Usefulness and Limitations of Normal Mode Analysis in Modeling Dynamics of Biomolecular Complexes
StructurePublished 1 March 2005Open access
Jianpeng Ma
Citations495
SJR quartileQ1
SJR score2.01
SNIP0.98
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TL;DR
In this review, the author addresses some common issues so as to raise the awareness of the usefulness and limitations of the method in the general community of structural biology.
Abstract
Various types of large-amplitude molecular deformation are ubiquitously involved in the functions of biological macromolecules, especially supramolecular complexes. They can be very effectively analyzed by normal mode analysis with well-established procedures. However, despite its enormous success in numerous applications, certain issues related to the applications of normal mode analysis require further discussion. In this review, the author addresses some common issues so as to raise the awareness of the usefulness and limitations of the method in the general community of structural biology.
Keywords
Materials ScienceBiochemistry, Genetics and Molecular Biology
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