Role of the dopaminergic system in depression
Biological PsychiatryPublished 1 July 1992
Shitij Kapur, J. John Mann
Citations349
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
Results from studies in depression, Parkinson's disease, and animal models of depression suggest a deficiency of dopamine in depression.
Abstract
A hypothesis implicating dopamine in depression was proposed over 15 years ago (Randrup et al 1975). The identification of multiple new subtypes of dopamine receptors and evolving views regarding the function of the dopamine systems in the brain require a reexamination of this hypothesis. Results from studies in depression, Parkinson's disease, and animal models of depression suggest a deficiency of dopamine in depression. Dopamine precursors, dopamine agonists, and dopamine reuptake inhibitors show therapeutic efficacy in depression. Electroconvulsive therapy (ECT) and standard pharmacological antidepressants enhance dopamine function. Studies using receptor-specific drugs in clinical trials and neuroimaging studies are needed to further clarify the role of dopamine in depression.
Keywords
MedicineNeuroscience
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17 Citations1977A. D. Forrest, A.J. HEWETT +1 more
Nomifensine was shown to be at least as effective as imipramine in relieving depression and to relieve the anxiety component of the disease significantly more rapidly.
PubMed[Polygraphic, clinical and therapeutic markers of dopamine-dependent depressions].
16 Citations1987J Mouret, Pascale Lemoine +1 more
All the patients diagnosed according to the reported polygraphic criteria were cured following a therapeutic trail with a dopamine agonist (Piribedil) and favor a role of DA in the genesis of this type of depression.
European Journal of PharmacologyRepeated treatment with imipramine decreased the number of [3H]piflutixol binding sites in the rat striatum
13 Citations1985Violetta Klimek, Mogens Brøndsted Nielsen +1 more
British Journal of Clinical PharmacologyA clinical comparison of nomifensine and amitriptyline.
13 Citations1977HA McClelland, TA Kerr +1 more
The overall frequency of side-effects was similar in the nomifensine and amitriptyline patients, But the development of severe side- effects was significantly more common in the amitripyline group.
NeuropharmacologyEffects of chronic electroconvulsive shock on D1 and D2 dopamine receptor-mediated activity of adenylate cyclase in homogenates of striatum and limbic forebrain of rat
12 Citations1989Michael E. Newman, Bernard Lerer
The selective effect of chronic electroconvulsive shock in increasing the activity of D1 receptors may account both for the increase, in dopamine-mediated behaviour, seen after chronic electro Convulsive shock and for the antiparkinsonian effects of this treatment.
NeuropharmacologyOn the mechanism of potentiation of apomorphine-induced stereotypy due to electroconvulsive shock
12 Citations1987Anil Gulati, R.C. Srimal +2 more
Alteration in the blood-brain barrier (BBB) by electroconvulsive shock leading to increased accumulation of dopamine in the corpus striatum may be responsible for the potentiation of stereotypy.
Journal of Psychiatric ResearchCerebrospinal fluid amine metabolites in affective illness
12 Citations1974FrederickK. Goodwin, RobertM. Post
is highly sensitive to fluctuations in dopaminergic activity and studies of neuroendocrine function in patients with schizophrenia and affective disorders thus offer an approach to testing the various hypotheses about altered biogenic amine metabolism in these conditions.
Clinical and Experimental Pharmacology and PhysiologyDOPAMINE RECEPTORS: CLASSIFICATION, PROPERTIES AND DRUG DEVELOPMENT
11 Citations1989Philip M. Beart
The pharmacology, biochemistry and structure‐activity relationships pertinent to the Dl and D2 subtypes of dopamine receptors are reviewed.
Trends in NeurosciencesRauwolfia and biological psychiatry
11 Citations1982H. J. Bein
It is interesting to look back on the myths that have surrounded this substance, the approaches taken in the investigation of its pharmacology, and the progress achieved.
PubMed[L-tyrosine cures, immediate and long term, dopamine-dependent depressions. Clinical and polygraphic studies].
11 Citations1988J Mouret, Pascale Lemoine +2 more
Sleep recordings performed on nights following days 1, 2, 7 and 8 of treatment showed an immediate improvement of those sleep parameters differentiating the more clearly DDD from other types of depression.
Clinical NeuropharmacologyEvaluation of the Efficacy of Amineptine in a Population of 1,229 Depressed Patients: Results of a Multicenter Study Carried Out by 135 General Practitioners
9 Citations1989M. Paes de Sousa, José Tropa
Efficacy of amineptine was very good and rapid since there was a statistically significant difference in all observations with the different instruments of measurement used; results were good in all types of depression, mainly in the neurotic and reactive ones.
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