Is there a link between adult neurogenesis and learning?
HippocampusPublished 1 January 2006
Benedetta Leuner, Elizabeth Gould, Tracey J. Shors
Citations526
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SJR score1.31
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TL;DR
This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory.
Abstract
During the past several years, evidence has accumulated suggesting a relationship between newly born cells in the hippocampus and various types of learning and memory. However, most of the evidence is correlational and some of it does not agree. This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory.
Keywords
PsychologyNeuroscience
Journal of Neurology Neurosurgery & PsychiatryLOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
7,274 Citations1957William Beecher Scoville, Brenda Milner
It is concluded that the anterior hippocampus and hippocampal gyrus, either separately or together, are critically concerned in the retention of current experience.
Nature MedicineNeurogenesis in the adult human hippocampus
6,304 Citations1998Peter S. Eriksson, Ekaterina Perfilieva +5 more
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The Journal of Comparative NeurologyAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
3,546 Citations1965Joseph Altman, Gopal D. Das
It is postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated, implicating that they may function as receptors of gonadal hormones.
NatureMore hippocampal neurons in adult mice living in an enriched environment
3,511 Citations1997Gerd Kempermann, H. Georg Kuhn +1 more
It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus.
Journal of NeuroscienceNeurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
3,126 Citations1996H. Georg Kuhn, Heather Dickinson-Anson +1 more
It is confirmed that in the adult rat brain, neuronal progenitor cells divide at the border between the hilus and the granule cell layer (GCL) and in adult rats, the progeny of these cells migrate into the GCL and express the neuronal markers NeuN and calbindin-D28k.
ScienceSynaptic Activity and the Construction of Cortical Circuits
3,067 Citations1996Lawrence C Katz, Carla J. Shatz
The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Proceedings of the National Academy of SciencesRunning enhances neurogenesis, learning, and long-term potentiation in mice
2,894 Citations1999Henriette van Praag, Brian R. Christie +2 more
The results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.
NatureFunctional neurogenesis in the adult hippocampus
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It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.
Annual Review of NeuroscienceSynaptic Plasticity and Memory: An Evaluation of the Hypothesis
2,798 Citations2000Stephen J. Martin, Paul Grimwood +1 more
It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
Nature NeuroscienceLearning enhances adult neurogenesis in the hippocampal formation
2,151 Citations1999Elizabeth Gould, Anna V. Beylin +3 more
It is reported that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus, which indicates that adult- generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
NatureNeurogenesis in the adult is involved in the formation of trace memories
2,019 Citations2001Tracey J. Shors, George R. Miesegaes +4 more
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time.
The Journal of Comparative NeurologyAdult neurogenesis produces a large pool of new granule cells in the dentate gyrus
1,566 Citations2001Heather A. Cameron, Ronald D.G. McKay
A high dose of BrdU (300 mg/kg) is shown to be a specific, quantitative, and nontoxic marker of dividing cells in the adult rat dentate gyrus, whereas lower doses label only a fraction of the S‐phase cells.
ScienceNeurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
1,448 Citations1977Michael Kaplan, James W. Hinds
Three-month-old rats were injected intraperitoneally with [3H]thymidine and labeled cells in the granular layers of dentate gyrus and olfactory bulb were confirmed as neurons by electron microscopy of reembedded 1-micrometer sections.
Proceedings of the National Academy of SciencesProliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
1,386 Citations1998Elizabeth Gould, Patima Tanapat +3 more
The results suggest that neurons are produced in the dentate gyrus of adult monkeys and that the rate of precursor cell proliferation can be affected by a stressful experience.
NatureEnhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
1,292 Citations2004Christoph Schmidt‐Hieber, Péter Jónás +1 more
It is shown that young granule cells in the adult hippocampus differ substantially from mature granules cells in both active and passive membrane properties, contributing to the induction of synaptic plasticity.
Nature MedicineIrradiation induces neural precursor-cell dysfunction
1,255 Citations2002Michelle Monje, Shinichiro Mizumatsu +2 more
It is shown that the deficit in neurogenesis reflects alterations in the microenvironment that regulates progenitor-cell fate, as well as a defect in the proliferative capacity of the neural progenitors in the irradiated hippocampus.
NeuroscienceDifferentiation of newly born neurons and glia in the dentate gyrus of the adult rat
1,210 Citations1993Heather A. Cameron, Catherine S. Woolley +2 more
The majority of newly born cells in the adult dentate gyrus differentiate into neurons, and cells that were immunoreactive for glial fibrillary acidic protein typically showed morphologic characteristics of radial glia at all time-points.
NatureStress and glucocorticoids impair retrieval of long-term spatial memory
1,190 Citations1998Dominique J.‐F. de Quervain, Benno Roozendaal +1 more
It is shown that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2’min or 4 h before testing, which suggests that the retention impairment is directly related to increased adrenocortical function.
Proceedings of the National Academy of SciencesPrenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
1,035 Citations2000Valérie Lemaire, Muriel Koehl +2 more
It is reported that prenatal stress in rats induced lifespan reduction of neurogenesis in the dentate gyrus and produced impairment in hippocampal-related spatial tasks and pathophysiological hypotheses that propose an early neurodevelopmental origin for psychopathological vulnerabilities in aging are strengthened.
Nature reviews. NeuroscienceStructural plasticity and memory
1,022 Citations2004Raphael Lamprecht, Joseph E. LeDoux
Rapid changes in cytoskeletal and adhesion molecules after learning contribute to short-term plasticity and memory, whereas later changes, which depend on de novo protein synthesis as well as the early modifications, seem to be required for the persistence of long-term memory.
Proceedings of the National Academy of SciencesNeuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain.
983 Citations1983Steven A. Goldman, Fernando Nottebohm
It is concluded that neuronal precursors exist in the HVc ventricular zone that incorporate tritiated thymidine during the S phase preceding their mitosis; after division these cells migrate into, and to some extent beyond, HVm, which seems to be a normally occurring phenomenon in intact adult female canaries.
Journal of NeuroscienceEstrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female Rat
975 Citations1999Patima Tanapat, Nicholas B. Hastings +2 more
It is suggested that estrogen-enhanced cell proliferation during proestrus results in more immature neurons in the hippocampal formation of females compared with males and present the possibility that these new cells exert an important influence on hippocampal function.
Journal of AnatomyFunctional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
892 Citations2005Morris Moscovitch, R. Shayna Rosenbaum +9 more
The evidence suggests strongly that the function of the hippocampus (and possibly that of related limbic structures) is to help encode, retain, and retrieve experiences, no matter how long ago the events comprising the experience occurred, and no matter whether the memories are episodic or spatial.
HippocampusNeurogenesis may relate to some but not all types of hippocampal‐dependent learning
846 Citations2002Tracey J. Shors, David A. Townsend +3 more
The results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal‐dependent memories.
NeuroscienceA role for adult neurogenesis in spatial long-term memory
840 Citations2004Jason S. Snyder, N.S. Hong +2 more
It is shown that new neurons aged 4-28 days old at the time of training are required for long-term memory in a spatial version of the water maze, suggesting a new role for adult neurogenesis in the formation and/or consolidation of long- term, hippocampus-dependent, spatial memories.
Proceedings of the National Academy of SciencesHippocampal neurogenesis in adult Old World primates
806 Citations1999Elizabeth Gould, Alison J. Reeves +4 more
Results indicate that the adult brains of Old World monkeys produce new hippocampal neurons, and adult macaque monkeys may provide a useful primate model for studying the functional significance of adult neurogenesis.
Nature reviews. NeuroscienceNeurogenesis in the adult brain: death of a dogma
798 Citations2000Charles G. Gross
This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse as a central assumption in the field of neuroscience.
Brain ResearchRepeated stress causes reversible impairments of spatial memory performance
757 Citations1994Victoria N. Luine, Miriam Villegas +2 more
These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.
Experimental NeurologyRadiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
704 Citations2004Radosław Rola, Jacob Raber +5 more
Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
Radiation ResearchRadiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis
696 Citations2004Jacob Raber, Radosław Rola +6 more
It is shown that the Barnes maze is particularly sensitive for the detection of radiation-induced cognitive deficits in young adult mice and the significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation -induced cognitive impairments.
NeuronExcitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells
668 Citations2004Karl Deisseroth, Sheela Singla +4 more
It is demonstrated that excitatory stimuli act directly on adult hippocampal NPCs to favor neuron production and, when applied as an "excitation-neurogenesis coupling rule", predict significant advantages for both the temporary storage and the clearance of memories.
Proceedings of the National Academy of SciencesSpatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis
648 Citations2003Elodie Drapeau, Willy Mayo +4 more
The extent of memory dysfunction in aged rats is quantitatively related to the hippocampal neurogenesis and these data reinforce the assumption that neuroGenesis is involved in memory processes and aged-related cognitive alterations.
Journal of NeurophysiologyEffects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus
635 Citations2001Jason S. Snyder, Nohjin Kee +1 more
It is concluded that the young, adult-generated granule neurons play a significant role in synaptic plasticity in the DG, the major source of the afferent inputs into the hippocampus.
Nature NeuroscienceEarly life experience alters response of adult neurogenesis to stress
628 Citations2004Christian Mirescu, Jennifer D. Peters +1 more
The results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood.
The Journal of Comparative NeurologyShort‐term and long‐term survival of new neurons in the rat dentate gyrus
628 Citations2003Alexandre Dayer, Abigail Ford +3 more
It is suggested that granule cells born during adulthood that become integrated into circuits and survive to maturity are very stable and may permanently replace granule Cells born during development.
Proceedings of the National Academy of SciencesOpiates inhibit neurogenesis in the adult rat hippocampus
601 Citations2000Amelia J. Eisch, Michel Barrot +3 more
The findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.
The Journal of Comparative NeurologyRapid extension of axons into the CA3 region by adult-generated granule cells
595 Citations1999Nicholas B. Hastings, Elizabeth Gould
It is reported that immature granule cells extend axons into CA3 as rapidly as 4–10 days after mitosis, and results suggest that adult‐generated granule neurons may influence normal hippocampal function, even at a very early stage after their production.
The Journal of Comparative NeurologyAdult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles
564 Citations1999Eleni A. Markakis, Fred H. Gage
It is concluded that newly generated neurons in the dentate gyrus have the correct immunohistochemical profile, send appropriate axonal projections to field CA3, and are surrounded by profiles containing synaptic vesicle proteins.
European Journal of NeuroscienceNew neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment
499 Citations2005Elodie Bruel‐Jungerman, Serge Laroche +1 more
It is established that newborn cells in the dentate gyrus contribute to the expression of the promnesic effects of behavioural enrichment, and they provide further support for the idea that adult‐generated neurons participate in modulating memory function.
Proceedings of the National Academy of SciencesSeasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees.
492 Citations1994Anat Barnea, Fernando Nottebohm
It is suggested that the neurons added are part of a process of neuronal replacement and that they are important for the acquisition of new spatial memories, a need that is particularly acute in the fall.
NeuroscienceArrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
491 Citations2003Torsten Madsén, Paul E.G. Kristjansen +2 more
Journal of NeurochemistryBinge ethanol exposure decreases neurogenesis in adult rat hippocampus
483 Citations2002Kimberly Nixon, Fulton T. Crews
These studies are the first to show EtOH inhibition of neural progenitor cell proliferation and survival in the adult, a possible new mechanism underlying alcoholic cognitive dysfunction.
Journal of NeuroscienceWhy New Neurons? Possible Functions for Adult Hippocampal Neurogenesis
467 Citations2002Gerd Kempermann
The dentate gyrus of the adult hippocampal formation generates neurons throughout life, but it remains unclear why and how these neurons are used.
Behavioral NeuroscienceHippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.
445 Citations1995Jeansok J. Kim, Robert E. Clark +1 more
The hippocampus appears to be necessary for the retention of recently acquired, but not remotely acquired, trace conditioned responses in rabbits.
Hormones and BehaviorEstradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters
445 Citations1998Victoria N. Luine, Shannon T. Richards +2 more
Results show that estrogen enhances learning/memory on a task utilizing spatial memory and appears to require the chronic (several days) presence of estrogen.
Trends in Cognitive SciencesNeurogenesis in adulthood: a possible role in learning
425 Citations1999Elizabeth Gould
Several lines of evidence suggesting that adult-generated neurons are involved in hippocampal-dependent learning are examined, including the variables that modulate hippocampal neurogenesis in adulthood and their relation to learning and memory.
Journal of NeurobiologyHeterogenous properties of dentate granule neurons in the adult rat
416 Citations2000Sabrina Wang, Brian W. Scott +1 more
It is proposed that the heterogeneity of the functional properties of the granule neurons is related to the ongoing neurogenesis in the adult animals.
HippocampusHippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat
393 Citations1999Matthew D. McEchron, Hans Bouwmeester +3 more
The present study sought to determine whether the hippocampus was necessary for rats to perform a classical trace fear conditioning task in which each of 10 trials consisted of an auditory tone CS followed by an empty 30‐s trace interval and then aFear producing floor‐shock US.
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388 Citations1999David M. Diamond, Collin R. Park +2 more
The findings indicate that the capacity for stress to impair memory is influenced not only by the brain memory system involved in solving the task (hippocampal versus nonhipp hippocampus), but also by the difficulty of the task.
Brain ResearchNeonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats
382 Citations2002Rebecca L. Huot, Paul M. Plotsky +2 more
The results suggest that repeated, daily, 3-h maternal separations during critical periods of hippocampal development can disrupt hippocampal cytoarchitecture in a stable manner.
The Journal of Comparative NeurologyExposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone‐dependent mechanism
369 Citations2001Patima Tanapat, Nicholas B. Hastings +3 more
It is suggested that stressful experiences rapidly diminish cell proliferation by increasing adrenal hormone levels, resulting in a transient decrease in the number of adult‐generated immature granule neurons.
Hormones and BehaviorEstrogen Enhances Performance of Female Rats during Acquisition of a Radial Arm Maze
357 Citations1997Jill M. Daniel, Aric J. Fader +2 more
The positive effect of estradiol exposure prior to training suggests that estrogen may induce neuronal changes that persist beyond the period of exposure with functional consequences for behavior.
Journal of NeuroscienceTime-Dependent Reorganization of the Brain Components Underlying Memory Retention in Trace Eyeblink Conditioning
337 Citations2003Kaori Takehara‐Nishiuchi, Shigenori Kawahara +1 more
The results indicate that the hippocampus and the cerebellum, but only marginally the mPFC, constitute a brain circuitry that mediates recently acquired memory.
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329 Citations1997Matthew L. Shapiro, Heikki Tanila +1 more
The results show that hippocampal neurons encode a hierarchical representation of environmental information through the encoding of local and distal cues within a stimulus set.
European Journal of NeuroscienceGenetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task
294 Citations2002Gerd Kempermann, Fred H. Gage
There was a significant correlation between the number of new neurons generated in the dentate gyrus and parameters describing the acquisition of the water maze task (slope of the learning curves), and this result supports the hypothesis that adult neurogenesis is involved in specific aspects of hippocampal function, particularly the Acquisition of new information.
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291 Citations2002Marie Carlén, Robert M. Cassidy +4 more
Virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity are used to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
Journal of NeuroscienceLearning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory
281 Citations2004Bendetta Leuner, Sabrina Mendolia‐Loffredo +4 more
The data suggest that individual differences in associative learning predict whether new neurons will survive and that once affected, these neurons remain for months and beyond the time when they are required for the retention of trace memories.
ScienceBirth of Projection Neurons in Adult Avian Brain May Be Related to Perceptual or Motor Learning
278 Citations1990Arturo Álvarez-Buylla, John R. Kirn +1 more
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251 Citations2005Suzanna Becker
Simulations of the complete circuit confirm that both recognition memory and recall are superior relative to a hippocampally lesioned model, consistent with human data and support the prediction that memory capacity increases with the number of dentate granule cells, while neuronal turnover with a fixed dentate layer size improves recall.
Molecular PsychiatryDifferential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date
247 Citations2003Máté D. Döbrössy, Elodie Drapeau +4 more
It is demonstrated that the late phase of learning has a multifaceted effect on neurogenesis depending on the birth date of new neurons, and a novel mechanism through which neuroGenesis may influence normal and pathological behaviors is revealed.
Neurobiology of Learning and MemoryThe Role of the Hippocampus in Trace Conditioning: Temporal Discontinuity or Task Difficulty?
244 Citations2001Anna V. Beylin, Chetan C. Gandhi +4 more
The role of the hippocampus in classical conditioning is not limited to learning about discontiguous events in time and space; rather the structure can become engaged simply as a function of task difficulty.
Journal of NeuroscienceNicotine Self-Administration Impairs Hippocampal Plasticity
221 Citations2002Djoher Nora Abrous, Walter Adriani +5 more
It was found that nicotine self-administration profoundly decreased, in a dose-dependent manner, the expression of PSA-NCAM in the dentate gyrus of the hippocampal formation of animals trained to self-administer nicotine.
Brain ResearchMorpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus
218 Citations2004Patrizia Ambrogini, Davide Lattanzi +6 more
In this study electrophysiological and morphological features of granule layer cells, characterized as immature or mature neurons, without and with synaptic input, were comparatively described in adult rats.
Journal of NeurophysiologySleep Restriction Suppresses Neurogenesis Induced by Hippocampus-Dependent Learning
217 Citations2005Ilana S. Hairston, Milton T. M. Little +5 more
It is suggested that sleep loss altered behavioral strategies to those that do not depend on the hippocampus, concomitantly reversing the neurogenic effects of hippocampus-dependent learning.
Proceedings of the National Academy of SciencesCell death and neuronal recruitment in the high vocal center of adult male canaries are temporally related to changes in song.
207 Citations1994John R. Kirn, B O'Loughlin +2 more
It is suggested that seasonal peaks in cell loss and neuronal recruitment in HVC are related to endocrine changes and that all three play a role in the seasonality of song modification.
Neuroscience LettersSpatial learning affects immature granule cell survival in adult rat dentate gyrus
205 Citations2000Patrizia Ambrogini, Riccardo Cuppini +6 more
The survival of newborn cells was enhanced by learning at early stage of differentiation; the newborn cells saved by learning were mainly located in the rostral part of external blade of granule cell layer and there was a correlation between the actual individual learning and newborn cell survival.
European Journal of NeuroscienceProduction of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline
199 Citations2003Jennifer L. Bizon, Michela Gallagher
The current investigation used a model of age‐related cognitive decline in rodents to study the relationship between changes in markers of neurogenesis and hippocampal function and found that the pronounced decrease in new cell production during aging did not distinguish among rats that varied over a wide range of cognitive abilities.
Behavioral NeuroscienceThe contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning males versus females.
197 Citations2001Gwendolyn E. Wood, Anna V. Beylin +1 more
Learning & MemoryA Facilitative Role for Corticosterone in the Acquisition of a Spatial Task Under Moderate Stress
169 Citations2004Irit Akirav, Maya Kozenicky +4 more
It is found that whereas animals injected with vehicle performed well in the spatial task in cold water (moderate stress), rats injected with the intermediate metyrapone dose showed impairment in performance, which strongly suggest that corticosterone is instrumental in the acquisition and retention of the spatial learning task.
Trends in NeurosciencesMemory traces of trace memories: neurogenesis, synaptogenesis and awareness
167 Citations2004Tracey J. Shors
This work has shown that the hippocampus is crucial for the initial acquisition of trace memories but not for their expression or long-term storage, and implicate neurogenesis, synaptogenesis and awareness in the formation of trace Memories.
Behavioral NeuroscienceLow levels of estradiol facilitate, whereas high levels of estradiol impair, working memory performance on the radial arm maze.
166 Citations2002Melissa M. Holmes, Jennifer K. Wide +1 more
Taken together, these data demonstrate a dose-dependent effect of EB on working memory, and demonstrate that estradiol benzoate's effects on learning and memory yielded equivocal results.
NeuropsychopharmacologySimulated Apoptosis/Neurogenesis Regulates Learning and Memory Capabilities of Adaptive Neural Networks
164 Citations2003R. Andrew Chambers, Marc N. Potenza +2 more
These simulations predict that apoptotic and neurogenic events could act together to produce specific learning and memory effects beyond those provided by ongoing mechanisms of connection plasticity in neuronal populations.
European Journal of NeuroscienceBehavioural trait of reactivity to novelty is related to hippocampal neurogenesis
148 Citations1999Valérie Lemaire, C. Aurousseau +2 more
The results demonstrate the existence of inter‐individual differences in neurogenesis and total granule cell number within the dentate gyrus, which can be predicted by the behavioural trait of reactivity to novelty.
Proceedings of the National Academy of SciencesRecruitment and replacement of hippocampal neurons in young and adult chickadees: an addition to the theory of hippocampal learning.
142 Citations1996Anat Barnea, Fernando Nottebohm
It is speculated that juveniles encounter greater environmental novelty than adults and that the greater number of HC neurons found in juveniles allows them to learn more than adults.
Current Opinion in NeurologyAny novelty in hippocampal formation and memory?
133 Citations2005Lars Nyberg
Interindividual variability in the responsiveness of the hippocampal-novelty system may be genetically mediated, and personality factors can also play a role, which can have implications for interventions aimed at supporting memory and for the treatment of drug abuse.
Behavioural Brain ResearchIncreased responsivity of dentate granule cells during nictitating membrane response conditioning in rabbit
131 Citations1984Donald J. Weisz, Gregory A. Clark +1 more
Preliminary evidence is provided that processes similar to long-term potentiation may occur in the hippocampus during behavioral conditioning during classical conditioning of the rabbit nictitating membrane response.
Nature MethodsStem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination
127 Citations2005Christopher J. Vega, Daniel A. Peterson
PsychopharmacologyChronic opioids impair acquisition of both radial maze and Y-maze choice escape
116 Citations1991James Spain, Gordon C. Newsom
In the Y-maze choice escape task, acquisition of a response strategy was significantly impaired in rats that had been previously treated with morphine for 17–21 days, despite clear indications that morphine-treated rats were sensitive to the aversive stimulus.
Nature New BiologyBehavioural Effects of Interference with the Postnatal Acquisition of Hippocampal Granule Cells
112 Citations1973Shirley A. Bayer, Robert L. Brunner +2 more
Irradiation of the infant rat hippocampus using a schedule derived from previous cerebellar autoradiographic and irradiation studies should reduce the population of granule cells without directly harming the prenatally-formed pyramidal cells of Amnion's horn.
Neuroscience LettersLearning may reduce neurogenesis in adult rat dentate gyrus
110 Citations2004Patrizia Ambrogini, Laura Orsini +4 more
A different effect of learning on immature neuron survival, depending on the time elapsing from mitosis to learning, is suggested.
PsychoneuroendocrinologyHigh levels of estrogen enhance associative memory formation in ovariectomized females
102 Citations2003Benedetta Leuner, Sabrina Mendolia‐Loffredo +1 more
The results provide additional support to the view that that ovarian steroids are beneficial to the performance of certain forms of learning and memory tasks, albeit at supraphysiological doses.
European Journal of NeuroscienceSHORT COMMUNICATION Selective enhancement of spatial learning under chronic psychosocial stress
95 Citations2002Alessandro Bartolomucci, Gabriel de Biurrun +3 more
It is shown that chronic stress enhanced learning in animals performing the hippocampal‐dependent task, whereas no stress‐induced effect was found in the hippocampa‐independent task, and after five weeks of stress, cell proliferation was reduced in the hippocampusal dentate gyrus.
Biological PsychiatryMales and females respond differently to controllability and antidepressant treatment
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These data indicate that males and females not only respond in opposite directions to the same stressful event but also respond differently to controllability and antidepressant treatments.
HippocampusA natural form of learning can increase and decrease the survival of new neurons in the dentate gyrus
86 Citations2005Ana Olariu, Kathryn M. Cleaver +3 more
It is proposed that training may initially increase young granule cell survival, then, if continued, cause them to die, which could potentially serve to maintain granule cells that are actively involved in memory consolidation, while rapidly using and discarding young granules cells whose training is complete to make space for new naïve neurons.
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84 Citations2004K Pham, Bruce S. McEwen +2 more
The effect of context conditioning on cell proliferation appears to be specifically due to the formation of an association between the context and shock during training, an amygdala dependent function.
Behavioral NeuroscienceMorris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis.
78 Citations2005Karin van der Borght, Alinde E. Wallinga +3 more
It is demonstrated that Morris water maze learning causes plastic change in the dentate gyrus without affecting hippocampal neurogenesis.
European Journal of NeuroscienceMethylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus
72 Citations2005David Dupret, Marie‐Françoise Montaron +5 more
The behavioural results obtained following subchronic treatment with high doses of MAM in adulthood must be interpreted with extreme caution because of the small residual number of new cells produced following MAM treatment.
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64 Citations2004Douglas B. Matthews, Janelle R. Silvers
It is concluded that acute ethanol administration is a valuable tool in studying hippocampal function and multiple memory systems.
PsychopharmacologyThe effects of chronic nicotine on spatial learning and bromodeoxyuridine incorporation into the dentate gyrus of the rat
61 Citations2005Charles Scerri, Caroline A. Stewart +2 more
The data suggest that learning in the water maze task is impaired by higher doses of nicotine tested, and that this response may be related to reduced cell genesis in the DG.
Behavioural Brain ResearchEffects of active shock avoidance learning on hippocampal neurogenesis and plasma levels of corticosterone
59 Citations2004Karin van der Borght, Peter Meerlo +3 more
The present study shows that, in line with the existing data on other hippocampus-independent learning tasks, ASA training has no effect on hippocampal neurogenesis.
Proceedings of the National Academy of SciencesReplaceable neurons and neurodegenerative disease share depressed <i>UCHL1</i> levels
48 Citations2005Anthony J. Lombardino, XiaoChing Li +2 more
The high vocal center of male zebra finches and the mouse brain found relatively low UCHL1 expression in granule neurons of the hippocampus and olfactory bulb, two well characterized types of replaceable neurons in mammals.
Neuroscience LettersCorrelation between threshold to induce long-term potentiation in the hippocampus and performance in a shuttle box avoidance response in rats
35 Citations1989Oscar A. Ramírez, Hugo F. Carrer
It is concluded that learning ability of normal rats in a shuttle box avoidance paradigm is correlated with hippocampal synaptic plasticity.
Journal of Comparative and Physiological PsychologyEarly postnatal X-irradiation of the hippocampus and discrimination learning in adult rats.
34 Citations1981Russell A. Gazzara, Joseph Altman
The results suggest that the irradiated rats were not handicapped when the noticeability of the stimuli was high, irrespective of modality used, but were handicapped in the acquisition and reversal phases of the task.
PsychopharmacologyEffect of chronic cold stress on catecholamine levels in rat brain
19 Citations1969B. Bhagat
It seems that repeated exposure to cold may have induced adaptive changes in physiologic system resulting in acceleration of brain norepinephrine turnover.
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