Regulation of GATA gene expression during vertebrate development
Seminars in Cell and Developmental BiologyPublished 14 December 2004
John B.E. Burch
Citations122
SJR quartileQ1
SJR score2.62
SNIP1.59
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Abstract
GATA factors regulate critical events in hematopoietic lineages (GATA-1/2/3), the heart and gut (GATA-4/5/6) and various other tissues. Transgenic approaches have revealed that GATA genes are regulated in a modular fashion by sets of enhancers that govern distinct temporal and/or spatial facets of the overall expression patterns. Efforts are underway to resolve how these GATA gene enhancers are themselves regulated in order to elucidate the genetic and molecular hierarchies that govern GATA expression in particular developmental contexts. These enhancers also afford a raft of tools that can be used to selectively perturb and probe various developmental events in transgenic animals.
Keywords
Biochemistry, Genetics and Molecular Biology
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