Host factors and the pathogenesis of HIV-induced disease
NaturePublished 1 December 1996
A S Fauci
Citations846
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The level of human immunodeficiency virus replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines); new information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance understanding of HIV-induced pathogenesis.
Abstract
The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.
Keywords
Immunology and MicrobiologyMedicine
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142 Citations1995WA O'Brien, Kathie Grovit‐Ferbas +7 more
The Journal of ImmunologyBeta-chemokine inhibition of monocytotropic HIV-1 infection. Interference with a postbinding fusion step
131 Citations1996Tamás Oravecz, Marina Pall +1 more
The data support a role for a RANTES chemokine receptor as a coreceptor for monocytotropic-HIV-1 and a reversible competitive mechanism of virus inhibition that prevents a V3-associated postbinding step in membrane fusion.
Proceedings of the National Academy of SciencesHIV replication in CD4 <sup>+</sup> T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines
124 Citations1996Audrey Kinter, Mario Ostrowski +8 more
The data suggest that the levels of HIV replication in CD4+ PBMC reflect the balance of the opposing effects of endogenous suppressive factors, such as the beta-chemokines, and HIV-inducing cytokines,such as tumor necrosis factor alpha and interleukin 1 beta.
Journal of VirologyDual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates
102 Citations1994Antonio Valentin, Jan Albert +2 more
The ability of HIV isolates to replicate in monocytes/macrophages appears to be strongly influenced by the isolation and culture procedures, although it remains to be determined which culture procedure is more relevant for the in vivo situation.
Journal of VirologyIsolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo
96 Citations1995Riri Shibata, M D Hoggan +8 more
HIV-1DH12 tissue culture infections were characterized by extremely rapid replication kinetics, profound cytopathicity, and tropism for chimp and human PBMC, primary human macrophage, and several human T-cell lines.
Annals of Internal MedicinePlasma Cytokines, Cytokine Antagonists, and Disease Progression in African Women Infected with HIV-1
78 Citations1996Donald M. Thea, Reuven Porat +6 more
The data suggest the clinical importance of cytokine antagonists in modulating symptoms during the early stages of HIV-1 infection, and a cross-sectional comparison of plasma cytokine levels is done.
Clinical Infectious DiseasesNonhuman Primate Models for AIDS
67 Citations1993Patricia N. Fultz
The SIV macaque model has proven valuable in all aspects of AIDS-related research, with primary emphasis on defining pathogenic properties of lentiretroviruses and on testing novel approaches for prophylactic and therapeutic intervention.
AIDSLower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men
58 Citations1995Ingrid J. B. Spijkerman, Maarten Koot +5 more
The remarkable lower prevalence and incidence of the SI phenotype among IDU may implicate a difference in pathogenesis and natural history of HIV infection linked to transmission group and be consistent with the hypothesis that the effect of SI phenotype on progression to AIDS is mediated by CD4 cell count.
The Journal of ImmunologyIdentification of multiple and distinct CD8+ T cell suppressor activities: dichotomy between infected and uninfected individuals, evolution with progression of disease, and sensitivity to γ irradiation
51 Citations1996Tobias Barker, Drew Weissman +3 more
The results indicate that CD8+ T cell modulation of HIV replication in CD4+ T cells is a multifactorial phenomenon involving both inhibitory and stimulatory effects on HIV replication.
Clinical & Experimental Immunology<i>Mycobacterium avium</i>infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens
40 Citations1994M. Denis, E Ghadirian
Assessment of viral burden in cells of HIV‐1‐ Infected subjects revealed that Myco.
AIDSTransition dynamics of HIV disease in a cohort of African prostitutes
34 Citations1990Nico Nagelkerke, Francis A. Plummer +5 more
It appears that the progression to symptomatic disease in this population of African prostitutes is considerably more rapid than that reported from studies in Western countries.
Advances in experimental medicine and biologyAids as Immune System Activation
34 Citations1995Michael S. Ascher, Haynes W. Sheppard +2 more
This line of thinking represents a significant shift in the paradigm away from considering HIV disease like any other cytopathic viral infection, and will bring to the fore some of the central unanswered questions in modern cellular immunology.
AIDSEarly diagnosis of vertically acquired HIV-1 infection
30 Citations1991Gareth Tudor‐Williams
In this issue of the journal, de Rossi and her colleagues present data on 101 infants studied prospectively to at least 18 months comparing the three methods and detection of HIV p24 antigen.
American Review of Respiratory DiseaseHuman Immunodeficiency Virus Production by Alveolar Lymphocytes Is Increased during <i>Pneumocystis carinii</i> Pneumonia
28 Citations1993Dominique Israël‐Biet, J Cadranel +1 more
It is shown that HIV core p24 antigen production by enriched alveolar and blood lymphocytes is strongly related to the presence or absence of PC, and increased viral production is compartmentalized to the affected organ.
AIDSTransient elevation of serum HIV antigen levels associated with intercurrent infection
26 Citations1991E. Claydon, John M. Bennett +2 more
Little has been reported about an individual's day to day variations in antigen levels, or of the factors that may influence the degree of antigenaemia.
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