The molecular pathology of Alzheimer's disease
NeuronPublished 1 April 1991
Dennis J. Selkoe
Citations2,700
SJR quartileQ1
SJR score6.75
SNIP2.95
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TL;DR
The salient features of the altered biochemistry of AD brain tissue and the possible role of these changes in the pathogenesis of this complex disease are reviewed here.
Abstract
The salient features of the altered biochemistry of AD brain tissue and the possible role of these changes in the pathogenesis of this complex disease are reviewed here
Keywords
MedicineNeuroscience
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461 Citations1989Tilman Oltersdorf, Lawrence C. Fritz +8 more
The deduced amino-terminal sequence of APP is iden-tical to the sequence of a cell-secreted protease inhibitor, protease nexin-II (PN-II)8, and it is concluded that the secreted form of APP with the Kunitz protease inhibitors domain is PN-II.
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesImmune System Response in Alzheimer'sDisease
461 Citations1989Patrick L. McGeer, Haruhiko Akiyama +2 more
It is established that astrocytes, which are GFAP positive, do not express MHC antigens in Alzheimer's disease, and that reactive microglia and some leukocytes express class II antigen.
NatureAmyloid β-protein deposition in tissues other than brain in Alzheimer's disease
458 Citations1989Catharine Joachim, Hiroshi Mori +1 more
The detection of amyloid beta-protein deposits in non-neural tissues and blood vessels of Alzheimer's disease patients, including skin, subcutaneous tissue and intestine is reported, indicating that a principal feature of the disease process is expressed subclinically in tissues other than brain.
Journal of Neuropathology & Experimental NeurologyFrontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau
454 Citations1999Orso Bugiani, Jill R. Murrell +14 more
One individual presented with frontotemporal dementia, whereas his son has corticobasal degeneration, demonstrating that the same primary gene defect in tau can lead to 2 distinct clinical phenotypes.
Acta NeuropathologicaImmunoglobulins and complement factors in senile plaques
452 Citations1982Piet Eikelenboom, Frank Stam
Immunoperoxidase techniques were used to obtain information about the possible presence of serum factors in senile plaques and only in plaques consisting of an amyloid core surrounded by a corona of degenerating neurites small amounts of IgG and light chains were found.
Journal of NeurochemistryIsolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease
446 Citations1986Dennis J. Selkoe, Carmela R. Abraham +2 more
Current evidence suggests that such protein(s) found in PHF‐enriched fractions may derive from copurifying amyloid filament srather than from PHF, and that extraneuronal amyloids plaque filaments in Alzheimer's disease are composed of hydrophobic low‐Mr protein which are also present in vascular amyloidal deposits.
NatureProtease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor
443 Citations1989William E. Van Nostrand, Steven L. Wagner +6 more
The regulation of extracellular proteolysis by PN-II and the deposition of at least parts of the molecule in senile plaques is consistent with previous reports that implicate altered proteolytic activity in the pathogenesis of Alzheimer's disease.
The EMBO JournalAlzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
441 Citations1988Brenda D. Shivers, C. Hilbich +4 more
Using in situ hybridization and immunocytochemistry on rat brain sections, it is discovered that rat amyloidogenic glycoprotein (rAG) and its mRNA are ubiquitously and abundantly expressed in neurons indicating a neuronal original for the amyloids deposits observed in humans with Alzheimer's disease (AD).
Proceedings of the National Academy of SciencesNeuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.
440 Citations1985C W Wong, Vito Quaranta +1 more
It is suggested that the amyloid in neuritic plaques shares antigenic determinants with beta protein of cerebral vessels and this possibility suggests a model for the pathogenesis of Alzheimer disease involving beta protein.
The American Journal of Human GeneticsHigh Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands
428 Citations1999Patrizia Rizzu, John C. van Swieten +11 more
The frequency of tau mutations in a large population-based study of FTD carried out in the Netherlands from January 1994 to June 1998 is reported, finding an intronic mutation at position +33 after exon 9, which is likely to affect the alternative splicing of t Tau.
Neuroscience LettersOccurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
428 Citations1986Heiko Braak, Eva Braak +2 more
Paired helical filaments, pathologically changed components of the cytoskeleton of human nerve cells, are demonstrated by a specific silver staining technique, immunostaining and electron microscopy.
PubMedThe presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.
421 Citations1988Alan D. Snow, H Mar +6 more
The current study identifies a new component (HSPGs) present in the amyloid deposits of NPs and CA but also suggests that astrocytes, neurons, or both may be involved in its deposition at these sites.
BMJNeurochemical characteristics of early and late onset types of Alzheimer's disease.
416 Citations1984Martin N. Rossor, L L Iversen +3 more
The results suggest that Alzheimer's disease in people aged under 80 may represent a distinct form of presenile dementia which differs in important respects from the dementia of old age.
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