Endogenous opiates: 1991
PeptidesPublished 1 November 1992
Gayle A. Olson, Richard D. Olson, Abba J. Kastin
Citations48
SJR quartileQ2
SJR score0.96
SNIP0.82
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TL;DR
This paper is the fourteenth installment of the annual review of research concerning the opiate system and includes papers published during 1991 involving the behavioral, nonanalgesic, effects of the endogenous opiate peptides.
Abstract
This paper is the fourteenth installment of our annual review of research concerning the opiate system. It includes papers published during 1991 involving the behavioral, nonanalgesic, effects of the endogenous opiate peptides. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal and renal function; mental illness and mood; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; general activity and locomotion; sex, pregnancy, and development; immunological responses; and other behaviors.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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Journal of Pharmacology and Experimental TherapeuticsSelective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
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American Journal of Physiology-Heart and Circulatory PhysiologyHemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals
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The British Journal of PsychiatryNeuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy
255 Citations1991Charles B. Nemeroff, Garth Bissette +2 more
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Journal of Pharmacology and Experimental TherapeuticsLack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.
240 Citations1991Antonia Mattia, Todd W. Vanderah +2 more
The data indicate that antinociceptive tolerance develops to DPDPE, [D-Ala2]deltorphin II and DAMGO but that there is no cross-tolerance between these compounds.
PsychopharmacologyImportance of delta opioid receptors in maintaining high alcohol drinking
220 Citations1991Janice C. Froehlich, M. Zweifel +3 more
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Pharmacology Biochemistry and BehaviorMarijuana's interaction with brain reward systems: Update 1991
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It is suggested that marijuana's interaction with brain reward systems is fundamentally similar to that of other abused drugs, and a specific neural model of that interaction is proposed.
Journal of NeuroscienceHyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla
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The hypothesis that RVM on-cells exert a facilitating influence on nociceptive transmission is supported, and inactivation of RVM reduces the hyperalgesia, indicating that the CNS is capable of generating a facilitating action on nOCiceptive Transmission.
Brain ResearchOntogeny and distribution of opioid receptors in the rat brainstem
171 Citations1991Ying Xia, Gabriel G. Haddad
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PsychopharmacologyEffect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys
169 Citations1991M. Kornet, C. Goosen +1 more
The reported monkey model of relapse in alcohol drinking could be a useful tool to evaluate new hypotheses and experimental treatments with respect to human alcoholism.
The Journal of PediatricsNeonatal opiate abstinence syndrome in term and preterm infants
166 Citations1991Tatiana M. Doberczak, Stephen R. Kandal +1 more
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American Journal of Clinical NutritionEffect of a tricyclic antidepressant and opiate antagonist on binge-eating behavior in normoweight bulimic and obese, binge-eating subjects
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PsychopharmacologyOpiate antagonists reduce cocaine but not nicotine self-administration
159 Citations1991William A. Corrigall, Kathleen M. Coen
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Medicine & Science in Sports & ExerciseExperimental pain thresholds and plasma beta-endorphin levels during exercise
142 Citations1991C. Droste, Mark W. Greenlee +2 more
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PsychopharmacologyRole of repeated exposure to morphine in determining its affective properties: place and taste conditioning studies in rats
131 Citations1991M. Gaiardi, M. Bartoletti +4 more
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Behavioral NeuroscienceScopolamine- and morphine-induced impairments of spontaneous alternation performance in mice: Reversal with glucose and with cholinergic and adrenergic agonists.
127 Citations1991William S. Stone, Bryan L. Walser +2 more
Experimental Biology and MedicineThe Role of Endogenous Opioids and Their Receptors in the Immune System
123 Citations1991Daniel J.J. Carr
These results seem to typify the intricate association between the immune and neuroendocrine systems through opioid pathways, and it is predicted that future endeavors will use this relationship to diagnose and treat specific diseases that have at their basis neuro endocrine and immunologic imbalances.
Psychopharmacologyβ-Endorphin-induced locomotor stimulation and reinforcement are associated with an increase in dopamine release in the nucleus accumbens
119 Citations1991Rainer Spanagel, Albert Herz +2 more
The finding that the reinforcing and locomotor stimulating effects of β-endorphin only occur at those doses which stimulate DA release suggest that this action is critical for the expression of both behavioral effects.
EndocrinologyRole of Adrenal Cortical Activation in the Immunosuppressive Effects of Chronic Morphine Treatment*
113 Citations1991H.U. Bryant, Edward W. Bernton +2 more
These studies imply that morphine-induced immunosuppression is at least in part mediated by the increase in serum corticosterone levels after implantation of the morphine pellet.
Neuroscience LettersIgG from neuropeptide FF antiserum reverses morphine tolerance in the rat
108 Citations1991John R. Lake, Maria V. Hammond +4 more
Results support the hypothesis that endogenous NPFF contributes to opiate tolerance and immunoneutralization of NPFF appears to selectively restore morphine sensitivity in opiate-tolerant animals.
Developmental Brain ResearchDifferential effects of specific opioid receptor agonists on rat pup isolation calls
108 Citations1991Susan E. Carden, Gordon A. Barr +1 more
Brain ResearchOpioid modulation and sensitization of dopamine release elicited by sexually relevant stimuli: a high speed chronoamperometric study in freely behaving rats
101 Citations1991John B. Mitchell, Alain Gratton
The results suggest that the facilitation of sexual behaviors by dopamine may be due, at least in part, to the processing of incentive motivational cues, and not necessarily to effects on copulation, itself.
Brain ResearchSex differences in opioid and non-opioid mediated predator-induced analgesia in mice
96 Citations1991Martin Kavaliers, Douglas D. Colwell
There are significant sex differences in both the opioid and non-opioid analgesic responses arising from exposure to a natural aversive stimulus, with male mice displaying a significantly greater opioid mediated predator-induced analgesia than females.
AppetiteLower pleasantness of palatable foods in nalmefene-treated human volunteers
96 Citations1991Martin R. Yeomans, Peter Wright
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Biological PsychiatryPain sensitivity in anorexia nervosa and bulimia nervosa
92 Citations1991Stefan Lautenbacher, A. Pauls +3 more
Clinical & Experimental ImmunologyBeta-casomorphin (BCM) and human colonic lamina propria lymphocyte proliferation
92 Citations1991Yoram Elitsur, G D Luk
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British Journal of PharmacologyNeuroprotective actions of GR89696, a highly potent and selective κ‐opioid receptor agonist
90 Citations1991P.J. Birch, H. L. Rogers +6 more
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82 Citations1991Keiichi Omote, Luke M. Kitahata +3 more
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Molecular Brain ResearchIsolation stress increases tyrosine hydroxylase mRNA in the locus coeruleus and midbrain and decreases proenkephalin mRNA in the striatum and nucleus accumbens
77 Citations1991Jesús A. Angulo, David Printz +2 more
The results demonstrate that a physically noninvasive stressor such as isolation of adult male rats can produce significant alterations in brain neurochemistry.
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77 Citations1991Alan Randich, C.L. Thurston +3 more
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The Journal of Clinical Endocrinology & MetabolismMarked Augmentation of Nocturnal Melatonin Secretion in Amenorrheic Athletes, but not in Cycling Athletes: Unaltered by Opioidergic or Dopaminergic Blockade*
75 Citations1991Gail A. Laughlin, Anne B. Loucks +1 more
In conclusion, athleticism in women is associated with an elevation of daytime melatonin levels independent of menstrual status, and the significance and neuroendocrine basis for the expanded melatonin secretion in athletic amenorrheic women remains to be elucidated.
Anesthesia & AnalgesiaAnesthetic Modification of Hernodynamic and Neuroendocrine Stress Responses to Cesarean Delivery in Women With Severe Preeclampsia
73 Citations1991Jaya Ramanathan, Phyllis Coleman +1 more
In the general anesthesia group, both adrenocorticotropic hormone and beta-endorphin-like immunoactivity increased significantly from base levels at skin incision and remained so throughout the study period.
Respiratory MedicinePeripheral opioid receptors and the cough reflex
72 Citations1991John J. Adcock
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PsychopharmacologyNaloxone blockade of amphetamine place preference conditioning
71 Citations1991Keith A. Trujillo, James D. Belluzzi +1 more
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European Journal of PharmacologyEffects of the analgesic agent tramadol in normal and arthritic rats: comparison with the effects of different opioids, including tolerance and cross-tolerance to morphine
69 Citations1991Valérie Kayser, Jean‐Marie Besson +1 more
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Drug and Alcohol DependenceClustering of multiple substance use and psychiatric diagnoses in opiate addicts
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Biological BulletinOpioid Systems and Magnetic Field Effects in the Land Snail, <i>Cepaea nemoralis</i>
67 Citations1991Martin Kavaliers, Klaus‐Peter Ossenkopp
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NeuroendocrinologyHypothalamic Opiatergic Tone During Pregnancy, Parturition and Lactation in the Rat
66 Citations2008D. Dondi, Roberto Maggi +3 more
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AnesthesiologyMagnitude of Acute Tolerance to Opioids Is Not Related to Their Potency
65 Citations1991Igor Kissin, Pamela T. Brown +1 more
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European Journal of PharmacologyPertussis toxin abolishes μ- and δ-opioid agonist-induced place perference
64 Citations1991Tsutomu Suzuki, Masahiko Funada +3 more
It is demonstrated that the appetitive effects of opioids result from the activation of central μ- and δ-receptors, and suggested that PTX-sensitive GTP-bindtng proteins in the central nervous system may be involved in the motivational effects of μ-and-opioid agonists.
AlcoholAlcohol drinking in rats during and following morphine injections
61 Citations1991Joseph R. Volpicelli, Ronald R. Ulm +1 more
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Developmental PsychobiologyPrenatal stress effects on exploratory activity and stress‐induced analgesia in rats
61 Citations1991Thomas F. Szuran, Ernest F. Zimmerman +3 more
The data suggest that the effects of prenatal stress on behavior are most clearly discernable when such animals are confronted with a novel or stressful situation.
Pharmacology Biochemistry and BehaviorMDMA produces a conditioned place preference and elicits ejaculation in male rats: A modulatory role for the endogenous opioids
58 Citations1991Edward J. Bilsky, Christopher L. Hubbell +2 more
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PubMedTwo opposing modes of action of beta-endorphin on lymphocyte function.
58 Citations1991P. van den Bergh, Jan Rozing +1 more
The continuous presence of beta-end (or alpha-end) in cultures of cells that had been preincubated with beta- end completely abolished the stimulatory effect, pointing towards the potential ofbeta-end to regulate T-cell function via different mechanisms.
PeptidesThe identification and structure-activity relations of a cardioactive FMRFamide-related peptide from the blue crab Callinectes sapidus
57 Citations1991Kevin G. Krajniak
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56 Citations1991Nick F. Ramsey, Jan M. van Ree
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Physiology & BehaviorStress-induced hypoalgesia and opioid inhibition of pigs' responses to restraint
56 Citations1991J. Rushen, Jan Ladewig
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Neuroscience LettersDifferential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation
56 Citations1991J.J. Benoliel, S. Bourgoin +4 more
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55 Citations1991David E. Kellstein, David J. Mayer
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54 Citations1991Dulmanie Arjune, Wayne D. Bowen +1 more
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European Journal of PharmacologyThe physical dependence liability of butorphanol: A comparative study with morphine
54 Citations1991Peter J. Horan, Ing Kang Ho
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54 Citations1991Carl R. Lupica, Thomas V. Dunwiddie
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Journal of Pharmacology and Experimental TherapeuticsImmune status and survival of opiate- and cocaine-treated mice infected with Friend virus.
52 Citations1991M Starec, B Rouveix +5 more
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Journal of Neural TransmissionNeurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors
50 Citations1991Päivi Hartikainen, Hilkka Soininen +4 more
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Acta Psychiatrica ScandinavicaA multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and β‐endorphin in melancholic patients
50 Citations1991Michaël Maes, C. Vandervorst +3 more
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Journal of Experimental Psychology Animal Behavior ProcessesAversive conditioning in the rat: Effects of a benzodiazepine and of an opioid agonist and antagonist on conditioned hypoalgesia and fear.
50 Citations1991R. Frederick Westbrook, Janet Greeley +2 more
Hypoalgesia and fear co-occurred in rats trained on a heated floor and tested for their latencies to paw lick on that floor and to step down onto a nonheated floor and these responses were extinguished, suggesting a mediation by aversive conditioning processes.
Brain ResearchConditioned place preference produced by infusion of Met-enkephalin into the medial preoptic area
50 Citations1991Anders �gmo, Mo ́nica Go ́mez
The Journal of PhysiologyMorphine actions on supraoptic oxytocin neurones in anaesthetized rats: tolerance after i.c.v. morphine infusion.
50 Citations1991K.M. Pumford, Gareth Leng +1 more
Morphine potently inhibits the firing of magnocellular oxytocin neurones in the female rat, inhibiting oxytocIn secretion, indicating dependence in mechanisms regulating the firing rate of these neurones.
Brain Researchß-Funaltrexamine (ß-FNA) decreases deprivation and opioid-induced feeding
48 Citations1991Allen S. Levine, Martha K. Grace +1 more
Data further substantiate a role for the opioid receptor in deprivation and opioid-induced feeding and show that pre-treatment with s-FNA reduced feeding stimulated by the κ opioid agonist, U-50,488H.
NeuroscienceOpioid systems in the response to inflammatory pain: Sustained blockade suggests role of κ- but not μ-opioid receptors in the modulation of nociception, behaviour and pathology
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Physiology & BehaviorStereotypic behavior and heart rate in pigs
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NeuropeptidesEffect of tachykinins in small human airways
47 Citations1991Nelly Frossard, Peter J. Barnes
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European Journal of PharmacologyEffects of acute and chronic administration of μ- and δ-opeoid agonists on the hypothalamic-pituitary-adrenocortical (HPA) axis in the rat
47 Citations1991M.Luisa Gonzalvez, M. Victoria Milanés +1 more
Data suggest that both mu- and delta-opioid receptors are involved in the regulation of HPA activity under physiological conditions and during opiate abuse.
Journal of NeuroimmunologyA possible immunoregulatory function for [Met]-enkephalin-Arg6-Phe7 involving human and invertebrate granulocytes
46 Citations1991George B. Stefano, Margaret A. Shipp +1 more
Since neutral endopeptidase 24.11 (enkephalinase; CD10/NEP) exists in invertebrate immunocyte membranes, it is demonstrated that its specific inhibitor, phosphoramidon, potentiates the effects of the heptapeptide in inducing conformational change in both human and invertebrates granulocytes.
AnesthesiologyNaloxone-sensitive, Pregnancy-induced Changes in Behavioral Responses to Colorectal Distention
46 Citations1991Hiroshi Iwasaki, J. G. Collins +2 more
This study examined the feasibility of using colorectal distention as a noxious visceral stimulus in ratregnancy-induced analgesia studies as well as the influence of naloxone on the pregnancy-induced changes in the behavioral response to a no anxious visceral stimulus.
EndocrinologyOntogeny of μ- and κ-Opiate Receptor Control of the Hypothalamo-Pituitary-Adrenal Axis in Rats*
45 Citations1991William Adamson, Rolf T. Windh +2 more
The relative ontogeny of μ- and κ-opiate receptor control of the hypothalamo-pituitary-adrenal (HPA) axis in rats was determined by evaluating ACTH and corticosterone secretion in developing rat pups.
PeptidesAge-related changes of beta-endorphin and cholecystokinin in human and rat mononuclear cells
45 Citations1991Paola Sacerdote, Massimo Breda +3 more
Since BE has been shown to participate in the modulation of the immune system, the age-related modifications of PBMC BE could play a role in the immunodepression observed during aging.
NeuroscienceEffects of central administration of beta-endorphin on brain and liver DNA synthesis in preweanling rats
45 Citations1991Jorge Bartolomé, Maria B. Bartolome +3 more
The results from these studies indicate that CNS beta-endorphin has the ability to influence DNA synthesis in central as well as in peripheral tissues.
Neuroscience LettersModulation of NMDA-induced currents by μ-opioid receptor agonist DAGO in acutely isolated rat spinal dorsal horn neurons
44 Citations1991K.I. Rusin, Mirjana Randić
Results are consistent with the possibility that DAGO might directly modulate the NMDA receptor-ion channel complex and that this action may contribute to the regulation of the strength of excitatory amino acid-mediated primary afferent neurotransmission, including nociception.
Developmental Brain ResearchCharacterization of opioid-dependent glial development in dissociated and organotypic cultures of mouse central nervous system: critical periods and target specificity
44 Citations1991Kurt F. Hauser, Anne Stiene‐Martin
The results suggest that the ability of opioids to modify glial growth is highly selective and varies depending on astrocyte type, as well as temporal and regional factors.
Pharmacology Biochemistry and BehaviorPsychological stress-induced increases in noradrenaline release in rat brain regions are attenuated by diazepam, but not by morphine
44 Citations1991Masatoshi Tanaka, Akira Tsuda +4 more
The findings suggest that psychological stress, in which an emotional factor is predominantly involved, causes increases in NA release in these brain regions examined and that these increases are attenuated only by diazepam, in contrast to the previous report, where increases in brain NA release caused by immobilization stress were attenuated not only bydiazepam but also by morphine and are enhanced by naloxone.
Brain ResearchN-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. I. Comparison of opiate receptor-deficient and opiate receptor-rich strains of mice
43 Citations1991Przemysław Marek, Gayle G. Page +2 more
It is suggested that the NMDA receptor is critically involved in the non-opioid component of SSIA, and it was nearly abolished by a combination of these drugs.
Pharmacology Biochemistry and Behavior“Paradoxical” effects of morphine on antipredator defense reactions in wild and laboratory rats
41 Citations1991D. Caroline Blanchard, Abraham J. Weatherspoon +4 more
A very widespread pattern of reliable sex or sex x drug effects in the Anxiety/Defense Test Battery was in good agreement with previous reports of sex differences in these tests, with females generally more defensive than males.
Life SciencesPersistently low natural killer cell activity and circulating levels of plasma beta endorphin: Risk factors for infectious disease
41 Citations1991Sandra M. Levy, John D. Fernstrom +5 more
The findings reported here suggest that the observed LNK activity might be affected by circulating levels of plasma beta endorphin, as lowerEndorphin levels predicted the LNK pattern, which in turn, predicted higher illness morbidity.
Brain ResearchHippocampal μ-receptors mediate opioid reinforcement in the CA3 region
41 Citations1991Karen E. Stevens, Goichi Shiotsu +1 more
It is reported here that drug-naive rats rapidly learn to self-administer the opioid peptide dynorphin A in the CA3 region of hippocampus, and that this behavior is blocked by co-administration of the non-selective opiate antagonist naloxone.
European Journal of Pharmacology Molecular Pharmacologyμ-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposure
41 Citations1991Bernard J. Van Vliet, Taco J. De Vries +3 more
Tolerance to morphine may be caused by the fact that morphine is acting against up-regulated signal transduction mechanisms rather than by mu receptor desensitization, and this enhanced effector system function may be involved in opioid dependence.
Molecular Brain ResearchAlterations in somatostatin and proenkephalin mRNA in response to a single amygdaloid stimulation versus kindling
40 Citations1991Hisaharu Shinoda, N. Suzan Nadi +1 more
The data support the idea that changes of SS mRNA in hippocampus and of PE mRNA in olfactory cortex may be related to kindling, and point out the importance of using animals which receive a single electrical stimulus, rather than sham-operated animals, as controls.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiologykappa-Opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury
40 Citations1991Robert Vink, P. S. Portoghese +1 more
The hypothesis that kappa-opioid receptors mediate pathophysiological changes after traumatic brain injury and that the beneficial effects of opioid-receptor antagonist may result from improvement of posttraumatic cellular bioenergetics is supported.
Psychosomatic MedicineDepression and type A behavior pattern in patients with coronary artery disease: relationships to painful versus silent myocardial ischemia and beta-endorphin responses during exercise.
40 Citations1991Kathleen C. Light, M Herbst +5 more
Findings suggest that in patients with ischemic heart disease, there may be a relationship between depression and anginal pain which may in part involve a blunted or absent beta‐endorphin response.
European Journal of PharmacologyCharacteristics of μ and δ opioid binding sites in striatal slices of morphine-tolerant and -dependent mice
39 Citations1991Essam E. Abdelhamid, A.E. Takemori
The enhancement in the binding affinity of DAMGO and naloxone and the increased density of DADLE binding sites paralleled the development of morphine tolerance and dependence and [D-Pen2, D-Pen5]enkephalin cross-tolerance in whole animals.
Journal of NeuroimmunologyModulation of natural killer cell-mediated lysis by corticotropin-releasing neurohormone
39 Citations1991Sy-Jye Christine Leu, V SINGH
It is hypothesized that the CRF modulates NK cell-mediated lysis via initial stimulation of monocytes to produce IL-1 triggering the release by B cells of beta E for the stimulation of NK cell function.
Pharmacology Biochemistry and BehaviorOpioid-dependent behaviors in infant rats: Effects of prenatal exposure to ethanol
38 Citations1991Priscilla Kehoe, William J. Shoemaker
Since both vocalization and analgesia responses have been determined to be modulated by the endogenous opioid system, the aberrant responses of the prenatal-ethanol-exposed offspring can be interpreted as failures to respond by opioid release/secretion to appropriate stimuli.
Brain ResearchVentral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats
37 Citations1991Diane C. Hoffman, Thomas E.G. West +1 more
It is confirmed that opiate actions in the VP contribute to opiate-induced locomotion and suggest that mu and to some extent delta receptors are involved in this behavior.
Journal of Pharmacology and Experimental TherapeuticsBeta-endorphin: a highly selective endogenous opioid agonist for presynaptic mu opioid receptors.
37 Citations1991Anton N. M. Schoffelmeer, Glenn D. Warden +2 more
In the presence of physiological cations (in Krebs-4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid buffer) at 37 degrees C the Ki value's of beta-endorphin for mu- and delta-opioid receptor binding sites in rat neocortical membranes amounted to about 9 and 22 nM, respectively.
The Journal of PhysiologyThe peptide FMRFamide activates a divalent cation‐conducting channel in heart muscle cells of the snail Lymnaea stagnalis.
37 Citations1991B. L. Brezden, Paul R. Benjamin +1 more
Both sodium and barium currents were initiated when the peptides were applied to the cell outside of the patch pipette indicating that a secondary messenger is likely to be involved in the FMRFamide response.
Circulation ResearchOpioids in cerebrospinal fluid in hypotensive newborn pigs.
37 Citations1991William M. Armstead, R. Mirro +3 more
Opioid profiles were assessed qualitatively by radioreceptor assay, and individual opioids were measured quantitatively by radioimmunoassay to determine the effects of topically administered opioids on pial arteriolar diameter during normotension and hypotension.
Pharmacology Biochemistry and BehaviorEEG evidence that morphine and an enkephalin analog cross the blood-brain barrier
36 Citations1991Abba J. Kastin, Mary A. Pearson +1 more
Naltrexone significantly blocked the EEG effects of morphine and the enkephalin analog, but methyl naltrex one failed to do so, providing biological evidence that an opiate peptide can cross the BBB to affect the activity of the brain.
PsychopharmacologyDiscriminative stimulus effects of spiradoline, a kappa-opioid agonist
36 Citations1991Stephen G. Holtzman, Leonard Cook +1 more
The results indicate that the discriminative effects of spiradoline are mediated by kappa-opioid receptors; meaningful mu-opIOid and PCP/sigma components of action were not in evidence.
Progress in Neuro-Psychopharmacology and Biological PsychiatryOpiate-dopamine interactions in the neural substrates of acoustics startle gating in the rat
36 Citations1991Neal R. Swerdlow, S. Barak Caine +1 more
Dopaminergic mechanisms that modulate PPI in the rat may be regulated by opiate systems that act presynaptic to the DA receptor; brain opiate receptors may not have direct effects on startle gating independent of this opiate-DA interaction.
NeuropharmacologyMorphine stimulation of mesolimbic and mesocortical but not nigrostriatal dopamine release in the rat as reflected by changes in 3-methoxytyramine levels
35 Citations1991Paul L. Wood, Tadimeti S. Rao
The data suggest that the mesolimbic and mesocortical dopaminergic projections in the rat can be activated by opiates and lead to changes in cortical function which may be involved in some of the complex behavioral actions of opiate and opioid peptides.
Hearing ResearchEffects of opioid be drugs on auditory evoked potentials suggest a role of lateral olivocochlear dynorphins in auditory function
35 Citations1991Tony L. Sahley, Robin B. Kalish +2 more
Stimulatory action of kappa-agonists on auditory-evoked potential amplitudes appears to represent a physiological role of the lateral olivocochlear efferent innervation.
Life SciencesMorphine-6-glucuronide contributes to rewarding effects of opiates
35 Citations1991Frances V. Abbott, Keith B.J. Franklin
It is reported here that M6G is also a powerful behavioral reinforcer in the conditioned place preference test in rats, indicating that it has rewarding properties, and is therefore likely to have abuse potential.
Brain ResearchElectroacupuncture in rats: evidence for naloxone and naltrexone potentiation of analgesia
34 Citations1991Daniel F. Bossut, Zhangxiang Huang +2 more
The results indicate that EA analgesia in rats is a variable phenomenon even when laboratory methods are rigorously replicated, and suggests the existence of an opioid anti-analgesic system or that NAL and NTX acquired analgesic properties following EA.
PsychopharmacologyNaloxone modulates the behavioral effects of cholinergic agonists and antagonists
34 Citations1991David L. Walker, Timothy McGlynn +3 more
Across three diverse measures, naloxone produced effects similar to those previously reported for glucose, consistent with the hypothesis that release of cholinergic activity from opiate inhibition may contribute to glucose effects on behavior.
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