Hypothermic effect of apomorphine in the mouse
Journal of Pharmacy and PharmacologyPublished 1 September 1972
Kjell Fuxé, Folke Sjöqvist
Citations105
SJR quartileQ2
SJR score0.72
SNIP0.73
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Abstract
Abstract A new effect of apomorphine in lowering body temperature in mice is presented. The hypothermic effect is antagonized by haloperidol and pimozide, which block dopamine receptors in brain, and by desipramine and protriptyline which preferentially inhibit amine uptake in noradrenaline neurons. The finding may indicate that dopaminergic mechanisms are involved in temperature control in mice.
Keywords
Medicine
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