Dopamine and depression: A review of recent evidence. II. Theoretical approaches
Brain Research ReviewsPublished 1 December 1983
Paul Willner
Citations112
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TL;DR
The meso-limbic and nigrostriatal DA system appears to be related primarily to responsiveness to the environment, and the role of dopamine (DA) in their related animal models is discussed.
Abstract
This paper discusses 3 behavioural approaches to depression, 'learned helplessness', reward system dysfunction and reduced responsiveness to the environment, and the role of dopamine (DA) in their related animal models. The meso-limbic and nigrostriatal DA system appears to be related primarily to responsiveness to the environment. This conclusion is discussed in relation to the clinical symptomatology of depression.
Keywords
PsychologyMedicineNeuroscience
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