A guideline for the treatment and prevention of NSAID-induced ulcers
The American Journal of GastroenterologyPublished 1 November 1998
Frank L. Lanza
Citations279
SJR quartileQ1
SJR score2.34
SNIP2.27
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TL;DR
Guidelines for clinical practice are intended to indicate preferred approaches to medical problems as established by scientifically valid research and are applicable to all physicians who address the subject without regard to specialty training or interests.
Abstract
Lanza, Frank L MD, FACG the Members of the Ad Hoc Committee on Practice Parameters of the American College of Gastroenterology Author Information
Keywords
Medicine
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1,019 Citations1993Ingvar Bjarnason, Jeremy Hayllar +2 more
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The LancetRisk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs
976 Citations1994La García Rodríguez, Hershel Jick
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958 Citations1992M C Allison, Allan G. Howatson +3 more
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874 Citations1994M. J. S. Langman, J Weil +7 more
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New England Journal of MedicineOmeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs
862 Citations1998Christopher J. Hawkey, Jeffrey A. Karrasch +5 more
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New England Journal of MedicineA Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs
768 Citations1998Neville D. Yeomans, Zsolt Tulassay +6 more
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Annals of Internal MedicineNonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons
764 Citations1991Marie R. Griffin, Joyce M. Piper +3 more
The data support other findings indicating that a clinically significant risk for serious ulcer disease is associated with the use of nonaspirin nonsteroidal anti-inflammatory drugs and that use of these drugs may be responsible for a large proportion of peptic ulcers among elderly persons.
GutNon-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.
631 Citations1987C P Armstrong, A L Blower
There appears to be a relationship between the development of a life threatening complication of peptic ulceration and NSAID ingestion and much of the associated mortality and morbidity may be potentially avoidable.
Annals of Internal MedicineCorticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs
603 Citations1991Joyce M. Piper, Wayne A. Ray +2 more
The high risk for peptic ulcer disease associated with combined use of NSAIDs and corticosteroids indicates the need to prescribe this drug combination cautiously.
The LancetPREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
598 Citations1988D.Y. Graham, NaurangM Agrawal +1 more
Results provide the first clear indication that NSAID-induced ulcers are preventable, and Mild to moderate, self-limiting diarrhoea was the most frequently reported adverse effect attributed to misoprostol.
The LancetNON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCER
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Differences in drug intake were evident for both gastric and duodenal ulcer, and are likely to be important in view of the widespread use of these drugs in elderly people.
New England Journal of MedicineFamotidine for the Prevention of Gastric and Duodenal Ulcers Caused by Nonsteroidal Antiinflammatory Drugs
440 Citations1996Ali S. Taha, N Hudson +8 more
Treatment with high-dose famotidine significantly reduces the cumulative incidence of both gastric and duodenal ulcers in patients with arthritis receiving long-term NSAID therapy.
Annals of Internal MedicineNonsteroidal Anti-Inflammatory Drug Use and Death from Peptic Ulcer in Elderly Persons
422 Citations1988Marie R. Griffin, Wayne A. Ray +1 more
The findings of this study add to the growing evidence that NSAIDs can increase the risk for clinically serious peptic ulcer disease in the elderly.
The LancetRisk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product
418 Citations1996Judith P. Kelly, David W. Kaufman +4 more
Use of low doses of enteric-coated or buffered aspirin carries a three-fold increase in the risk of major UGIB, suggesting the assumption that these formulations are less harmful than plain aspirin may be mistaken.
The LancetRandomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers
409 Citations1997Francis K.L. Chan, Joseph J.�Y. Sung +8 more
Eradication of H pylori before NSAID therapy reduces the occurrence of NSAID-induced peptic ulcers in patients with musculoskeletal pain.
Annals of Internal MedicineNonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease
401 Citations1991Andrew H. Soll, Wilfred M. Weinstein +2 more
Nonsteroidal anti-inflammatory drugs thus appear both to exacerbate an underlying peptic diathesis and to cause de novo ulcers.
New England Journal of MedicineEffect of Omeprazole and Ranitidine on Ulcer Healing and Relapse Rates in Patients with Benign Gastric Ulcer
382 Citations1989A. Walan, John P. Bader +5 more
A double-blind multicenter study of 602 patients with benign gastric or prepyloric ulcers to compare the effectiveness of omeprazole and ranitidine in promoting ulcer healing and to evaluate the pattern of ulcer relapse during a six-month follow-up concludes that in the dose used, omepazole is superior to ranitidine in the treatment of benign Gastric ulcers.
BMJPrevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.
381 Citations1988R. S. B. Ehsanullah, M. C. Page +2 more
Ranitidine 150 mg twice daily significantly reduced the incidence of duodenal ulceration but not gastric ulcers when prescribed concomitantly with one of four commonly used non-steroidal anti-inflammatory drugs.
Journal of Clinical PathologyDiaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs.
361 Citations1988J Láng, Ashley B. Price +4 more
A spectrum of patterns was found from multiple pathognomonic ileal mucosal diaphragms to broad strictures similar to those seen as a complication of enteric potassium, which may reflect the increasing use of these compounds.
The American Journal of MedicineNonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models
357 Citations1991James F. Fries, Catherine A. Williams +2 more
Knowledge of the risk factors for NSAID-associated gastropathy and their inter-relationships provides a tool for identification of the patient at high risk and for initiation of appropriate therapeutic action.
GastroenterologyNonsteroidal antiinflammatory drug-induced intestinal inflammation in humans
355 Citations1987Ingvar Bjarnason, G. D. Zanelli +7 more
It appears that nonsteroidal antiinflammatory drugs cause small intestinal inflammation in two-thirds of patients on long-term treatment and on discontinuation, the inflammation may persist for up to 16 mo.
The LancetRISING FREQUENCY OF ULCER PERFORATION IN ELDERLY PEOPLE IN THE UNITED KINGDOM
352 Citations1986Robert P. Walt, Richard F. Logan +3 more
Analysis of the most recently available data shows that trends in peptic ulcer admission rates have continued in England and Wales and similar trends are seen in the elderly populations in Scotland.
Annals of Internal MedicineNonsteroidal Anti-Inflammatory Drugs Activate Quiescent Inflammatory Bowel Disease
350 Citations1987Herbert J. Kaufmann, HOWARD L. TAUBIN
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343 Citations1985M J Langman, Larissa E. Morgan +1 more
Patients with perforation or haemorrhage were more than twice as likely to be takers of anti-inflammatory drugs, but no association was detected with the intake of other types of drugs, particularly cardiovascular drugs.
Archives of Internal MedicineRisk of Hospitalization for Upper Gastrointestinal Tract Bleeding Associated With Ketorolac, Other Nonsteroidal Anti-inflammatory Drugs, Calcium Antagonists, and Other Antihypertensive Drugs
336 Citations1998L.A. García Rodríguez, Chiara Cattaruzzi +2 more
The excess risk of major upper gastrointestinal tract complications associated with outpatient use of ketorolac suggests an unfavorable risk-benefit assessment compared with other NSAIDs.
The LancetUpper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs
323 Citations1991J-R Laporte, Xavier Carné +3 more
The odds ratio estimate for aspirin taken at least once during the week before the first symptom was 7·2 (95% confidence interval 5·4-9·6), and a previous history of gastrointestinal bleeding or peptic ulcer did not greatly affect odds ratio estimates, which differed according to sex and were higher for younger than for older patients.
GastroenterologyNonsteroidal anti-inflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation
322 Citations1997BK Reuter, NM Davies +1 more
Enterohepatic recirculation of NSAIDs is of paramount importance in the pathogenesis of enteropathy caused by these drugs, whereas suppression of prostaglandin synthesis is relatively unimportant.
Annals of Internal MedicineIncidence of Gastric Lesions in Patients with Rheumatic Disease on Chronic Aspirin Therapy
321 Citations1979G.R. Silvoso, K. J. IVEY +7 more
Regular aspirin and buffered aspirin users had an ulcer incidence of 23% and 31% respectively, compared with a 6% incidence in enteric-coated aspirin users (P less than 0.05).
Archives of Internal MedicineConcurrent Use of Nonsteroidal Anti-inflammatory Drugs and Oral Anticoagulants Places Elderly Persons at High Risk for Hemorrhagic Peptic Ulcer Disease
319 Citations1993Ronald I. Shorr
The nearly 13-fold increase in the risk of developing hemorrhagic peptic ulcer disease in concurrent users of oral anticoagulants and NSAIDs suggests that NSAIDs should be prescribed with extreme caution in patients undergoing anticoageulation therapy.
The LancetINTESTINAL PERMEABILITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS: EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
307 Citations1984Ingvar Bjarnason, Alex So +6 more
Although increased intestinal permeability does not seem to be important in the pathogenesis of rheumatoid arthritis, the administration of NSAIDs may lead to loss of intestinal integrity, thus facilitating antigenic absorption and perhaps contributing to persistence of the disease.
Annals of Internal MedicineDuodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs
297 Citations1993David Y. Graham, Richard H. White +9 more
The efficacy of misoprostol is investigated for the prevention of NSAID-induced duodenal ulcers in arthritis patients receiving long-term NSAID therapy.
GastroenterologyVariability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs
278 Citations1993David Henry, Annette J. Dobson +1 more
A number of factors can alter the risk of major gastrointestinal complications with NANSAIDs and need to be considered when individual prescribing decisions are made.
GutNon-steroidal anti-inflammatory drugs and peptic ulcer perforation.
276 Citations1985Dean Collier, J A Pain
It is suggested that the elderly especially women are unduly susceptible to NSAID associated peptic ulcer perforation, and factors that may account for this are discussed.
GutEffect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine.
270 Citations1986Ingvar Bjarnason, Peter Williams +3 more
The studies show that non-steroidal anti-inflammatory drugs disrupt the intestinal barrier function in man and suggest that the morphological correlates of the damage may reside at the level of the intercellular junctions.
New England Journal of MedicineEndoscopic Evaluation of the Effects of Aspirin, Buffered Aspirin, and Enteric-Coated Aspirin on Gastric and Duodenal Mucosa
261 Citations1980Frank L. Lanza, George Royer +1 more
The damaging effect of aspirin on the gastric mucosa has been well documented by endoscopy and studies of fecal blood loss and because of the unquestioned value of aspirin in the treatment of rheumatoid arthritis.
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249 Citations1997JEFF EVANS, Alex D. McMahon +3 more
The use of NSAIDs may be associated with an increased risk of emergency admission to hospital for colitis due to inflammatory bowel disease, particularly among patients with no previous history.
Digestive Diseases and SciencesEffect of ranitidine gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs
240 Citations1989Malcolm Robinson, Joseph Griffin +5 more
While ranitidine is an effective prophylaxis for NSAID-induced damage in the duodenum, further studies are needed to define specific risk groups and to assess the potential usefulness of more complete acid suppression in preventing gastric mucosal damage.
Scandinavian Journal of GastroenterologyPrevention of Peptic Ulcer and Dyspeptic Symptoms with Omeprazole in Patients Receiving Continuous Non-Steroidal Anti-Inflammatory Drug Therapy: A Nordic Multicentre Study
226 Citations1996Per Ekström, L. Carling +6 more
Omeprazole, 20 mg once daily, provides effective prophylactic therapy in patients at risk of developing NSAID-associated peptic ulcers or dyspeptic symptoms in patients with a history of dyspepsia or uncomplicated peptic Ulcer disease.
GastroenterologyClinicopathological features of nonsteroidal antiinflammatory drug-induced small intestinal strictures
215 Citations1988Ingvar Bjarnason, Ashley B. Price +5 more
The clinicopathological features in 4 patients are described where nonsteroidal antiinflammatory drugs appear to have caused small intestinal strictures, and the histopathological picture appears to represent a new nosological entity.
GastroenterologyEvidence of aspirin use in both upper and lower gastrointestinal perforation
200 Citations1997Ángel Lanas, P. Serrano +4 more
NSAID use is strongly associated with an increased risk of both upper and lower gastrointestinal perforation and the high prevalence of aspirin (over-the-counter) use suggests that future introduction of new NSAIDs may not have a major impact on decreasing gastrointestinal complications if other measures are not taken.
Annals of Internal MedicineMisoprostol Dosage in the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Gastric and Duodenal Ulcers: A Comparison of Three Regimens
189 Citations1995Jeffrey B. Raskin, Richard H. White +5 more
The effectiveness and tolerability of three different misoprostol regimens were determined, which were shown to provide significant protection against NSAID-induced gastric and duodenal ulcers and to reduce the incidence of ulcer complications.
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177 Citations1987Claude Cuvelier, Calypso Barbatis +4 more
This study has identified a group of patients with inflammatory chronic, or relapsing acute arthritis who even in the absence of gastrointestinal symptoms have histological evidence of ileocolitis.
Annals of Internal MedicineMisoprostol Compared with Sucralfate in the Prevention of Nonsteroidal Anti-inflammatory Drug-induced Gastric Ulcer
170 Citations1991Naurang M. Agrawal, Sanford H. Roth +5 more
GutAnalgesic ingestion and other factors preceding relapse in ulcerative colitis.
162 Citations1983D S Rampton, N. I. McNeil +1 more
The surprisingly high prevalence of analgesic ingestion before relapse itself requires confirmation but does lend indirect support to the theory that colonic mucosal prostaglandin deficiency induces relapse in some patients with ulcerative colitis.
The LancetEnteroscopic diagnosis of small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs
160 Citations1991A. Morris, John Mackenzie +3 more
15 patients with rheumatoid arthritis who were receiving non-steroidal anti-inflammatory drugs (NSAIDs) and who had chronic occult gastrointestinal bleeding underwent extended small bowel examination with a Sonde enteroscope and 7 patients were found to have jejunal or ileal ulceration.
GutRanitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers.
149 Citations1991Michael Lancaster-Smith, Magnus Jäderberg +1 more
It is shown that ranitidine 150 mg twice daily effectively heals NSAID associated peptic ulcers and Healing is more successful when NSAID treatment stops but even if these drugs are continued, substantial healing rates are achievable.
Archives of Internal MedicineColitis induced by nonsteroidal anti-inflammatory drugs. Report of four cases and review of the literature
142 Citations1992G. R. Gibson
GutRole of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users. Response to omeprazole dual therapy.
139 Citations1996G. Bianchi Porro, F. Parente +3 more
H pylori eradication does not confer any significant advantage on the healing of gastric and duodenal ulcers associated with longterm NSAID use and it remains to be established with certainty whether eradication may be helpful in the reduction of recurrence in a specific subset of NSAID associated ulcer.
Journal of General Internal MedicineExcess costs from gastrointestinal disease associated with nonsteroidal anti-inflammatory drugs
134 Citations1996Walter Smalley, Marie R. Griffin +2 more
Nonsteroidal anti-inflammatory drug (NSAID) use in elderly patients was associated with substantial excess costs and utilization of medical care for gastrointestinal disorders.
GutPeptic ulcer bleeding in the elderly: relative roles of <i>Helicobacter pylori</i> and non-steroidal anti-inflammatory drugs
134 Citations1997D J E Cullen, G M Hawkey +5 more
H pylori effects ulcer bleeding in an adverse manner but does not make the risk of NSAIDs worse, andNSAID usage increased risk substantially.
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131 Citations1995Jim Slattery, Charles Warlow +2 more
Analysis of patients enrolled in the UK TIA trial suggested greater risks of bleeding from duodenal ulcers than gastric ulcers and that bleeding is more likely early in the course of treatment with aspirin used as secondary prevention.
GastroenterologyFamotidine for healing and maintenance in nonsteroidal anti- inflammatory drug-associated gastroduodenal ulceration
127 Citations1997N Hudson, Ali S. Taha +7 more
High-dose famotidine is effective ulcer healing therapy in patients who stop or continue NSAID treatment and significantly reduced the cumulative incidence of gastroduodenal ulcer recurrence compared with placebo when given as maintenance therapy.
Scandinavian Journal of GastroenterologyA Review of Gastric Ulcer and Gastroduodenal Injury in Normal Volunteers Receiving Aspirin and Other Non-Steroidal Anti-Inflammatory Drugs
125 Citations1989Frank L. Lanza
The largest number of ulcers were seen with plain and buffered aspirin, and the lowest number with the lower anti-inflammatory doses of the non-aspirin NSAIDs.
British journal of surgeryNon-steroidal anti-inflammatory drugs and complicated diverticular disease: A case—control study
125 Citations1991Karen Campbell, R. Steele
Of the 50 study patients, 24 were taking non‐steroidal anti‐inflammatory drugs (NSAIDs) at the time of admission compared with nine of control groups A and ten of control group B, indicating a strong association between the ingestion of NSAIDs and the development of severe complications of diverticular disease.
Journal of Clinical GastroenterologyThe Effect of Chronic Aspirin Use on Duodenal and Gastric Ulcer Hospitalizations
119 Citations1990John H. Kurata, David E. Abbey
It is concluded that chronic aspirin use is a risk factor for hospitalization for both duodenal and gastric ulcer in males, and for peptic ulcers in males and females.
Gastroenterology Clinics of North AmericaTHE RISKS AND COSTS OF UPPER GASTROINTESTINAL DISEASE ATTRIBUTABLE TO NSAIDS
105 Citations1996Walter Smalley, Marie R. Griffin
The increased risks for adverse upper GI hemorrhage and peptic ulcer disease associated with NSAID use have been demonstrated in observational studies and clinical trials; an overview of these results is presented.
Lara D. VeekenINCREASED INTESTINAL PERMEABILITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: A SIDE-EFFECT OF ORAL NONSTEROIDAL ANTI-INFLAMMATORY DRUG THERAPY?
103 Citations1987Reed T. Jenkins, Patrick J. Rooney +3 more
Intestinal permeability in patients with active rheumatoid arthritis was found to be significantly increased in comparison to controls, and it has not been determined beyond doubt whether this finding is due to disease process or therapy with oral NSAIDs.
Digestive Diseases and SciencesA double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects
102 Citations1986Frank L. Lanza
In conclusion, misoprostol is effective in preventing gastric and duodenal mucosal injury induced by tolmetin and, perhaps, by other nonsteroidal antiinflammatory drugs as well.
British journal of surgeryComplications of diverticular disease and non-steroidal anti-inflammatory drugs: A prospective study
97 Citations1990R. G. Wilson, A. N. Smith +1 more
Patients admitted with complications of diverticular disease have a high incidence of NSAID intake, and it appears that NSAID consumption is associated with a more severe form of the disease.
Archives of Internal MedicineMajor upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics
94 Citations1988Micha Levy
Digestive Diseases and SciencesOmeprazole ameliorates aspirin-induced gastroduodenal injury
80 Citations1994James M. Scheiman, Elizabeth M. Behler +2 more
Omeprazole, 40 mg/day eliminates duodenal injury and markedly ameliorates gastric injury due to administration of aspirin 2600 mg/ day, and prophylaxis of NSAID injury deserves further study.
GutPrevalence of Helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis.
77 Citations1993Patrick Goggin, D A Collins +5 more
It is concluded that H pylori infection is associated with increased dyspeptic symptoms in patients receiving NSAIDs but that it does not potentiate NSAID gastropathy.
Scandinavian Journal of RheumatologyEfficacy of 12 Months' Misoprostol as Prophylaxis against IMSAID-induced Gastric Ulcers:<i>A placebo-controlled trial</i>
76 Citations1994S. L. Elliott, Neville D. Yeomans +2 more
It is concluded that misoprostol decreases the cumulative development of NSAID-induced gastric ulcers and gastroduodenal erosions in arthritis patients on chronic NSAID therapy.
Archives of Internal MedicineEffects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage
76 Citations1992Byron Cryer
Prostaglandins, their functions in the gastrointestinal tract, anti-inflammatory actions of NSAIDs, and mechanisms by which NSAIDs produce gastroduodenal ulcers are discussed.
GutDuodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs.
71 Citations1993Ali S. Taha, S Dahill +4 more
It is concluded that active duodenitis is less common in patients taking NSAIDs but is strongly associated with gastric metaplasia, H pylori positive gastritis, andduodenal ulceration.
Alimentary Pharmacology & TherapeuticsMeta‐analysis of randomized controlled trials as a method of estimating rare complications of non‐steroidal anti‐inflammatory drug therapy
67 Citations1988T. C. Chalmers, Jayne Berrier +5 more
Risk differences were pooled using the DerSimonian and Laird method, which weights studies inversely according to variance, and only the unspecified gastric symptoms for non‐aspirin non‐steroidal anti‐inflammatory drugs (NA—NSAIDs) and the haemorrhage for aspirin were found to be statistically significant.
GutHelicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy.
65 Citations1992D. Héresbach, Jean‐Luc Raoul +6 more
Data suggest that H pylori may be a risk factor of NSAID induced gastropathy and is associated with chronic active gastritis.
GastroenterologyMisoprostol Reduces Gastroduodenal Injury From One Week of Aspirin: An Endoscopic Study
64 Citations1989Geoffrey C. Jiranek, Michael B. Kimmey +4 more
It is concluded that misoprostol can protect the normal gastroduodenum from acute ulceration and reduce the chance of erosion after 1 wk of aspirin ingestion.
Lara D. VeekenA Long-Term Study to Evaluate the Safety and Efficacy of Meloxicam Therapy in Patients with Rheumatoid Arthritis
62 Citations1996E.C. HUSKISSON, R Ghozlan +3 more
Meloxicam 15 mg once daily was effective and compared favourably with standard NSAIDs regarding tolerance when administered to patients with RA over an 18 month period.
Gastrointestinal EndoscopyThe prevalence of duodenal lesions in patients with rheumatic diseases on chronic aspirin therapy
58 Citations1980O.O. Lockard, K.J. Ivey +4 more
Peroral endoscopy was performed in 56 patients with rheumatic disease who had been taking 8 or more aspirin tablets daily for more than 3 months yet who had no major gastrointestinal symptoms or history of peptic ulcer disease.
The American Journal of MedicineProtection by misoprostol against naproxen-induced gastric mucosal damage
54 Citations1987E. Aadland, O. Fausa +3 more
It is clear that misoprostol protects the gastric mucosa of humans against naproxen-induced damage, and the scores for erosive and bleeding lesions in the antrum and corpus/fundus of the stomach were all reduced by administration of misop frostol.
Lara D. VeekenTHE PREVENTION AND HEALING OF ACUTE NON-STEROIDAL ANTI-INFLAMMATORY DRUG-ASSOCIATED GASTRODUODENAL MUCOSAL DAMAGE BY MISOPROSTOL
52 Citations1993Karna Dev Bardhan, Ingvar Bjarnason +5 more
Endoscopic findings did not correlate significantly with gastrointestinal symptoms and misoprostol did not interfere with the NSAID efficacy, and misOProstol significantly reduces the incidence of significant GD damage early in the course of NSAID treatment.
Gastrointestinal EndoscopyUlcerations of the colon associated with naproxen and acetylsalicylic acid treatment
50 Citations1986A. Uribe, C. Johansson +2 more
Archives of Internal MedicineNizatidine Prevents Peptic Ulceration in High-Risk Patients Taking Nonsteroidal Anti-inflammatory Drugs
48 Citations1993Louise R. Levine
It was showed that nizatidine, 150 mg, twice daily, significantly reduces the incidence of ulcer formation in high-risk patients taking long-term NSAID therapy, and also relieves NSAID-associated dyspeptic symptoms in some patients.
Age and AgeingNONSTEROIDAL ANTI-INFLAMMATORY DRUGS, ARTHRITIS, AND GASTRO INTESTINAL BLEEDING IN ELDERLY IN-PATIENTS
47 Citations1984T. H. Caradoc‐Davies
It is suggested that simple analgesics such as paracetamol should be used for maintenance therapy of osteoarthritis in the elderly, with NSAIDs being reserved for treatment of true arthritis in selected patients.
Alimentary Pharmacology & TherapeuticsHigh‐dose ranitidine for the prevention of recurrent peptic ulcer disease in rheumatoid arthritis patients taking NSAIDs.
46 Citations1996S. ten Wolde, BA Dijkmans +3 more
High dose ranitidine is effective for the prevention of recurrent duodenal ulcer but not for recurrent gastric ulcer in rheumatoid arthritis patients taking NSAIDs.
Scandinavian Journal of RheumatologyHelicobacter pylori Infection Increases the Risk of Peptic Ulcers in Chronic Users of Non-steroidal Anti-inflammatory Drugs
32 Citations1996E. K. M. Li, Joseph J.�Y. Sung +7 more
H. pylori infected chronic NSAID users is associated with a higher rate of duodenal ulcer and the difference in severity and frequency of dyspeptic symptoms between the two groups did not reach statistical significance.
RadiologyBenign Ulcer of the Sigmoid Colon
32 Citations1968Anthony J. Bravo, Robert M. Lowman
A report of this entity seems indicated so that radiologists will be aware of it, may differentiate it from malignant lesions, and may consider it in patients being treated with known ulcerogenic drugs.
Archives of Internal MedicineThe relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs
31 Citations1987J. L. Carson
BMJRectal Bleeding and Indomethacin
27 Citations1968John Walls, D. N. Bell +1 more
It is estimated that no fewer than 800,000 women in this kingdom are taking oral contraceptives, so if 80 women develop alopecia areata this amounts to no more than the normal incidence of 1 in 10,000, which is closely similar to the incidence in the general population.
Digestive Diseases and SciencesPersistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin
23 Citations1989Richard Jaszewski, Ricardo Calzada +1 more
An eight-week course of cimetidine and antacids is ineffective in completely healing gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory drugs while enteric-coated aspirin is continued.
Lara D. VeekenRANITIDINE IN THE TREATMENT OF GASTRIC AND DUODENAL ULCERS ASSOCIATED WITH NON-STEROIDAL ANTI INFLAMMATORY DRUGS
19 Citations1993G Tildesley, R. S. B. Ehsanullah +1 more
Healing rates were uninfluenced by gender, age, smoking habits, alcohol consumption, ulcer frequency or size, arthritic disease, or participating country.
Rheumatology InternationalLarge-scale open trials with etodolac (Lodine®) in France: An assessment of safety
18 Citations1990C. L. Benhamou
Two large-scale open-label studies performed in France confirmed the very acceptable risk/benefit ratio of etodolac and rank this drug high for efficacy and safety among the NSAIDs recently introduced in France.
DrugsAn Overview of the Long Term Safety Experience of Nabumetone
18 Citations1990Robert F. Willkens
Overall, nabumetone was well tolerated, and the adverse experience profile was clinically acceptable and presented no unusual or unexpected patterns.
Archives of Internal MedicineRisk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs
18 Citations1989Bernard S. Bloom
DrugsA 12-Month Postmarketing Surveillance Study of Nabumetone
14 Citations1990Paul N. Jenner
Evaluation of all serious events, including death, identified 11 events in 10 800 patients (0.1%) which could possibly be related to nabumetone therapy, and seven of these were gastrointestinal haemorrhage.
Scandinavian Journal of GastroenterologyNizatidine in Therapy and Prevention of Non-steroidal Antiinflammatory Drug-induced Gastroduodenal Ulcer in Rheumatic Patients
14 Citations1994Bernd Simon, Peter Müller
There was a tendency to higher healing rates in the case of gastric ulcers after 4 weeks following the higher dose of nizatidine, and erosion, in the stomach and duodenum as well as oesophagitis, improved to a similar degree with all niz atidine doses.
Scandinavian Journal of GastroenterologySulglycotide in the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Gastroduodenal Mucosal Injury: A Controlled Double-Blind, Double-Dummy, Randomized Endoscopic Study versus Placebo in Rheumatic Patients
10 Citations1993G. Bianchi Porro, F Montrone +3 more
It is suggested that sulglycotide prophylaxis may be useful for the prevention of gastric and duodenal ulcer associated with NSAID therapy in rheumatic patients.
DrugsGerman Drug Monitoring Studies with Nabumetone
9 Citations1990I. Stroehmann, M. Fedder +1 more
Nabumetone can be classified as an effective and safe NSAID and it is unlikely that any unexpected side effects will occur in the future.
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