Sleep Apnea and Glucose Metabolism
CHEST JournalPublished 12 April 2012
Eva Lindberg, Jenny Theorell‐Haglöw, Malin Svensson, Þórarinn Gíslason, Christian Berne, Christer Janson
Citations161
SJR quartileQ1
SJR score1.83
SNIP1.83
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
SDB is independently related to the development of insulin resistance and, thereby, the risk of manifest diabetes mellitus and, when excluding the variable years with CPAP from the multivariate model, all associations weakened.
Abstract
SDB is independently related to the development of insulin resistance and, thereby, the risk of manifest diabetes mellitus.
Keywords
MedicineNeuroscience
DiabetologiaHomeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
31,449 Citations1985David R. Matthews, J P Hosker +4 more
The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Diabetes CareInsulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
5,647 Citations1999Masafumi Matsuda, Ralph A. DeFronzo
A novel estimate of insulin sensitivity that is simple to calculate and provides a reasonable approximation of whole-body insulin sensitivity from the oral glucose tolerance test (OGTT).
New England Journal of MedicineProspective Study of the Association between Sleep-Disordered Breathing and Hypertension
4,975 Citations2000Paul E. Peppard, Terry Young +2 more
A dose-response association between sleep-disordered breathing at base line and the presence of hypertension four years later was found that was independent of known confounding factors and suggest that sleep- disordered breathing is likely to be a risk factor for hypertension and consequent cardiovascular morbidity in the general population.
The LancetLong-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
4,651 Citations2005José M. Marı́n, Santiago Carrizo +2 more
The LancetImpact of sleep debt on metabolic and endocrine function
3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
DiabetologiaAdvanced glycation end-products: a review
2,533 Citations2001Ravinder Singh, Anne Barden +2 more
The chemistry of advanced glycated end-product formation and their patho-biochemistry particularly in relation to the diabetic microvascular complications of retinopathy, neuropathy and nephropathy as well as their role in the accelerated vasculopathy observed in diabetes are discussed.
The LancetLong-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
1,861 Citations2005José M. Marı́n, Santiago Carrizo +2 more
New England Journal of MedicineHypertension and Associated Metabolic Abnormalities — The Role of Insulin Resistance and the Sympathoadrenal System
1,446 Citations1996Gerald M. Reaven, Hans Lithell +1 more
It is hypothesized that the metabolic abnormalities linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts influence on blood pressure and complications in many patients.
American Journal of Respiratory and Critical Care MedicineObstructive Sleep Apnea Is Independently Associated with Insulin Resistance
1,307 Citations2002Msm Ip, Bing Lam +4 more
The findings suggest that OSA is independently associated with insulin resistance, and its role in the atherogenic potential of sleep disordered breathing is worthy of further exploration.
The Journal of Clinical Endocrinology & MetabolismSleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia
1,159 Citations2000Alexandros N. Vgontzas, Dimitris A. Papanicolaou +6 more
There is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition.
American Journal of EpidemiologySleep-Disordered Breathing, Glucose Intolerance, and Insulin Resistance: The Sleep Heart Health Study
1,103 Citations2004N.M. Punjabi
The results of this study suggest that sleep-disordered breathing is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus.
Annals of the New York Academy of Sciences<i>Associations between Sleep Loss and Increased Risk of Obesity and Diabetes</i>
803 Citations2008Kristen L. Knutson, Eve Van Cauter
Evidence is rapidly accumulating to indicate that chronic partial sleep loss may increase the risk of obesity and diabetes, and multiple epidemiologic studies have shown an association between short sleep and higher body mass index after controlling for a variety of possible confounders.
American Journal of Respiratory and Critical Care MedicineAssociation of Sleep Apnea and Type II Diabetes
774 Citations2005Kevin J. Reichmuth, Diane Austin +2 more
Investigating the prevalence and incidence of type II diabetes in subjects with SDB found diabetes is more prevalent in SDB and this relationship is independent of other risk factors, however, it is not clear that SDB is causal in the development of diabetes.
American Journal of Respiratory and Critical Care MedicineIncreased Adhesion Molecules Expression and Production of Reactive Oxygen Species in Leukocytes of Sleep Apnea Patients
742 Citations2002Larissa Dyugovskaya, Peretz Lavie +1 more
It is found that OSA was associated with increased expression of adhesion molecules CD15 and CD11c on monocytes, increased adherence of monocytes in culture to human endothelial cells, increased intracellular ROS production in some monocyte and granulocyte subpopulations, and upregulation of CD15 expression due to hypoxia in vitro in monocytes of control subjects.
American Journal of Respiratory and Critical Care MedicineContinuous Positive Airway Pressure Treatment Rapidly Improves Insulin Sensitivity in Patients with Obstructive Sleep Apnea Syndrome
602 Citations2003Igor Alexander Harsch, Simin Pour Schahin +9 more
The improved insulin sensitivity after 2 nights of treatment may reflect a decreasing sympathetic activity, indicating that sleep apnea is an independent risk factor for increased insulin resistance.
American Journal of Respiratory and Critical Care MedicineImpact of Untreated Obstructive Sleep Apnea on Glucose Control in Type 2 Diabetes
452 Citations2009Renee S. Aronsohn, Harry Whitmore +2 more
In patients with type 2 diabetes, increasing severity of OSA is associated with poorer glucose control, independent of adiposity and other confounders, with effect sizes comparable to those of widely used hypoglycemic drugs.
ThoraxEffect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes
407 Citations2007Sophie West, Debby Nicoll +3 more
Therapeutic CPAP does not significantly improve measures of glycaemic control or insulin resistance in men with type 2 diabetes and OSA.
The American Journal of MedicineObstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes
387 Citations2009Nader Botros, John Concato +4 more
Sleep apnea increases the risk of developing diabetes, independent of other risk factors, and among patients with more severe sleep apnea, regular positive airway pressure use may attenuate this risk.
European Respiratory JournalSleep, sleep-disordered breathing and metabolic consequences
337 Citations2009Patrick Lévy, Maria R. Bonsignore +1 more
The relative role of obesity and OSA in the pathogenesis of metabolic alterations is still unclear and is intensively studied in clinical and experimental models.
American Journal of EpidemiologySnoring as a Risk Factor for Type II Diabetes Mellitus: A Prospective Study
329 Citations2002Wael K. Al‐Delaimy, JoAnn E. Manson +3 more
It is suggested that snoring is independently associated with elevated risk of type II diabetes.
European Respiratory JournalCardiovascular and metabolic effects of CPAP in obese males with OSA
315 Citations2007Steven Coughlin, Lynn Mawdsley +3 more
In obese Caucasians with untreated obstructive sleep apnoea, continuous positive airways pressure can improve baroreceptor responsiveness and reduce waking blood pressure within 6 weeks, but this treatment period was insufficient to modify insulin resistance or change the metabolic profile.
American Journal of Respiratory and Critical Care MedicineAlterations in Glucose Disposal in Sleep-disordered Breathing
309 Citations2008Naresh M. Punjabi, Brock A. Beamer
The results of this study suggest that, independent of adiposity, SDB is associated with impairments in insulin sensitivity, glucose effectiveness, and pancreatic beta-cell function that may increase the risk of glucose intolerance and type 2 diabetes mellitus in SDB.
Journal of Internal MedicineSleep‐disordered breathing and glucose metabolism in hypertensive men: a population‐based study
292 Citations2001Ahmed Elmasry, Elisabeth Lindberg +5 more
Sleep‐disordered breathing and glucose metabolism in hypertensive men: a population‐based study.
CHEST JournalEffects of Continuous Positive Airway Pressure on Cardiovascular Risk Profile in Patients With Severe Obstructive Sleep Apnea and Metabolic Syndrome
282 Citations2008Zuzana Dorková, Darina Petrášová +3 more
In patients with severe OSA and metabolic syndrome, good compliance to CPAP may improve insulin sensitivity, reduce systemic inflammation and oxidative stress, and reduce the global CVD risk.
DiabetesHypoxia Decreases Insulin Signaling Pathways in Adipocytes
280 Citations2008Claire Regazzetti, Pascal Peraldi +8 more
Hypoxia creates a state of insulin resistance in adipocytes that is dependent upon HIF transcription factor expression and could be envisioned as a new mechanism that participates in insulin Resistance in adipose tissue of obese patients.
CHEST JournalMeasurement of Sleep-related Breathing Disturbances in Epidemiologic Studies
207 Citations1991Susan Redline, Tor D. Tosteson +2 more
Journal of Clinical Sleep MedicineIs Sleep Apnea an Independent Risk Factor for Prevalent and Incident Diabetes in the Busselton Health Study?
203 Citations2009Nathaniel S. Marshall, Keith Wong +4 more
Moderate-severe sleep apnea was a significant risk factor for incident diabetes in this Australian population-based cohort, however, the confidence intervals were wide and meta-analyses or studies with greater power will be required to verify the relationship betweenSleep apnea and the incidence of diabetes in community-based populations.
Journal of Internal MedicineThe role of habitual snoring and obesity in the development of diabetes: a 10‐year follow‐up study in a male population
195 Citations2000Ahmed Elmasry, Christer Janson +4 more
The role of habitual snoring and obesity in the development of diabetes and a 10‐year follow-up study in a male population suggests that snoring is a risk factor for diabetes.
The Journal of PhysiologyMetabolic effects of interleukin‐6 in human splanchnic and adipose tissue
152 Citations2002Dorthe Lyngsø, Lene Simonsen +1 more
It is concluded that IL‐6 elicits lipolytic effects in human adipose tissue in vivo, and thatIL‐6 also has effects on the splanchnic lipid and carbohydrate metabolism.
ThoraxPrevalence of sleep apnoea and snoring in hypertensive men: a population based study
144 Citations2002C. David Sjöström
SDB is more prevalent in men with HT than in controls and the results indicate that the influence of SDB on HT is more pronounced in younger and middle aged men than in those above 60 years.
DiabetologiaNocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS)
139 Citations2009for the CIRCS Investigators, Isao Muraki +11 more
Nocturnal intermittent hypoxia was associated with increased risk of developing type 2 diabetes among middle-aged Japanese and was also associated with decreased risk of obstructive sleep apnoea among women.
American Journal of Physiology-Endocrinology and MetabolismEndocrine responses to acute and chronic high-altitude exposure (4,300 meters): modulating effects of caloric restriction
126 Citations2005Kimberly E. Barnholt, Andrew R. Hoffman +8 more
The data suggest that hypoxia tends to increase blood hormone concentrations, but anorexia suppresses elements of the endocrine response, which results in the preservation of energy stores but may sacrifice the facilitation of oxygen delivery and the use of oxygen-efficient fuels.
Journal of Applied PhysiologyWomen at altitude: short-term exposure to hypoxia and/or α<sub>1</sub>-adrenergic blockade reduces insulin sensitivity
100 Citations2001Barry Braun, Paul Rock +7 more
European Respiratory JournalObstructive sleep apnoea is associated with decreased insulin sensitivity in females
82 Citations2008Jenny Theorell‐Haglöw, Christian Berne +2 more
Nocturnal minimal saturation was independently associated with decreased insulin sensitivity when controlling for age, waist/hip ratio, level of physical activity, smoking and alcohol consumption and when adjusting for confounders.
PubMedChronic intermittent hypoxia from pedo-stage decreases glucose transporter 4 expression in adipose tissue and causes insulin resistance.
22 Citations2010Lin Chen, Zhaolong Cao +3 more
CIH in young rats could induce insulin resistance via adverse effects on glycometabolism and emphasize the importance of early detection and treatment of insulin insensitivity in obese childhood OSA.
