Metabolic and Glycemic Sequelae of Sleep Disturbances in Children and Adults
Current Diabetes ReportsPublished 11 November 2014
Dorit Koren, Katie L. O’Sullivan, Babak Mokhlesi
Citations90
SJR quartileQ1
SJR score2.16
SNIP1.80
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TL;DR
Current evidence supporting the contributions that sleep disorders play in the development of obesity, insulin resistance, and T2DM as well as possibly influences on glycemic control in type 1 diabetes are reviewed, with a special focus on data in pediatric populations.
Abstract
The prevalence of obesity in adults and children has increased greatly in the past three decades, as have metabolic sequelae, such as insulin resistance and type 2 diabetes mellitus (T2DM). Sleep disturbances are increasingly recognized as contributors to this widespread epidemic in adults, and data are emerging in children as well. The categories of sleep disturbances that contribute to obesity and its glycemic co-morbidities include the following: (1) alterations of sleep duration, chronic sleep restriction and excessive sleep; (2) alterations in sleep architecture; (3) sleep fragmentation; (4) circadian rhythm disorders and disruption (i.e., shift work); and (5) obstructive sleep apnea. This article reviews current evidence supporting the contributions that these sleep disorders play in the development of obesity, insulin resistance, and T2DM as well as possibly influences on glycemic control in type 1 diabetes, with a special focus on data in pediatric populations.
Keywords
PsychologyMedicineNeuroscience
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73 Citations2010Mária Pallayová, Viliam Donič +3 more
It is suggested that polysomnographic recognition of altered sleep architecture may be partially implicated in the early detection of persons with type 2 diabetes.
Pediatric ResearchSleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males
56 Citations2012Daniel J. Lesser, Rajeev Bhatia +7 more
Sleep fragmentation and intermittent hypoxemia are associated with metabolic impairment in obese adolescent Latino males independent of age and adiposity, and it is speculated that SRBD potentiates the risk for development of metabolic syndrome and type 2 diabetes in the obese adolescent population.
American Journal of Physiology-Endocrinology and MetabolismAdrenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3T3-L1 adipocytes by inhibiting GLUT4 translocation
52 Citations2005A. H. Mulder, Cees J. Tack +4 more
Results show that beta-adrenergic (but not alpha- adrenergic) stimulation inhibits insulin-induced glucose uptake in 3T3-L1 adipocytes, most likely via the beta(2)- and beta(3)-adrenoceptor by interfering with GLUT4 translocation from intracellular vesicles to the plasma membrane.
International Journal of Pediatric OtorhinolaryngologyMetabolic alterations in children with obstructive sleep apnea
51 Citations2014Bharat Bhushan, John Maddalozzo +5 more
Metabolic alterations in glucose and insulin levels, known to be associated with obesity and increased risk for cardiovascular disease, appear to relate to the severity of OSA in young children.
International Journal of Pediatric ObesitySleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance
48 Citations2010Tamara S. Hannon, SoJung Lee +3 more
The severity of sleep-disordered breathing (as measured by apnea-hypopnea index) was positively associated with visceral adipose tissue but not with other measures of body composition, and after controlling for body mass index, the severity of Sleep-Disordered breathing was positive associated with markers of insulin resistance (homeostasis model assessment and fasting insulin).
Journal of Sleep ResearchTime in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study
45 Citations2013Nina E. Berentzen, Henriëtte A. Smit +7 more
It is considered premature to propose that improved sleep could reduce cardiovascular risk during childhood, as associations of time in bed and multiple sleep quality characteristics with cardiometabolic markers in children were small and effect sizes of the associations in girls were small.
Journal of Clinical Sleep MedicineThe Impact of Hypoxemia on Nephropathy in Extremely Obese Patients with Type 2 Diabetes Mellitus
42 Citations2014Wen B. Leong, Melissa Nolen +4 more
Apnea and hypopnea events as well as duration of nocturnal hypoxemia were inversely associated with renal function after adjusting for potential confounders, and greater vigilance is required in identifying OSA in DM patients with extreme obesity.
European Journal of Clinical NutritionIdentification of lifestyle patterns, including sleep deprivation, associated with insulin resistance in children: the Healthy Growth Study
41 Citations2014Odysseas Androutsos, George Moschonis +5 more
A lifestyle pattern of >72 min of MVPA and 5 eating occasions/day was associated with reduced likelihood of IR in children, and the pattern characterized by more time spent on moderate-to-vigorous PA and more frequent eating occasions was inversely associated with HOMA-IR.
Journal of DiabetesAssociation between sleep architecture and glucose tolerance in children and adolescents 儿童及青少年的睡眠结构与糖耐量的关系
41 Citations2014Yin Zhu, Albert Martin Li +6 more
The aim of the present study was to examine the association between sleep architecture and glucose and insulin metabolism in both normal weight and overweight/obese children and adolescents.
Diabetes CareSubjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes
36 Citations2012Antti-Jussi Pyykkönen, Bo Isomaa +5 more
Those with more frequent complaints of sleep apnea, insomnia, and daytime sleepiness were more insulin resistant, as evidenced by higher fasting insulin concentrations and insulin and glucose responses to OGTT and more frequently had high homeostasis model assessment of IR and low insulin sensitivity index values.
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