Association of Methylphenidate-Induced Craving With Changes in Right Striato-orbitofrontal Metabolism in Cocaine Abusers: Implications in Addiction
American Journal of PsychiatryPublished 1 January 1999
Nora D. Volkow, Gene‐Jack Wang, Joanna S. Fowler, Robert Hitzemann, Burton Angrist, S. John Gatley
Citations408
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
It is indicated that dopamine enhancement is not sufficient per se to increase metabolism in these frontal regions, and activation of the right orbitofrontal cortex and right striatum in the subjects reporting craving may be one of the mechanisms underlying compulsive drug administration in addicted persons.
Abstract
Although methylphenidate increased metabolism in the superior cingulate, it only increased metabolism in orbitofrontal or prefrontal cortices in the subjects in whom it enhanced craving and mood, respectively. This indicates that dopamine enhancement is not sufficient per se to increase metabolism in these frontal regions. Activation of the right orbitofrontal cortex and right striatum (brain regions found to be abnormal in compulsive disorders) in the subjects reporting craving may be one of the mechanisms underlying compulsive drug administration in addicted persons. The predominant correlation of craving with right but not left brain regions suggests laterality of reinforcing and/or conditioned responses.
Keywords
MedicineNeuroscience
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