Pain can kill
PainPublished 1 January 1991
John C. Liebeskind
Citations176
SJR quartileQ1
SJR score2.02
SNIP1.87
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TL;DR
The results in tumor-bearing rats suggest that proper management of acute pain may have special importance for patients with cancer, and it is not only safe to use analgesic drugs for controlling cancer pain in man, it may be unsafe not to.
Abstract
Pain: January 1991 - Volume 44 - Issue 1 - p 3-4 doi: 10.1016/0304-3959(91)90141-J
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The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms.
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Stress effects in Fischer 344 rats using a tumor model in which lung metastases of a syngeneic mammary tumor are controlled by natural killer cells support the hypothesis that stress can facilitate the metastatic process via suppression of the immune system.
Elsevier eBooksStress, Neuropeptides, and Systemic Disease
110 Citations1991
This book provides informative, authoritative, and up-to-date coverage of contemporary knowledge of the body's response to potent stressors as modulated by currently known neuropeptides.
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95 Citations1986Yehuda Shavit, Gregory W. Terman +4 more
It is reported that the morphine-induced suppression of NK activity shows tolerance after 14 daily injections, and the NK-suppressive effect of stress, however, shows neither tolerance with repetition nor cross-tolerance in morphine-tolerant rats.
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Supporting this hypothesis, it is reported that a high dose of an opiate agonist, morphine, also reduces survival of rats given the same tumor and shows tolerance after 14 daily injections.
