placebo-controlled trial
22 Citations2010Azar Danesh Shahraki, Mohsen Janghorbani +1 more
Adding Zn supplementation during pregnancy to routine care of women with a previous preterm delivery had no significant effect on the gestational age at delivery and birth weight but increased the birth head circumference.
European Journal of NutritionMaternal zinc supplementation improves hepatitis B antibody responses in infants but decreases plasma zinc level
21 Citations2015Shaikh Meshbahuddin Ahmad, Mohammad Bakhtiar Hossain +6 more
Prenatal and postnatal zinc supplementation marginally improved T cell-dependent antibody responses in infants along with IL-7, a cytokine involved in human T cell development and maintaining homeostasis in a population at risk of deficiency.
PubMedZinc taste test in pregnant women and its correlation with serum zinc level.
18 Citations1993Hemant Garg, K C Singal +1 more
On the whole, zinc taste test was well correlated with serum zinc level, and provides a fair idea of zinc deficiency, and helps to assess body zinc status by 'zinc taste test'.
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