A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.
The EMBO JournalPublished 1 January 1988Open access
Philippe Chavrier, Marino Zerial, Patrick Lemaire, José M. Almendral, R Bravo, Patrick Charnay
Citations429
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TL;DR
Mechanisms suggest that Krox‐20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation,possibly involved inThe modulation ofcell proliferation.
Abstract
Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation.
Keywords
Biochemistry, Genetics and Molecular Biology
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