Permeation Properties of Neurotransmitter Transporters
The Annual Review of Pharmacology and ToxicologyPublished 1 April 1994
H A Lester, Sela Mager, Michael W. Quick, Janis L. Corey
Citations140
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SJR score4.03
SNIP3.04
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TL;DR
The neurotransmitter transporters belong to three known families of intrinsic membrane proteins and the energy for transport, which is often against the neurotransmitter concentration gradient, is derived from the cotransport of inorganic ions.
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Since the spread of tobacco from the Americas hundreds of years ago, tobacco cigarettes and, more recently, alternative tobacco products have become global products of nicotine addiction. Within the evolving alternative tobacco product space, electronic ...Read More
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Journal of Biological ChemistryThe serotonin transporter-imipramine "receptor".
95 Citations1983Jane Talvenheimo, H Fishkes +2 more
The results suggest that serotonin and imipramine bind either to the same site or to mutually exclusive sites, but maximal imipramsine binding requires two sodium ions, while maximal serotonin binding and translocation requires only one.
Journal of Biological ChemistryThe role of chloride ion in platelet serotonin transport.
93 Citations1982Pamlea J. Nelson, Gary Rudnick
Serotonin influx requires external Cl-, and efflux requires internal Cl-.
BiochemistryEnergetics of reserpine binding and occlusion by the chromaffin granule biogenic amine transporter
88 Citations1990Gary Rudnick, Sonia Steiner‐Mordoch +3 more
The results raise the possibility that the transporter, by translocating one H+ ion outward down its concentration gradient, is converted to a form that can either transport a neutral substrate molecule inward or occlude reserpine in a dead-end complex.
BiochemistryReserpine binding to chromaffin granules suggests the existence of two conformations of the monoamine transporter
85 Citations1989François Darchen, Daniel Scherman +1 more
It is proposed that the transporter exists in two different conformations which bind exclusively either tetrabenazine (TBZ) or RES and which are in equilibrium, and that RES stabilizes the RES-binding conformation, allowing its solubilization by this detergent.
Journal of Biological ChemistryReserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts.
85 Citations1993Shimon Schuldiner, Yahui Liu +1 more
It is shown that reserpine binds specifically and quantitatively to CGAT, the principal inhibitor of vesicular amine transport, and 1-methyl-4-phenylpyridinium and tetrabenazine compete very poorly with Reserpine for binding, suggesting that they interact with CGAT at distinct sites.
Journal of NeurochemistryAllosteric Interaction Between the Site Labeled by [<sup>3</sup>H]Imipramine and the Serotonin Transporter in Human Platelets
84 Citations1987Laurence R. Meyerson, John R. Ieni +1 more
Results reported herein support the notion of an allosteric interaction between the [3H]IMI binding site and the 5‐HT transporter complex in human platelets.
FEBS LettersA human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies <i>Taq</i>I RFLPs
83 Citations1993Christopher K. Surratt, Antonio M. Persico +8 more
The cDNA, and a subclone, recognize TaqI polymorphisms that may prove useful to assess this gene's involvement in neuropsychiatric disorders involving monoaminergic brain systems.
European Journal of NeuroscienceGlutamate Toxicity: An Experimental and Theoretical Analysis
83 Citations1992G. Garthwaite, G. Williams +1 more
NeuronA fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo
82 Citations1993Dieter Bruns, Florian Engert +1 more
The results demonstrate that reuptake activates with a minimal delay of less than a millisecond during synaptic transmission and acts as a rapid transmitter removal system to determine the time course of the postsynaptic response and monitors the kinetics of transmitter clearance at the synaptic site.
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