Direkte katalytische asymmetrische Kabachnik‐Fields‐ Dreikomponentenreaktion
Angewandte ChemiePublished 2 June 2008
Xu Cheng, Richard Goddard, Gernot Buth, Benjamin List
Citations40
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Abstract
Als α-Aminosäuremimetika sind α-Aminophosphonate sehr vielversprechende Motive für antibakterielle und Anti-HIV-Wirkstoffe sowie für Proteaseinhibitoren. Racemische α-verzweigte Aldehyde werden in Gegenwart des neuen chiralen Phosphorsäure-Katalysators 1 mit p-Anisidin (PMPNH2) und einem Phosphit direkt hoch diastereo- und enantioselektiv zu β-verzweigten α-Aminophosphonaten umgesetzt. Anth=Anthracenyl.
Keywords
Chemistry
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