On Network Theory and H-2 Restriction

A more extensive review of the data relevant to the network hypothesis of Jerne is presented, and a number of phenomena are discussed within the framework of the theory that were not previously treated.

Abstract

The network hypothesis of Jerne (1974a,b, 1976) is based on the fact that the V (variable) regions of antibody molecules can function as antigens. Such antibodies can therefore stimulate and/or suppress responses of cells that have receptors which specifically recognize these V regions. One network model that incorporates this postulate is the "plus-minus network theory" (Hoffmann, 1975, 1978). In this paper a more extensive review of the data relevant to the theory is presented, and a number of phenomena are discussed within the framework of the theory that were not previously treated. These phenomena include the subclasses of T cells and H-2 restriction.