Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology
The LancetPublished 1 December 1997
Anthony J. Swerdlow, Bianca De Stavola, MA Swanwick, NES Maconochie
Citations209
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
The higher risks of these cancers in dizygotic than in monozygotic twins support a prenatalAetiology, and are compatible with aetiology related to raised maternal concentrations of free, unbound oestrogens.
Abstract
The higher risks of these cancers in dizygotic than in monozygotic twins support a prenatal aetiology, and are compatible with aetiology related to raised maternal concentrations of free, unbound oestrogens. The results for twins of probands have implications for genetic aetiology; appropriate clinical action for monozygotic twins needs consideration.
Keywords
Medicine
Statistical Methods in Cancer Research
6,727 Citations1980N. E. Breslow
New England Journal of MedicineAdenocarcinoma of the Vagina
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1,725 Citations1983
PubMedBreast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.
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PubMedEstimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.
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The existing empirical data seem to be compatible with the hypothesis that increased concentrations of oestrogens in pregnancy increase the probability of future occurrence of breast cancer in daughters.
New England Journal of MedicineConcordance for Hodgkin's Disease in Identical Twins Suggesting Genetic Susceptibility to the Young-Adult Form of the Disease
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216 Citations1992D Forman, R.T.D. Oliver +6 more
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New England Journal of MedicineThe Study of Human Twins in Medical Research
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JNCI Journal of the National Cancer InstituteAn Epidemiologic Study of Breast Cancer2
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