Top Research Papers on Organic Chemistry

Metal-organic frameworks (MOFs) are porous, crystalline solids constructed from organic linkers and inorganic nodes that have been widely studied for applications in gas storage, chemical separations, and drug delivery. Owing to their highly modular structures and tunable pore environments, we propose that MOFs have significant untapped potential as catalysts and reagents relevant to the synthesis of next-generation therapeutics. Herein, we outline the properties of MOFs that make them promising for applications in synthetic organic chemistry, including new reactivity and selectivity, enhanced...

bonding. The study of structure determines their chemical composition and formula and the study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical (in silico) study.

ConspectusCurrent global crises related to clean energy and the environment entail the development of materials that are capable of addressing these challenges. Metal-organic frameworks (MOFs), a class of functional materials assembled from metal-containing nodes and organic ligands via coordination bonds, have been successfully developed for various applications, including catalysis, toxic chemical removal, and gas storage and separation, as a result of their highly tailorable nature and precisely engineered pore structures. In particular, the exceptionally high surface areas and porosities o...

Before the covid-19 pandemic paradigm, the education sector has been facing several challenges. Especially in the Chemistry area, the subjectivity and complexity conditions are admitted by many students when it is about teaching the content of this science. Furthermore, the promotion of active methodologies for teaching Inclusive Chemistry is deficient, mainly, methodologies which contemplate the particularities of the deaf community. In this context, the purpose of the present work is to offer remote teaching activities that addressed the content of Organic Chemistry in a contextualized way w...

Selenium, originally described as a toxin, turns out to be a crucial trace element for life that appears as selenocysteine and its dimer, selenocystine. From the point of view of drug developments, selenium-containing drugs are isosteres of sulfur and oxygen with the advantage that the presence of the selenium atom confers antioxidant properties and high lipophilicity, which would increase cell membrane permeation leading to better oral bioavailability. In this article we have focused on the relevant features of the selenium atom, above all, the corresponding synthetic approaches to access a v...

The main properties of boron-containing compounds, their preparation by organic synthesis, as well as their applications in organic synthesis and medicinal chemistry fields are discussed, developing new perspectives for further investigations.

A physical organic chemist wants to understand the detailed sequence of bond makings and bond breakings by which new or well-known reactions take place, and to identify any metastable intermediates involved.

Simple Summary Fossils of dinosaurs other than birds are at least 66 million years old. Nevertheless, many organic compounds have survived fossilization and can still be found in the fossils. This article describes the discovery of organic molecules in dinosaur fossils. It provides a review of the analytical methods used for their detection and characterization, and presents the wide range of chemical organic compounds, including small molecules and polymers, that have been found in dinosaurs to date. The difficulties in unambiguously confirming the presence of some of the organic molecules in...

Nanocatalysts with superior characteristics regarding activity, selectivity, durability, and recoverability, are envisaged playing a pivotal role to enable a wealth of future applications and contribute to solve current environmental, social, and industrial problems [...]

Trends in the function of time, reaction-type "popularity" and complexity based on the algorithm that extracts generalized reaction class templates are studied, useful in the context of computer-assisted synthesis, machine learning, and also for identifying erroneous entries in reaction databases.

Combined efforts from molecular biology, systems biology, organic chemistry and chemical engineering will establish a whole new toolbox for chemistry.

This Perspective discusses ways to further lower the barriers for the adoption of biocatalysis by the broader synthetic organic chemistry community through the dissemination of resources, demystifyingBiocatalytic reactions, and increasing collaboration across the field.

A synopsis of the history of data-driven modeling in organic chemistry and the terms used to describe these endeavors is provided and a timeline of the steps that led to its current state is included.

Environmental pollution and global warming cause serious problems in human life. Since the demand for our human daily appliances had been increased by years, the organic chemical-based industries response that demand increment by increasing their production process. Because of that, the environmental pollution becomes worse and worse. Green chemistry thus was introduced to influence the chemical industries to strive for better environmental sustainability. Over 20 years, green chemistry principles have to influence the organic chemistry field especially as many researchers have put their atten...

Metal-organic polyhedra (MOPs) are discrete, intrinsically-porous architectures that operate at the molecular regime and, owing to peripheral reactive sites, exhibit rich surface chemistry. Researchers have recently exploited this reactivity through post-synthetic modification (PSM) to generate specialised molecular platforms that may overcome certain limitations of extended porous materials. Indeed, the combination of modular solubility, orthogonal reactive sites, and accessible cavities yields a highly versatile molecular platform for solution to solid-state applications. In this feature art...

Analysis of the collected data suggests that the use of virtual labs promoted the participants’ motivation to learn organic chemistry as well as ability to integrate concepts taught in the classroom to aspects of their everyday lives.

This study investigated the effect of graphic organizers on conceptual understanding of organic chemistry. The study adopted a mixed-method design involving three intact classes that were purposively selected. A quasi-experimental design and focus group interview was adopted and data was gathered using a chemistry achievement test and an interview protocol whose reliability were 0.74 and 0.73, respectively. The quantitative data were analyzed using analysis of covariance while thematic analysis, with codes generated inductively, was used to analyze the qualitative data. Findings indicated that...

This work investigated whether enantioselectivity data from a reaction can be quantitatively connected to the attributes of reaction components, such as catalyst and substrate structural features, to harness data for asymmetric catalyst design and developed a workflow to relate computationally derived features of Reaction components to enantiOSElectivity using data science tools.

Services and resources recommended for Chemistry Recommended resources for Organic Chemistry

Mechanistic aspects of the isomerization of Z-vinylic tellurides double bonds in the synthesis of potassium Z-vinyltrifluoroborate salts Abstract Through direct transmetalation reaction of Z-vinylic tellurides with nBuLi was observed the unexpected isomerization of double bonds leading to potassium E-vinyltrifluoroborates salts in low to moderate yields. Using EPR spin trapping experiments the radical species that promoted the stereoinversion of Z-vinylic organometallic species during the preparation of potassium vinyltrifluoroborate salts was identified. The experiments support the proposed m...

This new edition represents a major revision; the text has been revised at the sentence level to further improve clarity and readability; many new examples and topics of biological relevance have been added; and many new features have been introduced.

The zwitterionic aza-Claisen rearrangement proved to be an effective and competitive complement to asymmetric electrophilic fluorination strategies and provides access to versatile synthetic intermediates with fluorine at the stereogenic centre.

This review explores the application of AI in areas such as reaction optimization, solvent selection and waste reduction, all key aspects of green chemistry and highlights the potential of AI to accelerate green chemistry innovation while maintaining alignment with the 12 principles of green chemistry.

Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea that it is a mysterious “black box” needs to go. In this review, we show that several of the benefits of microreactor technology can be exploited to push the boundaries in organic synthesis and to unleash unique reactivity and selectivity. By “lifting the veil” on some of the governing principles behind the observed trends, we hope that this review will serve as a useful field guide for those interested in diving into flow chemistry.

в начале 90-х годов ХХ в., ее основные положения непрерывно эволюционировали и развивались. На данный момент насчитывается 10–12 основных "краеугольных камней7quot;, на которых должен быть построен идеальный химический процесс. Данный обзор анализирует накопленный опыт и достижения на пути к созданию химических продуктов и процессов без использования или образования вредных веществ. Обзор представляет точку зрения ведущих российских специалистов, работающих в различных областях данного направления, включая гомогенный и гетерогенный катализ, тонкий и промышленный органический синтез, электрохим...

This review summarized recently developed organic luminescent and photoacoustic materials, ranging from small molecules to conjugated polymers, and elucidated the challenges and prospective of these NIR-II organic dyes for potential clinical applications.

The global pandemic forced educators at all levels to re-evaluate how they would engage content, generate relevance, and assess the development of their students. While alternative grading strategies were not necessarily new to the world of chemical education research (CER) in 2020, the pandemic accelerated the examination of such principles for instructors who wished to prioritize learning over compliance with course policies and eschew points for grading. This article describes the transformation of a traditional lecture organic chemistry course under new, standards-based principles. Working...

This paper examines the current state of the implementation of green chemistry into organic chemistry textbooks. Content analysis of the 15 most used organic chemistry textbooks revealed that only ...

Several aspects of click reactions in organic synthesis, which are highly significant and valuable, are elaborated on in this chapter.

Prerequisites It is very convenient for the student to review the general concepts acquired in the first year subject Fonaments de Química. In particular, the part that refers to chemical and acid-base equilibrium. Minimum knowledge of organic formulation and nomenclature is necessary. Remember that it is a face-to-face subject where part of the assessment will be carried out in class hours (theory and / or problems). For this reason, it is highly recommended not to be enrolled in other subjects that overlap the hours scheduled to this subject.

Prerequisites It is very convenient for the student to review the general concepts acquired in the first year subject Fonaments de Química. In particular, the part that refers to chemical and acid-base equilibrium. Minimum knowledge of organic nomenclature is necessary. Remember that it is a face-to-face subject where part of the assessment will be carried out in class hours (theory and / or problems). For this reason, it is highly recommended not to be enrolled in other subjects that overlap the hours scheduled to this subject.

The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical (in silico) study.

Students perceive organic chemistry as a challenging subject for them to learn and master, which results in a high failure rate. This study investigates the perception of chemistry students of the Department of Chemistry, Kulliyyah of Science at International Islamic University Malaysia (IIUM), on organic chemistry courses and identify the topics that the students found difficult to grasp, which may affect their grades. The correlation of students’ perception on the difficulty level in studying organic chemistry subjects (I and II) with the grades obtained for both courses, and the correlation...

Carbonyl group forms the secondary overlapping with C-2 and C-3 of diene, giving the more stable endo product.

The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical (in silico) study.

It is my view that the unity and consistently critical attitude of Ivy's book make his the more generally useful book of reference.

There is enough on diagnosis and treatment to make the reader a competent dermatologist, and specialists will profit from much of the author's advice, so obviously based on personal experience.

DR. TAYLOR has established a reputation as a writer both of text–books and more popular works on science, end he is thus able to put a little more feeling into his descriptive organic chemistry than is customary—some of the compounds seem to have life and uses and to be something more than colourless crystalline compounds having the formulas indicated. It is a task to get all organic chemistry into 500 pages; the same number of specialized monographs would scarcely do it. Yet something has to be provided to enable the student to beat the examiner. The book has a biological bias as is to–day pr...

It will be found a valuable reference book upon many questions pertaining to economic and commercial aspects of tropical plants, however, the book is often defective, in speaking of the growth of Cannabis sativa for its opium-like drug.

The tropylium ion is a non-benzenoid aromatic species that works as a catalyst. This chemical entity brings about a large number of organic transformations, such as hydroboration reactions, ring contraction, the trapping of enolates, oxidative functionalization, metathesis, insertion, acetalization, and trans-acetalization reactions. The tropylium ion also functions as a coupling reagent in synthetic reactions. This cation’s versatility can be seen in its role in the synthesis of macrocyclic compounds and cage structures. Bearing a charge, the tropylium ion is more prone to nucleophilic/electr...

The fundamental structure of a typical mainstream two-semester organic chemistry course, populated mostly by life science majors and taught at universities throughout the United States, has changed little since the 1970s. However, much of the research on learning in organic chemistry has been devoted to characterizing student difficulties of various types, and there is now persuasive evidence that organic chemistry as currently taught is neither effective nor relevant for a majority of students. In an attempt to address the problems with traditional approaches to organic chemistry instruction,...

It is found that protein sequences containing methionine can be quickly oxidized, providing useful information for protein structure determinations.

Publisher Summary This chapter discusses boranes in organic chemistry, diborane as a reducing agent, volatile compounds of uranium, the alkali metal hydride approach to diborane, and alkali metal borohydrides. The search for solvents led to the discovery of sodium borohydride's being an excellent reducing agent for aldehydes and ketones. The search for catalysts to enhance the reducing power of sodium borohydride led to an anomalous result in the reduction of ethyl oleate. Investigation of this anomalous result led to the discovery of hydroboration. Hydroboration made the organoboranes readily...

Metal–organic frameworks (MOFs) have premium exceptional properties for a variety of functions, such as gas separation and storage and catalysis. The large variety of possible inorganometallic nodes and organic linkers provide an almost unlimited number of combinations for assembling MOFs, which makes the experimental characterization and examination of all potentially useful combinations practically impossible. Furthermore, experimental studies of MOFs typically fall short in uncovering crucial details regarding their mechanisms of action or the molecular details responsible for their functio...

The applications of 2-hydroxy-β-nitrostyrenes as efficient bifunctional intermediates in organic synthesis are investigated in this review. For this purpose, reactions of 2-hydroxy-β-nitrostyrenes with diverse molecules, including carbonyl compounds, 1,3-dicarbonyl compounds, α,β-unsaturated carbonyl compounds, hemiacetals, nitroalkenes, γ-butenolides, tetronic acid, azalactones, pyrazolones, enamines, malononitrile, methyleneindolinones, ylides, etc., were investigated to construct interesting biologically active scaffolds such as chromans, chromenes, coumarins, benzofurans and their fused an...

Abstract The promotion of chemical reactions by an unconventional energy source, mechanical energy (mechanochemistry) has increasing number of applications in organic synthesis. The advantages of mechanochemistry are versatile, from reduction of solvent use, increase of reaction efficiency to better environmental sustainability. This paper gives a short review on the recent developments in the fast growing field of organic mechanochemistry which are illustrated by selected examples.

How efficient industrial organic chemistry can go hand in hand with principles of green chemistry is reflected in this Science Voices article.

This Meeting Review outlines the program for the third annual Empowering Women in Organic Chemistry conference, which gathered organic chemists at all stages of the career pipeline for rich professional development opportunities and a showcase of recent scientific achievements.

To carry out micro-teaching in organic chemistry experiment effectively,green chemistry experimental teaching were realized by changing the types and amounts of chemistry reagent,the process conditions and the use of highly efficient catalyst.Little by-product was produced,which realized the target of waste zero-discharge,and improved the utilization atom.

This short overview describes the historical development of the physics and chemistry of organic solvents and solutions from the alchemist era until the present time based on some carefully selected examples that can be considered landmarks in the history of solution chemistry.