Chiral Brønsted acid catalyzed Friedel–Crafts alkylation reactions
Chemical Society ReviewsPublished 1 January 2009
Shu‐Li You, Quan Cai, Mi Zeng
Citations757
SJR quartileQ1
SJR score11.47
SNIP7.07
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TL;DR
In this tutorial review, recent progress in the development of chiral Brønsted acid-catalyzed asymmetric Friedel-Crafts reactions is presented.
Abstract
The asymmetric Friedel-Crafts reaction is one of the most powerful methods to synthesize optically active aromatic compounds. Particularly, the Friedel-Crafts alkylation of arenes with unsaturated compounds activated by chiral Brønsted acids provides direct access to enantiopure aromatic derivatives with perfect atom economy. In this tutorial review, recent progress in the development of chiral Brønsted acid-catalyzed asymmetric Friedel-Crafts reactions is presented.
Keywords
Chemistry
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