Chiral Brønsted Acid Catalyzed Asymmetric Baeyer–Villiger Reaction of 3‐Substituted Cyclobutanones by Using Aqueous H<sub>2</sub>O<sub>2</sub>
Angewandte Chemie International EditionPublished 6 March 2008Open access
Senmiao Xu, Zheng Wang, Xue Zhang, Xumu Zhang, Kuiling Ding
Citations226
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
A catalytic amount of a chiral Brønsted acid with aqueous H2O2 as the oxidant is sufficient for the enantioselective Baeyer–Villiger oxidation of 3-substituted cyclobutanones to give the corresponding γ-lactones in excellent yields and up to 93 % ee. The method employs benign aqueous H2O2 instead of stoichiometric amounts of a dangerous peracid.
Keywords
ChemistryBiochemistry, Genetics and Molecular BiologyEngineering
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