<i>syn</i>‐Selective Asymmetric Mannich Reaction of Sulfonyl Imines with Iminoesters Catalyzed by the <i>N</i>,<i>N</i>,<i>N</i>‐Tridentate Bis(imidazolidine)pyridine (PyBidine)–Cu(OTf)<sub>2</sub> Complex
Chemistry - A European JournalPublished 24 July 2012Open access
Takayoshi Arai, Asami Mishiro, Eri Matsumura, Atsuko Awata, Mayu Shirasugi
Citations44
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Abstract
Chiral ligand: The [PyBidine–Cu(OTf)2] (Tf=trifluoromethanesulfonate) complex catalyzed the asymmetric Mannich reaction of sulfonyl imines and iminoesters to give the products in a high syn-selective manner. For both 4-toluene (Ts)- and 4-nitrophenylsulfonyl (Ns)-imines, the syn-adducts were obtained in up to 99 % ee (see scheme).
Keywords
Chemistry
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