The application of positron emission tomography to the study of panic disorder
American Journal of PsychiatryPublished 1 April 1986
Eric M. Reiman, Marcus E. Raichle, Eli Robins, Frank K. Butler, Peter Herscovitch, Peter T. Fox
Citations290
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections, is proposed.
Abstract
Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections, is proposed.
Keywords
PsychologyNeuroscience
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