The preceptor experience: a qualitative study of perceptions of nurse preceptors regarding the preceptor role.
PubMedPublished 20 July 1995
Barbara Stevenson, James Doorley, Gail Moddeman, M Benson-Landau
Citations42
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TL;DR
Findings from this study can be used to develop preceptor programs that increase job satisfaction for preceptors and improve the learning environment for orientees.
Abstract
This qualitative, exploratory, and descriptive survey was undertaken to identify benefits and disadvantages of the preceptor role as perceived by nurse preceptors. Information regarding rewards preceptors perceived as desirable also was obtained. Findings from this study can be used to develop preceptor programs that increase job satisfaction for preceptors and improve the learning environment for orientees.
Keywords
Nursing
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37 Citations2019Yue-Chen Chang, Ziwei Han +7 more
GPER may improve the renal interlobular artery vascular function by increasing the NO content, thereby protecting against renal IR injury.
Neural Regeneration ResearchGPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury
37 Citations2019Jun‐Qiang Si, Li Li +6 more
OncotargetA genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells
37 Citations2017Marco Pupo, Alexandre Bodmer +4 more
Surveying a small set of CAFs from breast cancer biopsies, it is found that a relatively common single nucleotide polymorphism, which results in the expression of a GPER variant with the amino acid substitution P16L, is associated with the nuclear localization of GPER.
PLoS BiologyThe developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism
35 Citations2019Lili Tian, Weijuan Shao +4 more
The scope of functions of the Wnt pathway effector β-cat/TCF is expanded, as it can also mediate hepatic functions of E2 during adulthood and can be attenuated by the G-protein-coupled estrogen receptor (GPER) antagonist G15.
BMB ReportsG protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastric cancer
35 Citations2019Seon‐Jin Lee, Tae Woo Kim +5 more
The data suggest that the induction of ER stress via GPER expression may increase G-1-induced cell death in Gastric cancer cells, which may contribute to a new paradigm shift in gastric cancer therapy.
PubMedExpression of G protein-coupled estrogen receptor in irritable bowel syndrome and its clinical significance.
35 Citations2014Bin Qin, Lei Dong +6 more
The present study demonstrated the expression of GPER in human colonic mucosa and its correlation with abdominal pain severity and for the first time, demonstrated the relationship between GPER and classical estrogen receptors in the colon of IBS patients and healthy controls.
Scientific ReportsGPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin
34 Citations2019Kathleen D. Triplett, Srijana Pokhrel +10 more
A novel role for GPER activation in skin innate defense against infectious disease suggests that G-1 may have clinical utility in patients with epithelial permeability barrier dysfunction or who are otherwise at increased risk of S. aureus infection, including those with atopic dermatitis or cancer.
Archives of Biochemistry and Biophysics17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor
34 Citations2018Hiroyuki Yasuda, Annri Sonoda +7 more
It is demonstrated that E2 treatment induces NETosis via not only ERα/ERβ but also GPR30 in neutrophil-like HL-60 cells, and the effects of estrogen (17-β-estradiol; E2) on NETosis are investigated, focusing on mechanisms associated with estrogen membrane receptor (GPR30) in neutrophic cells.
International Journal of Molecular MedicineGenistein improves viability, proliferation and mitochondrial function of cardiomyoblasts cultured in physiologic and peroxidative conditions
33 Citations2019Serena Farruggio, Giulia Raina +5 more
Evaluating the protective effects exerted by genistein on cardiomyoblasts (H9C2) against oxidative stress, nitric oxide (NO) release, viability, proliferation/migration and mitochondrial function showed that phytoestrogens and estrogens can increase cell viability, migration, mitochondrial membrane potential, mitochondrial oxygen consumption and oxidant/ant antioxidants system.
Neural PlasticityGPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior
33 Citations2020Yi Zheng, Meimei Wu +11 more
It is demonstrated that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain structures critically involved in mood control and an important role of GPER at multiple sites in regulation of the H PA axis and mood.
Clinical ScienceActivation of G protein–coupled estrogen receptor protects intestine from ischemia/reperfusion injury in mice by protecting the crypt cell proliferation
33 Citations2019Shiquan Chai, Kaixuan Liu +11 more
Findings demonstrate that GPER activation can prompt epithelial cell repair following intestinal injury, which occurred at least in part by inhibiting the iNOS expression in intestinal stem cells (ISCs).
Toxicology4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells
32 Citations2013Li Yang, Yan Chen +6 more
Data indicate that OHT contributes to the production of proteolyzed cyclin E via GPR30 with augmented migration in MCF-7 cells, suggesting involvement of EGFR signaling.
Metabolic Brain DiseaseEstrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen
31 Citations2017Hilary Seifert, Gil Benedek +4 more
Pretreatment with E2 almost completely prevents intact female and male mice from developing clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) by promoting various regulatory immune cell phenotypes, and E2 protection against EAE promotes highly overlapping immunoregulatory subsets in OVX females and males.
Journal of Clinical InvestigationMolecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance
30 Citations2022Yingfu Jiao, Po Gao +22 more
The data strongly indicate that GPER is a marker for GABAergic ON cells and illuminate the mechanisms underlying hormonal regulation of pain and analgesia, thus highlighting GPER as a promising target for the treatment ofPain and opioid tolerance.
American Journal of Physiology-Cell PhysiologyNeonatal cardiomyocyte hypertrophy induced by endothelin-1 is blocked by estradiol acting on GPER
30 Citations2017Gleisy Kelly Neves Gonçalves, Sérgio Scalzo +4 more
E2 plays a key role in antagonizing ET-1-inducedhypertrophy in cultured neonatal cardiomyocytes through GPER signaling by a mechanism involving activation of the PDK1 pathway, which would prevent the increase of ERK1/2 activity and consequently the development of hypertrophy.
OncotargetGPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer
30 Citations2017Francesca Cirillo, Michele Pellegrino +13 more
The data suggest that estrogens in ER-negative cell contexts may engage the alternate GPER signaling toward CYP1B1 regulation, which should be taken into account in setting novel pharmacological approaches targeting breast cancer development.
Journal of Lipid ResearchA novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice
27 Citations2020Chelsea DeLeon, Helen H. Wang +6 more
2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA) may be a new agent for effectively treating cholesterol gallstone disease in women by inhibiting the GPER signaling pathway in female mice.
Biochemical and Biophysical Research Communications17β-Estradiol inhibits cardiac fibroblast growth through both subtypes of estrogen receptor
27 Citations2003Tokumitsu Watanabe, Masahiro Akishita +7 more
It is suggested that E2 inhibits CF growth and that both ER subtypes mediate the effect comparably and redundantly.
The Journals of Gerontology Series ACardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension
27 Citations2018A Alencar, Guilherme Carneiro Montes +13 more
G1 reversed PH-related cardiopulmonary dysfunction and exercise intolerance in female rats, a finding that may have important implications for the ongoing clinical evaluation of new drugs for the treatment of the disease in females after the loss of endogenous estrogens.
Journal of Pharmacology and Experimental TherapeuticsActivation of the G Protein–Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell
25 Citations2020Qian Wang, Li Zhao +11 more
It is demonstrated that G protein–coupled estrogen receptor (GPER) activation prevents dextran sulfate sodium–induced acute colitis by protecting the crypt cells, showing that it inhibited the crypt cell apoptosis and protected proliferation of Crypt cells, which resulted in protection of the intestinal mucosal barrier.
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