Reduced Brain Norepinephrine and Dopamine Release in Treatment-Refractory Depressive Illness
Archives of General PsychiatryPublished 1 August 2000
Gavin Lambert, Mats Johansson, Hans Ågren, Peter Friberg
Citations296
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TL;DR
In accordance with the monoamine hypothesis, a deficit in brain norepinephrine and dopamine exists in patients with depressive illness and the brains of these patients use an energy source other than glucose, a situation that is normalized following the acute pharmacological blockade of the norpinephrine transporter with the tricyclic antidepressant, desipramine.
Abstract
In accordance with the monoamine hypothesis, a deficit in brain norepinephrine and dopamine exists in patients with depressive illness. Moreover, the brains of these patients use an energy source other than glucose, a situation that is normalized following the acute pharmacological blockade of the norepinephrine transporter with the tricyclic antidepressant, desipramine.
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MedicineNeuroscience
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