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Prescriptions for chronic high-dose cyclooxygenase-2 inhibitors are often inappropriate and potentially dangerous

Journal of General Internal MedicinePublished 29 September 2005Open access
Christianne L. Roumie, Patrick G. Arbogast, Edward F. Mitchel, Marie R. Griffin
Citations21
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TL;DR

A substantial portion of coxib prescriptions were for a month’s supply at doses above those recommended for most chronic indications, and new users were also prescribed high doses despite evidence for cardiovascular comorbidity.

Abstract

A substantial portion of coxib prescriptions were for a month's supply at doses above those recommended for most chronic indications. New users were also prescribed high doses despite evidence for cardiovascular comorbidity. These prescribing patterns at doses outside licensed indications are both inappropriate and potentially dangerous.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology