Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder
Biological PsychiatryPublished 29 March 2013Open access
Adriana Di Martino, Xi‐Nian Zuo, Clare Kelly, Rebecca Grzadzinski, Maarten Mennes, Ariel Schvarcz
Citations357
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TL;DR
Examination of patterns of dysconnection in school-age children with ASD and ADHD and typically developing children who completed a resting state functional magnetic resonance imaging scan provides evidence for both shared and distinct underlying mechanisms at the large-scale network level.
Abstract
ADHD and ASD are neurodevelopmental disorders with distinct and overlapping clinical presentations. This work provides evidence for both shared and distinct underlying mechanisms at the large-scale network level.
Keywords
MedicineNeuroscience
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When attention bias to emotional faces was equivalent between ASD and control groups, ASD was associated with greater amygdala activation, and alterations in connectivity are consistent with emotion and face processing disturbances in ASD.
Journal of Autism and Developmental DisordersADHD Symptom Subtypes in Children with Pervasive Developmental Disorder
232 Citations2006Kenneth D. Gadow, Carla J. DeVincent +1 more
Findings support the notion that ADHD may be a clinically meaningful syndrome in children with PDD, and showed a differential pattern of co-occurring psychiatric symptoms that was similar in both PDD and nonPDD samples.
Biological PsychiatryAtypical Prefrontal Connectivity in Attention-Deficit/Hyperactivity Disorder: Pathway to Disease or Pathological End Point?
217 Citations2011Conor Liston, Matthew Malter Cohen +3 more
Collectively, these studies suggest that the core symptoms of ADHD might derive from dysregulated modulation of cortical plasticity in the developing brain, resulting in altered patterns of corticocortical connectivity that might persist into adulthood.
Archives of General PsychiatryBrain Gray Matter Deficits at 33-Year Follow-up in Adults With Attention-Deficit/Hyperactivity Disorder Established in Childhood
208 Citations2011Erika Proal
Anatomic gray matter reductions are observable in adults with childhood ADHD, regardless of the current diagnosis, and exploratory analyses suggest that diagnostic remission may result from compensatory maturation of prefrontal, cerebellar, and thalamic circuitry.
Cerebral CortexReduced Functional Integration and Segregation of Distributed Neural Systems Underlying Social and Emotional Information Processing in Autism Spectrum Disorders
205 Citations2011Jeffrey D. Rudie, Zarrar Shehzad +5 more
Findings showing that ASD is characterized by a pattern of reduced functional integration as well as reduced segregation of large-scale brain networks are presented, and it is proposed that a systems-level approach may provide a more detailed characterization of the neural basis of ASD.
Brain ResearchAbnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder
200 Citations2009Xiaohua Cao, Qingjiu Cao +7 more
Results suggest that abnormal functional relationships between the putamen and the cortical-striatal-thalamic circuits as well as the default mode network may underlie the pathological basis of ADHD.
Autism ResearchMotor Learning Relies on Integrated Sensory Inputs in <scp>ADHD</scp>, but Over‐Selectively on Proprioception in Autism Spectrum Conditions
187 Citations2012Jun Izawa, Sarah E. Pekny +4 more
The results suggest that slower rate of adaptation and anomalous bias towards proprioceptive feedback during motor learning are characteristics of autism, whereas increased variability in execution is a characteristic of ADHD.
PLoS ONEResponse Properties of Human Amygdala Subregions: Evidence Based on Functional MRI Combined with Probabilistic Anatomical Maps
178 Citations2007Tonio Ball, Benjamin Rahm +4 more
The study indicates that the intrinsic functional differentiation of the human amygdala may be probed using fMRI combined with probabilistic anatomical maps, and reveals that the probabilistically defined anatomical subregions of thehuman amygdala show distinctive fMRI response patterns.
Perceptual and Motor SkillsOverflow Movements Predict Impaired Response Inhibition in Children with ADHD
158 Citations2003Stewart H. Mostofsky, Craig J. Newschaffer +1 more
Positive correlations between measures of overflow movements and measures of response inhibition suggest that closely associated neural mechanisms underlie these deficits and support hypotheses that age-inappropriate overflow reflects immaturity of cortical systems involved in automatic inhibition.
Brain ConnectivityGlobal and System-Specific Resting-State fMRI Fluctuations Are Uncorrelated: Principal Component Analysis Reveals Anti-Correlated Networks
126 Citations2011Félix Carbonell, Pierre Bellec +1 more
This work presents an alternative method for estimating global fluctuations, immune to the complications associated with the GAS, and concludes that resting-state global fluctuations and network-specific fluctuations are uncorrelated, supporting a Resting-State Linear-Additive Model.
Biological PsychiatryDimensional Brain-Behavior Relationships in Children with Attention-Deficit/Hyperactivity Disorder
89 Citations2011Camille Chabernaud, Maarten Mennes +5 more
The findings suggest that while categorical diagnostic boundaries provide an inadequate basis for understanding the pathophysiology of psychiatric disorders, psychiatric illness cannot be viewed simply as an extreme of typical neural or behavioral function.
Journal of Paediatrics and Child HealthChildhood autism spectrum disorder in the Barwon region: A community based study
82 Citations2004F Icasiano, Peter Hewson +3 more
A community database for children with autism spectrum disorder (ASD) is established to determine prevalence and identify subgroups based on key intellectual, clinical and family parameters.
Developmental ScienceControlling attention to gaze and arrows in childhood: an fMRI study of typical development and Autism Spectrum Disorders
71 Citations2011Chandan J. Vaidya, Jennifer H. Foss‐Feig +4 more
Functional anatomy was atypical in ASD children during spontaneous processing of social and nonsocial communicative cues.
European Child & Adolescent PsychiatryA twin study investigating the genetic and environmental aetiologies of parent, teacher and child ratings of autistic-like traits and their overlap
69 Citations2008Angelica Ronald, Francesca Happé +1 more
Phenotypic agreement between informants (parent, teacher and child self-report) on ratings of autistic-like traits and the genetic and environmental aetiologies of the informants’ ratings and of their covariance are investigated to discuss in relation to population screening for autism and future genetic research.
NeurologyPerceptual reasoning predicts handwriting impairments in adolescents with autism
69 Citations2010Christina T. Fuentes, Stewart H. Mostofsky +1 more
It is found that adolescents with ASD, like children, show overall worse performance on a handwriting task than do age- and intelligence-matched controls, and perceptual reasoning is the main predictor of handwriting performance.
Journal of Autism and Developmental DisordersMultiple Complex Developmental Disorder Delineated from PDD-NOS
48 Citations2006Esther I. de Bruin, Pieter F. A. de Nijs +3 more
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