Fetal nutrition and cardiovascular disease in later life
British Medical BulletinPublished 1 January 1997
David J.P. Barker
Citations372
SJR quartileQ1
SJR score2.01
SNIP2.68
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Abstract
Recent finding suggest that many fetuses have to adapt to a limited supply of nutrients and in doing so they permanently change their physiology and metabolism. These 'programmed' changes may be the origins of a number of diseases in life, including coronary heart disease and the related disorders stroke, diabetes and hypertension.
Keywords
Medicine
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The LancetINFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
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The LancetFetal nutrition and cardiovascular disease in adult life
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BMJFetal and infant growth and impaired glucose tolerance at age 64.
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BMJFetal and placental size and risk of hypertension in adult life.
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BMJThe relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life.
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BMJBirth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype?
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BMJInitiation of hypertension in utero and its amplification throughout life.
648 Citations1993Catherine Law, Michael de Swiet +5 more
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HeartSocial class and coronary heart disease.
647 Citations1981G Rose, Michael Marmot
It seems that there are major risk factors yet to be identified, and that these may throw light on how it is possible for members of a highly-placed social group to have a relatively low risk of coronary heart disease.
BMJGrowth in utero and serum cholesterol concentrations in adult life.
634 Citations1993David J. Barker, C N Martyn +3 more
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BMJMaternal nutrition in early and late pregnancy in relation to placental and fetal growth
614 Citations1996Keith M. Godfrey, Siân Robinson +3 more
It is suggested that a high carbohydrate intake in early pregnancy suppresses placental growth, especially if combined with a low dairy protein intake in late pregnancy, which could have long term consequences for the offspring's risk of cardiovascular disease.
The LancetFetal growth and coronary heart disease in South India
608 Citations1996CE Stein, CHD Fall +4 more
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The LancetDysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?
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523 Citations1994Rodolfo Valdéz, M. A. Athens +3 more
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The LancetBirthweight, body-mass index in middle age, and incident coronary heart disease
514 Citations1996Stephen Frankel, P C Elwood +3 more
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BMJMother's weight in pregnancy and coronary heart disease in a cohort of finnish men: follow up study
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Proceedings of the Royal Society of London. Series B, Biological sciencesThe maternal effects on growth and conformation in shire horse-shetland pony crosses
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It is justifiable to assume, on the basis of much genetical experimentation on size inheritance, that a large number of factors would be involved, that segregation and recombination would be at random, and that the off spring of the two breeds would be genetically intermediate, irrespective of which way the cross was made.
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HeartGrowth in utero, adult blood pressure, and arterial compliance.
367 Citations1995C N Martyn, D.J.P. Barker +4 more
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The interactions of time and the environment on the growth of animals and of their organs are complex and theories that have been formulated are discussed, but none of those yet put forward explain all the facts that can be demonstrated experimentally.
Archives of Disease in ChildhoodMaternal and fetal influences on blood pressure.
269 Citations1991Catherine Law, D J Barker +2 more
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BMJRelation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life.
251 Citations1992D.J.P. Barker, T W Meade +5 more
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232 Citations1995Jane E. Harding, Barbara M. Johnston
Annals of Human GeneticsTHE INHERITANCE OF HUMAN BIRTH WEIGHT*
220 Citations1955By NEWTON E. MORTON
No significant effect of inbreeding was observed on the variance of birth weight or the correlation between sibs, but inbreeding of the foetus did appear to affect mean birth weight, 10% inbreeding being estimated to decrease birth weight by about 4·3 decagrams.
Biochemical Society TransactionsAdult glucose and lipid metabolism may be programmed during fetal life
210 Citations1995Mina Desai, Nigel J. Crowther +3 more
BJOG An International Journal of Obstetrics & GynaecologyMaternal birthweight and diet in pregnancy in relation to the infant's thinness at birth
178 Citations1997Keith M. Godfrey, David J.P. Barker +2 more
To examine how maternal diet in pregnancy and parental body size and birthweight influence an infant's thinness at birth measured by a low ponderal index, a large number of studies have looked at this topic.
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176 Citations1994David O. Kleemann, S.K. Walker +1 more
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159 Citations1989Abigail L. Fowden
Mise en evidence de la preponderance de l'insuline dans le developpement et la croissance normale du foetus humain, dans the regulation de la composition corporelle, de the croissance du squelette et des tissus foetaux.
Acta PaediatricaThe fetal origins of coronary heart disease
158 Citations1997DJP Barker
Animal studies have shown that undernutrition before birth programmes persisting changes in a range of metabolic, physiological and structural parameters are persisting and humans are beginning to understand something of the mechanisms underlying these associations.
Journal of HypertensionLow birth weight is associated with elevated systolic blood pressure in adolescence
153 Citations1997Peter M. Nilsson, Per‐Olof Östergren +3 more
Birth weight was inversely associated with SBP in a large cohort of young men in their late teens, supporting the notion of a programming effect of fetal growth retardation in utero on haemodynamic regulation in early adult life.
BJOG An International Journal of Obstetrics & GynaecologyPLACENTAL HYPERTROPHY IN SEVERE PREGNANCY ANAEMIA*
152 Citations1970Norman A. Beischer, R. Sivasamboo +3 more
A prospective combined study of consecutive patients with severe pregnancy anaemia was performed in five countries and the important finding was that placental hypertrophy was associated with maternal anaemia in all centres.
DiabetesPersistent Impairment of Insulin Secretory Response to Glucose in Adult Rats After Limited Period of Protein-Calorie Malnutrition Early in Life
132 Citations1987Ingemar Swenne, C. J. Crace +1 more
It is concluded that protein-calorie malnutrition early in life persistently impairs the insulin secretion, and the persistently lowered protein/DNA ratios in many tissues may be related to this lowered capacity for insulin secretion.
British Journal Of NutritionThe effect of rehabilitation at different stages of development of rats marginally malnourished for ten to twelve generations
122 Citations1980R. J. C. Stewart, Hilda Sheppard +2 more
In a test designed to evaluate learning ability rehabilitated rats of groups P and F were significantly less successful than normal rats, but more successful than rats of group W or rats of the original undernourished colony.
Archives of Disease in ChildhoodDo maternal and intrauterine factors influence blood pressure in childhood?
115 Citations1992Peter H. Whincup, Derek G. Cook +1 more
Maternal age, height, and body mass index were all positively related to blood pressure in childhood but these relationships were abolished once the child's body build was taken into account, suggesting a postnatal rather than a prenatal origin.
BMJPerinatal characteristics in relation to incidence of and mortality from prostate cancer
114 Citations1996Anders Ekbom, Chung‐Cheng Hsieh +5 more
Pre-eclampsia and prematurity were associated with a reduced risk of prostate cancer and ponderal index was associated with an increased risk of mortality from prostate cancer Prenatal exposures that are likely correlates of pregnancy hormones and other growth factors seem to be of importance in the prostate carcinogenesis.
The Journal of Agricultural ScienceMaternal undernutrition during mid-pregnancy in sheep: variable effects on placental growth
113 Citations1992G. J. McCrabb, A. R. Egan +1 more
It is suggested that maternal liveweight, possibly body reserves not quantifiable by condition score, protects and even enhances placental growth during a period of maternal undernutrition.
Reproduction Fertility and DevelopmentPlacental control of fetal growth
107 Citations1995Jeffrey S. Robinson, S Chidzanja +4 more
Variations in the maternal environment and consequent perturbation of the metabolic and endocrine environment of the placenta and fetus are implicated as being responsible for the associations between prenatal growth of the placentala and its fetus and the subsequent risk of adult disease.
HeartBirth weight, weight at one year, and left ventricular mass in adult life.
107 Citations1995M Vijayakumar, Caroline Fall +2 more
Low weight at 1 year is associated with concentric enlargement of the left ventricle in adult life, consistent with a previous finding of higher mortality from cardiovascular disease in men of low weight at1 year, and provides further evidence that cardiovascular disease may be partly programmed in early life.
Obstetrics and GynecologyWeight Gain in Pregnancy, Triceps Skinfold Thickness, and Blood Pressure in Offspring
105 Citations1998P. Clark
It is suggested that fetal adaptations to poor maternal nutrition lead to elevated BP in childhood but adequate maternal weight gain during pregnancy may protect against this.
PubMedSecond-generation consequences of small-for-dates birth.
95 Citations1989Mark A. Klebanoff, Olav Meirik +1 more
BMJIs birth weight determined genetically?
91 Citations1987Roy Carr‐Hill, D. M. Campbell +2 more
It is concluded that genetic factors play only a small part in determining birth weight, after standardisation for fetal sex, maternal height, gestational age, and proteinuric pre-eclampsia.
PubMedTrends of mortality from ischaemic heart disease and other cardiovascular diseases in 27 countries, 1968-1977.
88 Citations1982Z Písa, K Uemura
Ischemic heart disease mortality trends in the 27 developed countries for which reasonably reliable statistical data are available in the World Health Organizations data base are reviewed and analysis of these data is presented in relation to mortality from all causes all cardiovascular diseases and cerebrovascular disease.
BMJAbnormal liver growth in utero and death from coronary heart disease
83 Citations1995D.J.P. Barker, C N Martyn +2 more
A recent study showed that men who had a small abdominal circumference at birth had raised serum concentrations of total and low density lipoprotein cholesterol and had raised plasma concentrations of fibrinogen, another major risk factor for coronary heart disease that is regulated by the liver.
Journal of Epidemiology & Community HealthDiet and coronary heart disease in England and Wales during and after the second world war.
82 Citations1986D.J.P. Barker, Clive Osmond
This paper re-examines CHD mortality among middle-aged people in England and Wales from 1931 to 1967 and gives no support to the view that compliance with the recommendations on fat, fibre, and sugar will lead, by itself, to an appreciable fall inCHD mortality in middle- aged people.
HypertensionWeights at Birth and in Early Infancy, Systolic Pressure, and Left Ventricular Structure in Subjects Aged 8 to 24 Years
82 Citations1996Mahmoud Zureik, Claire Bonithon‐Kopp +3 more
This study supports the hypothesis that systolic pressure and left ventricular mass might be partly determined during fetal life and early infancy and the mechanisms that underlie the associations of blood pressure andleft ventricular structure with weights at birth and in early infancy should be studied thoroughly.
Early Human DevelopmentIntrauterine feeding of the growth retarded fetus: can we help?
67 Citations1992Jane E. Harding, L. Liu +3 more
Understanding the role of the placenta in this regulation is essential if in the future the authors are to help the growth retarded fetus.
DiabetesHigh Prevalence of Diabetes in Young Adult Ethiopian Immigrants to Israel
64 Citations1988Margo P. Cohen, Ervin Stern +2 more
A high prevalence of diabetes among young adult Ethiopian immigrants of relatively short residency in Israel indicates a profound change in dietary habits since arrival in Israel, with consumption of large amounts of refined carbohydrate in place of spicy stews and injura that had constituted dietary staples in better times in Ethiopia.
DiabetologiaBirthweight and adult health outcomes in a biethnic population in the USA
51 Citations1994Rodolfo Valdéz, M. A. Athens +3 more
PubMedCellular aspects of growth and catch-up growth in the rat: a reevaluation.
50 Citations1986Pitts Gc
The effect of nutritional perturbations upon growth and catch-up growth in mass in the rat have been reevaluated by interpretation of published data and the generalizations arrived at also apply in these cases.
Effects of changes in maternal energy and protein intake during pregnancy, with special reference to fetal growth
44 Citations1989David Rush
The relationship between the diet of the mother and the wellbeing of the fetus and infant continues to be a matter of great importance, uncertainty and controversy.
The LancetWeight gain in infancy and cancer of the ovary
43 Citations1995D. J. P. Barker, P D Winter +3 more
Among 5585 women born in Hertfordshire, UK, 41 who died from ovarian cancer had had a high rate of weight gain in infancy, consistent with the hypothesis that ovarian cancer is linked to altered patterns of gonadotropin release established in utero when the fetal hypothalamus is imprinted.
BJOG An International Journal of Obstetrics & GynaecologyFetal heart rate and intrauterine growth
40 Citations1991Siân Robinson, Timothy Wheeler +3 more
To assess whether fetal heart rate in early and late pregnancy relates to size at birth, a large number of studies have looked at this topic through the second trimester of pregnancy and found no clear relationship between pregnancy size and heart rate.
The LancetRelation between maternal haemoglobin and placental hormone concentrations in early pregnancy
37 Citations1994T. Wheeler
Examination of the relation between haematological status and plasma concentrations of chorionic gonadotropin and placental lactogen in 175 women at about 10 weeks of pregnancy concluded that the observations reflect an influence of the maternal environment on the placenta.
Acta PaediatricaEarly influences on embryonic and placental growth
31 Citations1997J. S. Robinson, KM Hartwich +3 more
Growth of the placenta is influenced by events before and during early pregnancy, including maternal size and nutrition, and the local metabolic, cytokine and hormonal environment of the embryo.
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