Sleep spindle characteristics in healthy subjects of different age groups
Clinical NeurophysiologyPublished 1 March 2001
A. Nicolas, Dominique Petit, Sylvie Rompré, Jacques Montplaisir
Citations208
SJR quartileQ1
SJR score1.33
SNIP1.38
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The progressive decrease in the number of SS and slow-wave sleep time with age suggests that SS are part of sleep promoting mechanisms, and the negative correlation found between SS density and sleep efficiency in the present study is congruent with the sleep maintenance role of SS.
Abstract
The progressive decrease in the number of SS and slow-wave sleep time with age suggests that SS are part of sleep promoting mechanisms. The negative correlation found between SS density and sleep efficiency in the present study is congruent with the sleep maintenance role of SS.
Keywords
PsychologyMedicineNeuroscience
Elsevier eBooksPrinciples and Practice of Sleep Medicine
5,133 Citations2011Meir H. Kryger, Thomas Roth +1 more
European Archives of Psychiatry and Clinical NeuroscienceÜber das Elektrenkephalogramm des Menschen
4,124 Citations1929Hans Berger
ScienceThalamocortical Oscillations in the Sleeping and Aroused Brain
3,602 Citations1993Mircea Steriade, David A. McCormick +1 more
Analysis of cortical and thalamic networks at many levels, from molecules to single neurons to large neuronal assemblies, with a variety of techniques, is beginning to yield insights into the mechanisms of the generation, modulation, and function of brain oscillations.
Journal of NeurophysiologyThe deafferented reticular thalamic nucleus generates spindle rhythmicity
640 Citations1987Mircea Steriade, L Domich +2 more
The preservation of both spindle-related rhythms in the disconnected RE nucleus, together with the recent experiments showing abolition of spindle oscillations in thalamic nuclei after lesions of RE nucleus demonstrate that RE nucleus is the generator of spindling rhythms.
NeuroscienceLow-frequency (<1Hz) oscillations in the human sleep electroencephalogram
587 Citations1997Peter Achermann, Alexander A. Borbély
The results demonstrate that distinct components below 1 Hz are also present in the human sleep electroencephalogram spectrum, in accordance with results from animal experiments.
Journal of Psychiatric ResearchEEG sleep patterns as a function of normal and pathological aging in man
457 Citations1967Irwin Feinberg, Richard L. Koresko +1 more
It appears that the EEG of sleep may prove to be a diagnostic and research tool of special value to geriatric psychiatry because the quantitative changes in sleep with normal and pathological aging are similar to changes which take place in rate of overall brain metabolism.
Journal of the American Geriatrics SocietyChanges in the Sleep and Waking EEGs of Nondemented and Demented Elderly Subjects
368 Citations1982Patricia N. Prinz, Elaine R. Peskind +5 more
Monitoring of sleep and waking EEGs from healthy nondemented elderly men and inpatients for whom the diagnosis was probable senile dementia of Alzheimer's type suggested that correlative neuropathologic data might provide an understanding of the basis for the sleep, EEG, and mental‐function factors that undergo change in SDAT.
Brain ResearchEffect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men
347 Citations1996Hans‐Peter Landolt, Derk‐Jan Dijk +2 more
It is concluded that frequency and state specific changes occur as a function of age, and that sleep dependent decline in SWA and increase in sleep spindle activity are attenuated with age.
Mayo Clinic ProceedingsPrinciples and Practice of Sleep Medicine
343 Citations1990Philip R. Westbrook
American Journal of Physiology-Endocrinology and MetabolismNeuroendocrine rhythms and sleep in aging men
334 Citations1991A. Van Coevorden, Jean Mockel +6 more
It is demonstrated that the normal process of aging involves alterations in the central mechanisms controlling the temporal organization of endocrine release in addition to a reduction of secretory outputs.
The Journal of PhysiologySpindle oscillation in cats: the role of corticothalamic feedback in a thalamically generated rhythm.
333 Citations1996Diego Contreras, Mircea Steriade
Brain ResearchDynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation
315 Citations1993Derk‐Jan Dijk, Boyd Hayes +1 more
These data demonstrate that when averaged per sleep episode or non-REM sleep episode an inverse relationship between SWA and spindle activity exists but that in the initial and final part of non-Rapid-eye-movement sleep episodes the association between these two activities is positive.
Electroencephalography and Clinical NeurophysiologySpindle frequency activity in the sleep EEG: individual differences and topographical distribution
264 Citations1997Esther Werth, Peter Achermann +2 more
The functional and topographic heterogeneity of sleep spindles in conjunction with the intra-subject stability of their frequency are important characteristics for the analysis of sleep regulation on the basis of the EEG.
Journal of Sleep ResearchTopographic distribution of sleep spindles in young healthy subjects
225 Citations1997J. Zeitlhofer, G. Gruber +4 more
The application of an automatic sleep spindle detection procedure allowed the documentation of the topographic distribution of spindle characteristics, such as number, amplitude, frequency and duration, as a function of sleep depth and of recording time.
Biological PsychiatryEEG sleep in elderly depressed, demented, and healthy subjects
217 Citations1985Charles F. Reynolds, David J. Kupfer +9 more
In a prospective study of EEG sleep patterns in 25 elderly depressives, 25 elderly demented patients, and 25 healthy, elderly control subjects, the sleep of depressives was characterized by reduced REM sleep latency, increased REM percent and first REM period density, and altered temporal distribution of REM sleep, as well as by diminished sleep maintenance.
SLEEPSleep in Alzheimer's Disease: Further Considerations on the Role of Brainstem and Forebrain Cholinergic Populations in Sleep-Wake Mechanisms
153 Citations1995Jacques Montplaisir, Dominique Petit +3 more
NeuropsychobiologyTopographical Analysis of Sleep Spindle Activity
151 Citations2008Marc Jobert, Éric Poiseau +3 more
The existence of two distinct sources of activity located in the frontal and parietal region of the brain, respectively, was demonstrated using EEG frequency mapping and pharmacological effects of lormetazepam and zopiclone were investigated.
SLEEPSpindle Density in Sleep of Normal Subjects
145 Citations1981J.-M. Gaillard, R. Blois
Results indicated that spindle density was the same in stages 2, 3, and 4, and was much lower in rapid eye movement (REM) sleep, while K potentials were less abundant than spindles and exhibited a much smaller individual variability.
Neuroscience LettersMelatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity
135 Citations1995Derk‐Jan Dijk, Corinne Roth +5 more
Changes in the EEG are to some extent similar to those induced by benzodiazepine hypnotics and to the contribution of the endogenous circadian pacemaker to the spectral composition of the sleep EEG when sleep occurs at night.
Neuroscience LettersAttenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects
127 Citations1999Henry Wei, Eymard Riel +2 more
It is demonstrated that a circadian process modulates sleep spindle characteristics and that the strength of this circadian modulation is reduced with age.
Brain Research BulletinSigma (12–15 Hz) and Delta (0.3–3 Hz) EEG oscillate reciprocally within NREM sleep
126 Citations1991Sunao Uchida, Thomas Maloney +3 more
Results show that cyclic oscillation of EEG within sleep is not limited to delta frequencies, and the reciprocal relation of sigma to delta holds implications for the EEG mechanisms of NREM sleep.
Electroencephalography and Clinical NeurophysiologyDifferences in sleep in patients with parkinson's disease
116 Citations1975J Mouret
The study of signs showed that association between blinking and persistence of the activity of the chin muscles during paradoxical sleep is never encountered, and the possibility that lesions of the locus coeruleus are responsible for this decrease in paradoxicalSleep is discussed.
Behavioural Brain ResearchEEG slow waves and sleep spindles: windows on the sleeping brain
113 Citations1995Derk‐Jan Dijk
The precise regulation of slow-wave and spindle activity as a function of the duration and intensity of prior sleep and wakefulness demonstrates that these EEG oscillations are accurate indicators of non-REM-sleep homeostasis and suggests that they are fundamental to the sleeping brain.
Electroencephalography and Clinical NeurophysiologySleep spindles in normal elderly: comparison with young adult patterns and relation to nocturnal awakening, cognitive function and brain atrophy
105 Citations1986M. Guazzelli, Irwin Feinberg +4 more
The amount of waking in the elderly was not inversely correlated with spindle abundance, confirming earlier observations but in a much larger group, and a linear increase in spindle density and duration across NREMPs in young adults was demonstrated, indicating that age affects the temporal pattern as well as the quantity of spindles.
NeurologySleep and quantitative EEG in patients with progressive supranuclear palsy
100 Citations1997Jacques Montplaisir, Dominique Petit +6 more
The present finding of EEG slowing in the frontal lobes (rather than in the temporal regions or diffusely) suggests that the quantitative EEG approach may be more useful in determining specific regions of impaired cortical activity.
Electroencephalography and Clinical NeurophysiologySleep-wake cycle abnormalities in fatal familial insomnia. Evidence of the role of the thalamus in sleep regulation
96 Citations1995E. Sforza, P. Montagna +7 more
Alterations in sleep organization were longitudinally studied in 6 new cases of fatal familial insomnia and confirm that impairment of sleep-wake regulation is a consistent distinctive feature of FFI.
SLEEPDynamic Relation of Sleep Spindles and K-Complexes to Spontaneous Phasic Arousal in Sleeping Human Subjects
77 Citations1982Paul Naitoh, Violaine Antony-Baas +2 more
A working hypothesis was formulated to interpret a triad of sleep events: sleep spindles, K0-complexes, and slow wave sleep and three kinds of sleep are suggested as more useful classifications than the Rechtschaffen and Kales categories.
SLEEPSleep Spindle Characteristics as a Function of Age
70 Citations1982C. Principe Jose, R. Smith Jack
The characteristics of sleep spindles as a function of age were studied with an automated analysis system and significant differences in spindle frequency were found between groups 0-I and II-III-IV.
SLEEPK-Complexes and Sleep Spindles Before Transient Activation During Sleep
61 Citations1981J. Ehrhart, M Ehrhart +3 more
The results suggest that spontaneous K-complexes and sleep spindles act antagonistically with respect to the occurrence of PATs, and these two phasic events are significantly related to regulating the probability of occurring PATs in sleep stages 2 and 3.
SLEEPRelationship Between Sleep Spindles and Hypersomnia
59 Citations1994Antonio Bové, Antonio Culebras +2 more
Findings support the complaint of hypersomnia, mainly in idiopathic hypersomnia patients, in agreement with the notion that SS are generated by thalamic structures that serve a gatekeeping function during nonrapid eye movement sleep, and further suggests that their relative abundance expresses the power of that control.
Brain ResearchThe time course of σ activity and slow-wave activity during NREMS in cortical and thalamic EEG of the cat during baseline and after 12 hours of wakefulness
58 Citations1992Marike Lancel, Henk van Riezen +1 more
The present data show that, in the thalamic EEG, an inverse relation exists between spindle and slow-wave activity during baseline NREMS, and this relation is preserved after sleep deprivation.
Electroencephalography and Clinical NeurophysiologyEffect of l-DOPA or amantadine therapy on sleep spindles in Parkinsonism
43 Citations1973Francesca Puca, Albino Bricolo +1 more
An increase in spindling observed in all clinically improved patients confirms previous observations of spindle decrease in Parkinsonism.
Clinical ElectroencephalographySleep Electroencephalogram at the Early Stage of Creutzfeldt-Jakob Disease
18 Citations1992Anne Donnet, G Farnarier +3 more
Sleep EEG studies in three patients at the early stage of Creutzfeldt-Jakob disease are described: disorganized sleep architecture was noted, associated with a decrease in stage 4 and an almost complete disappearance of the REM stage.
European NeurologySleep Spindle Detection and Its Clinical Relevance
8 Citations2008A.C. Declerck, W.L.J. Martens +1 more
This paper describes one hardware and two software automated sleep spindle detection methods, used in the laboratory, and discusses the practical application of this method for clinical and scientific purposes, as for example a better quantification of the variation inSleep spindle density under influence of the intake of benzodiazepine derivatives.
Klinische NeurophysiologieDer Einfluß des Alters auf die Schlafspindel- und K-Komplex-Dichte
7 Citations1989St. Kubicki, W. Scheuler +2 more