Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
Sleep SciencePublished 30 September 2015Open access
Camila Hirotsu, Sérgio Tufik, Mônica L. Andersen
Citations429
SJR quartileQ2
SJR score0.59
SNIP0.76
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
An overall view of the relationship between sleep, stress, and metabolism from basic physiology to pathological conditions is provided, highlighting effective treatments for metabolic disturbances.
Abstract
Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism through hypothalamic-pituitary-adrenal (HPA) axis activation. Sleep deprivation and sleep disorders are associated with maladaptive changes in the HPA axis, leading to neuroendocrine dysregulation. Excess of glucocorticoids increase glucose and insulin and decrease adiponectin levels. Thus, this review provides overall view of the relationship between sleep, stress, and metabolism from basic physiology to pathological conditions, highlighting effective treatments for metabolic disturbances.
Keywords
PsychologyNeuroscience
The LancetImpact of sleep debt on metabolic and endocrine function
3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
Annals of Internal MedicineBrief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite
2,435 Citations2004Karine Spiegel, Esra Tasali +2 more
In this study, 12 young, healthy, normal-weight men exhibited reductions in the satiety hormone leptin, increases in the hunger hormone ghrelin, and increases in hunger after 2 nights of only 4 hours of sleep compared with after two nights of 10 hours ofSleep, suggesting inadequate sleep seems to influence the hormones that regulate satiety and hunger.
PLoS MedicineShort Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index
2,430 Citations2004Shahrad Taheri, Ling Lin +3 more
SLEEPMeta-Analysis of Short Sleep Duration and Obesity in Children and Adults
2,031 Citations2008Francesco P. Cappuccio, Frances Taggart +5 more
Cross-sectional studies from around the world show a consistent increased risk of obesity amongst short sleepers in children and adults, and a estimate of the risk is obtained.
ScienceA Transgenic Model of Visceral Obesity and the Metabolic Syndrome
1,761 Citations2001Hiroaki Masuzaki, J. Paterson +5 more
Increased adipocyte 11β HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome.
NatureThe role of neuropeptide Y in the antiobesity action of the obese gene product
1,513 Citations1995Thomas W. Stephens, Margret B. Basinski +15 more
ObesityShort Sleep Duration and Weight Gain: A Systematic Review
1,509 Citations2008Sanjay R. Patel, Frank B. Hu
This work reviews the literature regarding short sleep duration as an independent risk factor for obesity and weight gain and suggests sleep deprivation may influence weight through effects on appetite, physical activity, and/or thermoregulation.
Journal of Applied PhysiologySleep loss: a novel risk factor for insulin resistance and Type 2 diabetes
1,177 Citations2005Karine Spiegel, Kristen L. Knutson +3 more
The Journal of Clinical Endocrinology & MetabolismLeptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin
1,001 Citations2004Karine Spiegel, Rachel Leproult +4 more
Sleep modulates a major component of the neuroendocrine control of appetite, and the effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values.
Endocrine Reviews11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response
973 Citations2004Jeremy Tomlinson, Elizabeth A. Walker +6 more
It is speculated that hexose-6-phosphate dehydrogenase activity and therefore reduced nicotinamide-adenine dinucleotide phosphate supply may be crucial in determining the directionality of 11beta-HSD1 activity.
The Journal of Clinical Endocrinology & MetabolismOn the Interactions of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Sleep: Normal HPA Axis Activity and Circadian Rhythm, Exemplary Sleep Disorders
962 Citations2005Theresa M. Buckley, Alan F. Schatzberg
Sleep Medicine ReviewsRestricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity
888 Citations2008Peter Meerlo, Andrea Sgoifo +1 more
Experimental studies in rodents show that chronic sleep restriction may gradually alter neuroendocrine stress responses as well as the central mechanisms involved in the regulation of these responses, which support the view that insufficient sleep, by acting on stress systems, may sensitize individuals to stress-related disorders.
The Journal of Clinical Endocrinology & MetabolismChronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications
837 Citations2001Alexandros N. Vgontzas, Edward O. Bixler +6 more
It is concluded that insomnia is associated with an overall increase of ACTH and cortisol secretion, which, however, retains a normal circadian pattern, consistent with a disorder of central nervous system hyperarousal rather than one of sleep loss, which is usually associated with no change or decrease in cortisol secretion or a circadian disturbance.
Nature Reviews EndocrinologyEffects of poor and short sleep on glucose metabolism and obesity risk
829 Citations2009Karine Spiegel, Esra Tasali +2 more
The laboratory and epidemiologic evidence suggests how sleep loss, either behavioral or disease-related, and poor quality of sleep might promote the development of obesity and diabetes mellitus, and exacerbate existing endocrine conditions.
Frontiers in NeuroendocrinologyFeast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow
795 Citations1993Mary F. Dallman, Alison M. Strack +5 more
The hypothesis proposed in this review is that normal diurnal rhythms in the hypothalamic-pituitary-adrenal (HPA) axis are highly regulated by activity in medial hypothalamic nuclei to effect an interaction between corticosteroids and insulin such that optimal metabolism results in response to changes in the fed or fasted state of the animal.
SLEEPSleep Loss Results in an Elevation of Cortisol Levels the Next Evening
748 Citations1997Rachel Leproult, Georges Copinschi +2 more
It is concluded that even partial acute sleep loss delays the recovery of the HPA from early morning circadian stimulation and is thus likely to involve an alteration in negative glucocorticoid feedback regulation.
American Journal of Clinical NutritionSleep curtailment is accompanied by increased intake of calories from snacks
709 Citations2008Arlet Nedeltcheva, J. Kilkus +4 more
Recurrent bedtime restriction can modify the amount, composition, and distribution of human food intake, and sleeping short hours in an obesity-promoting environment may facilitate the excessive consumption of energy from snacks but not meals.
SLEEPThe Association Between Short Sleep Duration and Obesity in Young Adults: a 13-Year Prospective Study
670 Citations2004Gregor Hasler, Daniel J. Buysse +6 more
This study showed an association between short sleep duration and obesity and a negative association betweenSleep duration and body mass index in young adults and a trend for average change rate of weight gain to be negatively associated with average change rates of sleep duration.
The Journal of Clinical Endocrinology & MetabolismTissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity
632 Citations2001Eva Rask, Tommy Olsson +5 more
In obesity, reactivation of cortisone to cortisol by 11beta-HSD1 in liver is impaired, so that plasma cortisol levels tend to fall, and there may be a compensatory increase in cortisol secretion mediated by a normally functioning hypothalamic-pituitary-adrenal axis.
International Journal of ObesityThe role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes
631 Citations2000G P Chrousos
Stress-induced hypercortisolism and visceral obesity and their cardiovascular and other sequelae increase the all-cause mortality risk of affected subjects by 2–3-fold and curtail their life expectancy by several years.
The Journal of Clinical Endocrinology & MetabolismThe Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis
608 Citations2009Panagiotis Anagnostis, Vasilios G. Athyros +3 more
The present review summarizes the evidence on the potential role of cortisol in the pathogenesis of MetS and discusses new therapeutic approaches for patients with MetS, which may be partly associated with chronic stress and/or low birth weight.
Diabetes CareObstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes
601 Citations2009Gary D. Foster, Mark Sanders +10 more
Physicians should be particularly cognizant of the likelihood of OSA in obese patients with type 2 diabetes, especially among individuals with higher waist circumference and BMI.
DiabetesSleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
596 Citations2010Orfeu M. Buxton, Milena Pavlova +4 more
Sleep restriction (5 h/night) for 1 week significantly reduces insulin sensitivity, raising concerns about effects of chronic insufficient sleep on disease processes associated with insulin resistance.
EndocrinologyChronic Stress Promotes Palatable Feeding, which Reduces Signs of Stress: Feedforward and Feedback Effects of Chronic Stress
579 Citations2004Norman C. Pecoraro, Faith Reyes +3 more
The model of chronic effects of stress and GCs, showing a stressor-induced preference for comfort food, and a comfort-food reduction in activity of the HPA axis, tends to support this study.
Archives of Disease in ChildhoodThe link between short sleep duration and obesity: we should recommend more sleep to prevent obesity
504 Citations2006Shahrad Taheri
Sleep may affect energy balance, and good sleep could be part of the obesity prevention approach, as even small changes in the energy balance are beneficial.
Pharmacological ReviewsOrexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
474 Citations2009Natsuko Tsujino, Takeshi Sakurai
The findings suggest that the orexin system interacts with systems that regulate emotion, reward, and energy homeostasis to maintain proper vigilance states and may be a potentially important therapeutic target for treatment of sleep disorder, obesity, emotional stress, and addiction.
American Journal of Clinical NutritionShort sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals
461 Citations2011Marie‐Pierre St‐Onge, Amy L. Roberts +5 more
The data show that a reduction in sleep increases energy and fat intakes, which may explain the associations observed between sleep and obesity.
Journal of NeuroscienceInteraction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
460 Citations2004Raphaëlle Winsky‐Sommerer, Akihiro Yamanaka +7 more
It is proposed that, after stressor stimuli, CRF stimulates the release of hypocretins and that this circuit contributes to activation and maintenance of arousal associated with the stress response.
American Journal of Human BiologyIs obesity associated with poor sleep quality in adolescents?
435 Citations2002Neeraj Gupta, William H. Mueller +2 more
Inadequate and poor sleep quality in adolescents may be important factors to consider in the prevention of childhood obesity.
American Journal of Physiology-Endocrinology and MetabolismEffects of glucocorticoids on energy metabolism and food intake in humans
412 Citations1996P. Antonio Tataranni, D E Larson +4 more
The data suggest that therapeutic doses of glucocorticoids induce obesity mostly by increasing energy intake, an effect which may be related to the ability of gluc Cocorticoid to act directly or indirectly on the central regulation of appetite.
Archives of Internal MedicineOverweight and Obese Patients in a Primary Care Population Report Less Sleep Than Patients With a Normal Body Mass Index
403 Citations2005Robert Daniel Vorona, Maria P. Winn +4 more
It is found that reduced amounts of sleep are associated with overweight and obese status and interventions manipulating total sleep time could elucidate a cause-and-effect relationship between insufficient sleep and obesity.
American Journal of Clinical NutritionShort-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men
399 Citations2009Sebastian Schmid, Manfred Hallschmid +6 more
Test the hypothesis that acute sleep loss decreases physical activity while increasing food intake, thereby shifting 2 crucial behavioral components of energy homeostasis toward weight gain, and short-term sleep loss neither increased food intake nor affected concentrations of the hunger-regulating hormones leptin and ghrelin.
Journal of Psychosomatic ResearchChronic insomnia and activity of the stress system
395 Citations1998Alexandros N. Vgontzas, Constantine Tsigos +6 more
It is concluded that, in chronic insomnia, the activity of both limbs of the stress system (i.e., the HPA axis and the sympathetic system) relates positively to the degree of objective sleep disturbance.
International Journal of EndocrinologyImpact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
392 Citations2010M. Balbo, Rachel Leproult +1 more
Further research to delineate the functional links between sleep and HPA axis activity is needed to fully understand the pathophysiology of these syndromes and to develop adequate strategies of prevention and treatment.
Annals of Internal MedicineInsufficient Sleep Undermines Dietary Efforts to Reduce Adiposity
390 Citations2010Arlet Nedeltcheva, J. Kilkus +3 more
The amount of human sleep contributes to the maintenance of fat-free body mass at times of decreased energy intake and Lack of sufficient sleep may compromise the efficacy of typical dietary interventions for weight loss and related metabolic risk reduction.
International Journal of ObesityTime spent watching television, sleep duration and obesity in adults living in Valencia, Spain
364 Citations2000Jesús Vioqué, A Torres +1 more
Time spent watching television and a low physical activity at work were related to obesity in adults in Spain, and the inverse association between obesity and sleep duration deserves further research.
Molecular and Cellular EndocrinologyCircadian rhythms in the hypothalamo–pituitary–adrenal (HPA) axis
363 Citations2011Andries Kalsbeek, Rianne van der Spek +4 more
The adrenal gland is still of prime importance for understanding how the oscillations of clock genes in peripheral tissues result in functional rhythms of these tissues, whereas it has become even more evident that adrenal glucocorticoids are key in the resetting of the circadian system after a phase-shift.
Current Opinion in Endocrinology Diabetes and ObesityStress and obesity: the role of the hypothalamic–pituitary–adrenal axis in metabolic disease
337 Citations2009Mousumi Bose, Blanca Oliván +1 more
Evidence is provided for the relationship between chronic stress, alterations in HPA activity, and obesity and its interactions with other factors will be important in developing effective treatments for obesity and related metabolic diseases.
Trends in Pharmacological SciencesAnimal models as simulations of depression
331 Citations1991Paul Willner
The most familiar usage of animal models of depression is as antidepressant screening tests, but Paul Willner reviews their usage in a different context--as simulations of depression.
The Journal of PhysiologyEnergy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans
316 Citations2010Christopher Jung, Edward L. Melanson +4 more
The finding that sleep deprivation increases energy expenditure should not be interpreted thatSleep deprivation is a safe or effective strategy for weight loss as other studies have shown that chronic sleep deprivation is associated with impaired cognition and weight gain.
NeuroendocrinologyEffects of Corticotropin-Releasing Factor and Growth Hormone-Releasing Factor on Sleep and Activity in Rats
311 Citations2008Cindy L. Ehlers, Trisha K. Reed +1 more
Electroencephalographic and behavioral findings seen following CRF and GRF are consistent with the behaviors frequently correlated with the known circadian timing of the release of corticosteroids and growth hormone during the sleep-waking cycle in rat and human.
MetabolismMetabolic consequences of stress during childhood and adolescence
308 Citations2011Panagiota Pervanidou, George P. Chrousos
The understanding of stress mechanisms leading to metabolic abnormalities in early life may lead to more effective prevention and intervention strategies of obesity-related health problems.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyRhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation
301 Citations2004Balázs Bodosi, János Gardi +4 more
A strong relationship between feeding and the diurnal rhythm of leptin is suggested and that feeding also fundamentally modulates the di nighttime rhythm of ghrelin.
Diabetes Research and Clinical PracticeSleep-disordered breathing and type 2 diabetes
295 Citations2008Jonathan E. Shaw, Naresh M. Punjabi +3 more
Supporting the need for further research into the links between sleep-disordered breathing and diabetes, the International Diabetes Federation Taskforce on Epidemiology and Prevention strongly recommends that health professionals working in both type 2 diabetes and SDB adopt clinical practices to ensure that a patient presenting with one condition is considered for the other.
American Journal of Physiology-Endocrinology and MetabolismGhrelin promotes slow-wave sleep in humans
290 Citations2003J Weikel, Adam Wichniak +8 more
It is suggested that ghrelin is an endogenous sleep-promoting factor that appears to be complementary to the already described effects of the peptide in the regulation of energy balance and a common stimulus of the somatotropic and hypothalamo-pituitary-adrenocortical systems.
ScienceDifferential Rescue of Light- and Food-Entrainable Circadian Rhythms
267 Citations2008Patrick M. Fuller, Jun Lü +1 more
It is demonstrated that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms, which are powerfully entrained by the light-dark cycle.
The Journal of Clinical Endocrinology & MetabolismCortisol Secretion Is Inhibited during Sleep in Normal Man*
267 Citations1983Elliot D. Weitzman, Janet C. Zimmerman +2 more
The inhibitory effect of the behavioral complex of sleeping on cortisol secretion superimposed on its endogenous circadian and ultradian rhythm is demonstrated and may be used to entrain and time the period and phase of biological rhythms in relation to shift work, sleep deprivation, and transmeridian jet travel.
Journal of NeuroendocrinologySleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men
262 Citations2003Janet Mullington, Jean L. Chan +7 more
Evidence that sleep influences the nocturnal leptin profile is provided, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.
NeuroendocrinologyEffects of Intravenous Corticotropin-Releasing Hormone upon Sleep-Related Growth Hormone Surge and Sleep EEG in Man
261 Citations2008Florian Holsboer, U. von Bardeleben +1 more
H-CRH induced a decrease of REM and slow wave sleep while the amount of more shallow sleep (stages I and II) increased and its effects upon sleep structure were more pronounced during the second part of the night.
DiabetologiaSelective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice
259 Citations2002Pēteris Alberts, Linda Engblom +7 more
Results suggest that a selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 can become a new approach for lowering blood glucose concentrations in Type II diabetes.
Journal of Psychiatric ResearchNeurochemical regulation of sleep
252 Citations2006Axel Steiger
Recently synthetic GABA(A) agonists, particularly gaboxadol and the GABA reuptake inhibitor tiagabine were shown to differ distinctly in their action from allosteric modulators of the GABA( A) receptor like benzodiazepines as they promote slow-wave sleep, decrease wakefulness and do not affect REMS.
DiabetesAdipocyte-Specific Glucocorticoid Inactivation Protects Against Diet-Induced Obesity
252 Citations2005Erin E. Kershaw, Nicholas M. Morton +4 more
The data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome.
Journal of NeuroendocrinologySleep Restriction Alters the Hypothalamic‐Pituitary‐Adrenal Response to Stress
249 Citations2002Peter Meerlo, Muriel Koehl +2 more
The results show that sleep loss not only is a mild activator of the HPA axis itself, but also affects the subsequent response to stress.
American Journal of Clinical NutritionAcute sleep deprivation reduces energy expenditure in healthy men
239 Citations2011Christian Benedict, Manfred Hallschmid +6 more
The findings show that one night of sleep deprivation acutely reduces energy expenditure in healthy men, which suggests that sleep contributes to the acute regulation of daytime energy expenditures in humans.
EndocrinologyRegulation of Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue: Tissue-Specific Induction by Cytokines*
220 Citations2001Jeremy Tomlinson, J. Moore +7 more
The Journal of PediatricsSex Differences in the Association between Sleep and Body Mass Index in Adolescents
219 Citations2005Kristen L. Knutson
Longer sleep duration was weakly associated with lower BMI and risk of overweight among male adolescents only, and this sex-related difference may be due to differences in the physiology of puberty or in sleep characteristics.
The Journal of Clinical Endocrinology & MetabolismCircadian and Ultradian Variations of Leptin in Normal Man under Continuous Enteral Nutrition: Relationship to Sleep and Body Temperature
219 Citations1998Chantal Simon, Claude Gronfier +2 more
Archives of Internal MedicineSleep Duration and Body Mass Index in a Rural Population
214 Citations2006Neal Kohatsu
Data support an association between short sleep duration and higher BMI in this rural population, which is consistent with the relationship found in other settings.
Journal of Clinical Sleep MedicineThe Role of Sleep Duration in the Regulation of Energy Balance: Effects on Energy Intakes and Expenditure
213 Citations2013Marie‐Pierre St‐Onge
Evaluated studies that have assessed food intake, energy expenditure, and leptin and ghrelin levels after periods of restricted and normal sleep suggest that restricting sleep may lead to weight gain via increased food intake but the effects on energy expenditure are mixed.
Obesity ResearchHypocretin Deficiency in Narcoleptic Humans Is Associated with Abdominal Obesity
200 Citations2003Simon W. Kok, Sebastiaan Overeem +5 more
The fact that patients with IH had a lower BMI than narcoleptics supports the notion that excessive daytime sleepiness cannot account for excess body fat in narcoLEptic patients.
Journal of NeurochemistryChanges in brain gene expression after long‐term sleep deprivation
199 Citations2006Chiara Cirelli, Ugo Faraguna +1 more
S sustained sleep loss may trigger a generalized inflammatory and stress response in the brain, and be compared to short‐term and long‐term sleep‐deprived rats, and found that acute and chronic sleep loss led to some differences at the molecular level.
Behavioural Brain ResearchSleep function(s) and cerebral metabolism
194 Citations1995Pierre Maquet
The research in the field of the brain metabolism during sleep has now come to a turning point, since the confirmation of sizeable cerebral anabolic processes would provide an outstanding argument in favour of the restorative theory of sleep.
Journal of Psychiatric ResearchPhysiological and psychological differences between good and poor sleepers
194 Citations1986Kirstine Adam, Maureen Tomeny +1 more
It is concluded that those who complain of poor sleep have also metabolic differences from good sleepers, with the poor sleepers being significantly more inaccurate.
Current Diabetes ReportsBiological Basis of Depression in Adults with Diabetes
191 Citations2010Shivam Champaneri, Gary S. Wand +3 more
Recent evidence showing alterations of these three biological systems—HPA axis, SNS, and inflammatory cascade—in depression, diabetes, and diabetes-related risk factors is reviewed.
Scandinavian Journal of Work Environment & HealthThe effects of shift work on body weight change − a systematic review of longitudinal studies
188 Citations2011A. van Drongelen, C.R.L. Boot +3 more
Strong evidence for a crude association between shift work exposure and body weight increase was found and more and better high quality studies about this subject are necessary.
SLEEPNocturnal Cortisol Release in Relation to Sleep Structure
187 Citations1992M. Follénius, G. Brandenberger +3 more
Analysis of the nocturnal cortisol profiles and the concomitant patterns of sleep stage distribution indicates that the cortisol profile is not influenced by sleep deprivation, and tends to imply that cortisol-releasing mechanisms may be involved in the regulation of sleep.
The Journal of Clinical Endocrinology & MetabolismInfluences of Corticotropin-Releasing Hormone, Adrenocorticotropin, and Cortisol on Sleep in Normal Man*
174 Citations1989Jan Born, E. Späth‐Schwalbe +3 more
Results suggest that cortisol has a sleep modulatory effect, and ACTH specifically altered sleep, in that it inhibited the cortisol-induced increase in SWS and peripherally administered CRH had no intrinsic influence on sleep.
British Journal Of NutritionEffects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men
168 Citations2012Hanne K. J. Gonnissen, Rick Hursel +3 more
A single night of fragmented sleep, resulting in reduced REM sleep, induced a shift in insulin concentrations, from being lower in the morning and higher in the afternoon, while GLP-1 concentrations and fullness scores were decreased, which may lead to increased food intake and snacking, thus contributing to a positive energy balance.
Respiratory MedicinePituitary reactivity, androgens and catecholamines in obstructive sleep apnoea. Effects of continuous positive airway pressure treatment (CPAP)
167 Citations1999T. Bratel, A Wennlund +1 more
There was a significant correlation between low pretreatment nocturnal arterial oxygen saturation and high plasma and urinary norepinephrine levels and the nCPAP treatment caused significant reduction in serum prolactin and TSH, andsignificant reduction in plasma epinephrine and urinarynorepine serotonin levels.
American Journal of Physiology-Endocrinology and MetabolismGluco- and antimineralocorticoid effects on human sleep: a role of central corticosteroid receptors
162 Citations1991Jan Born, E. R. DeKloet +3 more
The results suggest that corticosteroid-induced changes in SWS are mediated via MR-like central receptors in humans, whereas changes in REM sleep involve GR.
EndocrinologyEvidence for Mineralocorticoid Receptor Facilitation of Glucocorticoid Receptor-Dependent Regulation of Hypothalamic-Pituitary-Adrenal Axis Activity*
161 Citations1998Robert L. Spencer, Paul J. Kim +2 more
Physiology & BehaviorEffect of Restraint Stress on Feeding Behavior of Rats
143 Citations1997Daniela Roesch Ely, V. D Dapper +8 more
The chronic stress increases appetite for sweet food, independently of hunger, and diazepam is able to reverse this behavior.
NatureAcute Effect of a Glucocorticoid on Normal Human Sleep
134 Citations1972J. Christian Gillin, L S Jacobs +2 more
The effect of a glucocorticoid on normal human sleep is determined to determine the level of elevation in adrenal cortical steroid secretion in psychiatric patients.
The Journal of Clinical Endocrinology & MetabolismHypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy
130 Citations2007Alexandros N. Vgontzas, S. Pejovic +7 more
The cortisol secretion was slightly activated by SA and returned to low by CPAP use, suggesting that the low cortisol secretion in obesity through its inferred hyposecretion of hypothalamic CRH might predispose the obese to sleep apnea.
Journal of Sleep ResearchLeptin and hunger levels in young healthy adults after one night of sleep loss
130 Citations2010Slobodanka Pejovic, Alexandros N. Vgontzas +8 more
AppetiteStress response and binge eating disorder
128 Citations2005Marci E. Gluck
A theoretical overview of how cortisol secretion, a major component of the stress response, could play a role in binge eating, given that exogenous glucocorticoids can lead to obesity by increasing food intake.
PubMedNeuroendocrine dysregulation in primary insomnia.
124 Citations2001Andrea Rodenbeck, Göran Hajak
A model of HPA dysregulation in insomnia is proposed based on the arousal theory of insomnia and the strong correlation between evening cortisol secretion and sleep fragmentation as a pathophysiological mechanism of a vicious cycle of insomnia.
SLEEPBody Mass Index-Independent Metabolic Alterations in Narcolepsy with Cataplexy
121 Citations2009Francesca Poli, Giuseppe Plazzi +8 more
BMI-independent metabolic alterations and the relative hypophagia of patients with narcolepsy with cataplexy, as compared with patients with idiopathic hypersomnia without long sleep time, suggest that orexin-A influences the etiology of this phenotype.
Journal of Sleep ResearchThe effects of leptin on REM sleep and slow wave deltain rats are reversed by food deprivation
121 Citations1999Christopher M. Sinton, Thomas Fitch +1 more
Prior food deprivation negated the effect of leptin on both REMS and SWS, a result that emphasizes the significance of the apparent coupling between sleep parameters and energy status.
Current Obesity ReportsThe Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity
118 Citations2012Eliane A. Lucassen, Giovanni Cizza
Findings implicate that obesity, stress and sleep loss are all related in a vicious circle and new strategies to combat obesity through modulating cortisol levels in adipose tissue by 11β-HSD1 inhibitors or by improving sleep duration are discussed.
Diabetes & MetabolismPrevalence and predictive factors of sleep apnoea syndrome in type 2 diabetic patients
111 Citations2009J Laaban, Simon Daenen +5 more
Journal of Diabetes and its ComplicationsLeptin
107 Citations2003Darleen A. Sandoval, Stephen N. Davis
The purpose of this review to is critically analyze the literature regarding the impact of different types of stress on leptin secretion, the function of leptin during stress, and the role of leptin in the pathophysiology of diabetes.
SLEEPHigh Prevalence of Eating Disorders in Narcolepsy with Cataplexy: A Case-Control Study
106 Citations2008H.A. Droogleever Fortuyn, Sofie Swinkels +6 more
The majority of patients with narcolepsy experience a number of symptoms of eating disorders, with an irresistible craving for food and binge eating as the most prominent features.
Cell Biochemistry and FunctionShort sleep duration and obesity: mechanisms and future perspectives
105 Citations2012Ioná Zalcman Zimberg, Ana Raimunda Dâmaso +6 more
It will be discussed how sleep restriction may lead to increase in food intake and result in greater fatigue, which may favour decreased energy expenditure, and the importance of getting enough good sleep for metabolic health.
The Journal of Clinical Endocrinology & MetabolismNocturnal adrenocorticotropin and cortisol secretion depends on sleep duration and decreases in association with spontaneous awakening in the morning.
99 Citations1992E. Späth‐Schwalbe, T. Schöller +3 more
The duration of sleep and nocturnal ACTH and cortisol secretion are interrelated and the data suggest that the endogenous early morning activation of the hypothalamus-pituitary-adrenocortical system is terminated by mechanisms closely associated with awakening.
PsychoneuroendocrinologyNocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans
95 Citations2006P. Schüssler, M Uhr +6 more
The findings are in line with the hypothesis that ghrelin is a sleep-promoting factor in humans and may be involved in sleep promotion after sleep deprivation.
SLEEPAdrenocortical and Gonadal Steroids During Sleep Deprivation
95 Citations1980Torbjörn Åkerstedt, Jan Palmblad +3 more
It was concluded that the results were not consistent with the view that sleep deprivation induces an emergency reaction with increased activation, but rather that it results in lower levels of both psychological and physiological activation.
American Journal of Clinical NutritionEffects of sleep fragmentation in healthy men on energy expenditure, substrate oxidation, physical activity, and exhaustion measured over 48 h in a respiratory chamber
92 Citations2011Rick Hursel, Femke Rutters +3 more
Fragmented compared with nonfragmented sleep induced reductions in the most important sleep phases, which coincided with elevated AEE, physical activity, exhaustion, and sleepiness, which may predispose to overweight.
Obesity ReviewsChronobiology, endocrinology, and energy‐ and food‐reward homeostasis
92 Citations2013Hanne K. J. Gonnissen, T. Hulshof +1 more
A reduced sleep duration, quality sleep and rapid‐eye movement sleep affect substrate oxidation, leptin and ghrelin concentrations, sleeping metabolic rate, appetite, food reward, hypothalamic‐pituitary‐adrenal (HPA)‐axis activity, and gut‐peptide concentrations, enhancing a positive energy balance.
MetabolismHormonal appetite control is altered by shift work: a preliminary study
86 Citations2011Cibele Aparecida Crispim, Jim Waterhouse +6 more
Men working different shift schedules have lower appetites and concentrations of leptin and nonacylated and acylated ghrelin than the workers on other shifts and appetite was the lowest in those working the early morning shift.
PsychoneuroendocrinologyParadoxical sleep deprivation activates hypothalamic nuclei that regulate food intake and stress response
84 Citations2009Milene de Oliveira Lara Galvão, Rita Sinigaglia‐Coimbra +3 more
Results indicate that augmented ORX and CRH immunoreactivity in specific hypothalamic nuclei may underlie some of the metabolic changes consistently described in PSD.
The Journal of Clinical Endocrinology & MetabolismDietary Macronutrient Content Alters Cortisol Metabolism Independently of Body Weight Changes in Obese Men
84 Citations2007Roland H. Stimson, Alexandra M. Johnstone +6 more
In obese men, a low-carbohydrate diet alters cortisol metabolism independently of weight loss and enhances cortisol regeneration by 11beta-HSD1 and reduces cortisol inactivation by A-ring reductases in liver without affecting sc adipose 11 beta- HSD1.
European Journal of Applied PhysiologySleep patterns in Spanish adolescents: associations with TV watching and leisure-time physical activity
83 Citations2010Francisco B. Ortega, Palma Chillón +7 more
It is concluded that non-participation in LT-PA is associated with morning tiredness in male and female adolescents, while excessive TV watching is more associated with short sleep ormorning tiredness depending on gender.
The Journal of Steroid Biochemistry and Molecular BiologySex steroids and leptin regulate 11β-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities
82 Citations2006Marie‐Noëlle Dieudonné, Anes Sammari +4 more
The findings suggest that sex steroids and leptin either increase or decrease local cortisol and estrogens productions in men or in women preadipocytes, respectively, and indicate that steroid metabolism in adipose tissue is controlled by a coordinated regulation of P450 aromatase and HSD1 expressions.
Clinical EndocrinologyCortisol levels and measures of body composition in middle‐aged and older men
80 Citations2007Thomas G. Travison, Amy B. O’Donnell +3 more
An analysis to determine both cross‐sectional and longitudinal associations between body composition and serum cortisol concentrations in a randomly chosen group of 999 community‐dwelling men, aged 40–79 years finds similarities in the symptomatic expressions of excess adiposity and hypercortisolaemic conditions suggest that elevated glucocorticoid exposure may influence the pathogenesis of obesity.
Lipids in Health and DiseaseHigh-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations
79 Citations2011Cristiane de Oliveira, Ana BM de Mattos +4 more
Hyperglycemia as a result of a high-fat diet is associated with an increase in the expression of the adiponectin receptors in muscle, and an excess of glucocorticoids, rather than their absence, increase glucose and insulin and decrease adiponectomy levels.
Nutrition Research ReviewsThe influence of sleep and sleep loss upon food intake and metabolism
78 Citations2007Cibele Aparecida Crispim, Ioná Zalcman +6 more
It is concluded that sleep loss represents an important risk factor for weight gain, insulin resistance, type 2 diabetes and dyslipidaemia, and an adequate sleep pattern is fundamental for the nutritional balance of the body and should be encouraged by professionals in the area.
Pharmacology Biochemistry and BehaviorFurther definition of the effect of corticosterone on the sleep–wake pattern in the male rat
71 Citations2001Gonzalo Vázquez-Palacios, Socorro Retana‐Márquez +2 more
Data indicate that corticosterone exerts an alerting effect that could be important in the initial stage of the stress response in rats.
Clinical EndocrinologyCortisol secretary pattern and glucocorticoid feedback sensitivity in women from a Mediterranean area: relationship with anthropometric characteristics, dietary intake and plasma fatty acid profile
70 Citations2006M. D. García‐Prieto, Francisco Javier Tébar +4 more
This work has shown that chronic stress is associated with a dysfunctional hypothalamic‐pituitary‐adrenal (HPA) axis consisting on disturbances on the cortisol response and lipid metabolism.
Sleep Medicine ReviewsIs obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence
69 Citations2012Lianne Tomfohr‐Madsen, Kate M. Edwards +1 more
The available studies do not provide clear evidence that OSA is associated with alterations in cortisol levels or that treatment with CPAP changes cortisol levels and methodological concerns such as infrequent sampling, failure to match comparison groups on demographic factors known to impact cortisol levels, and inconsistent control of variables known to influence HPA function may have limited the results.
…