P50 Auditory Evoked Potential Suppression in Bipolar Disorder Patients With Psychotic Features and Their Unaffected Relatives
Biological PsychiatryPublished 22 November 2006
Katja Schulze, Mei‐Hua Hall, Colm McDonald, Nicolette Marshall, Muriel Walshe, Robin Murray
Citations100
SJR quartileQ1
SJR score4.68
SNIP2.24
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The results suggest that impaired P50 gating is a putative endophenotype for psychotic bipolar disorder and thus might reflect the impact of susceptibility genes across psychosis and suggest the relationship to genetic liability in bipolar disorder is unknown.
Abstract
To our knowledge, this is the first report of diminished P50 gating in unaffected relatives of psychotic bipolar disorder patients from multiply affected families. Our results suggest that impaired P50 gating is a putative endophenotype for psychotic bipolar disorder and thus might reflect the impact of susceptibility genes across psychosis.
Keywords
MedicineNeuroscience
Archives of General PsychiatryAn Inventory for Measuring Depression
38,163 Citations1961Aaron T. Beck
The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
EconometricaA Heteroskedasticity-Consistent Covariance Matrix Estimator and a Direct Test for Heteroskedasticity
26,139 Citations1980Halbert White
Clinical Psychology ReviewPsychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
11,814 Citations1988Aaron T. Beck, Robert A. Steer +1 more
American Journal of PsychiatryThe Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
5,592 Citations2003Irving I. Gottesman, Todd D. Gould
The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
BiometricsA Note on Robust Variance Estimation for Cluster‐Correlated Data
2,523 Citations2000Rick L. Williams
This brief note presents a general proof that the estimator is unbiased for cluster-correlated data regardless of the setting.
Archives of General PsychiatryThe Long-term Natural History of the Weekly Symptomatic Status of Bipolar I Disorder
2,059 Citations2002Lewis L. Judd, Hagop S. Akiskal +7 more
Overall, the symptomatic structure is primarily depressive rather than manic, and subsyndromal and minor affective symptoms predominate, and the longitudinal weekly symptomatic course of BP-I is chronic.
American Journal of PsychiatryDistinguishing Between the Validity and Utility of Psychiatric Diagnoses
1,249 Citations2002Robert Kendell, Assen Jablensky
The meaning of the terms "validity" and "utility" as they apply to psychiatric diagnoses is examined and it is important to distinguish between validity and utility in considering psychiatric diagnoses.
Archives of General PsychiatryThe Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression
1,222 Citations2003Peter McGuffin, Frühling Rijsdijk +4 more
There are substantial genetic and nonshared environmental correlations between mania and depression, but most of the genetic variance in liability to mania is specific to the manic syndrome.
Proceedings of the National Academy of SciencesLinkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
1,147 Citations1997Robert Freedman, Hilary Coon +21 more
Linkage data provide unique new evidence that the alpha 7-nicotinic receptor gene may be responsible for the inheritance of a pathophysiological aspect of the illness.
PubMedNeurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.
898 Citations1982Lawrence E. Adler, E. Pachtman +4 more
The data suggest that normally present inhibitory mechanisms are markedly reduced in schizophrenics, and may be responsible for the defects in sensory gating which are thought to be an important part of the pathophysiology of schizophrenia.
Biological PsychiatryThe Altman Self-Rating Mania Scale
832 Citations1997Edward G. Altman, Donald Hedeker +2 more
The Altman Self-Rating Mania Scale was completed during medication washout and after treatment by 22 schizophrenic, 13 schizoaffective, 36 depressed, and 34 manic patients to measure concurrent validity andvantages of the ASRM over other self-rating mania scales are discussed.
PubMedHeritability estimates for psychotic disorders: the Maudsley twin psychosis series.
796 Citations1999Alastair G. Cardno, E. Jane Marshall +13 more
A substantial genetic contribution to variance in liability was confirmed for the major diagnostic categories except Research Diagnostic Criteria depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed, but the relative contribution of genetic and common environmental factors was unclear.
Schizophrenia ResearchMismatch negativity in schizophrenia: a meta-analysis
734 Citations2005Daniel Umbricht, S. Krljes
MMN deficits are a robust feature in chronic schizophrenia and indicate abnormalities in automatic context-dependent auditory information processing and auditory sensory memory in patients, suggesting that MMN may index ongoing neuropathological changes in the auditory cortex in schizophrenia.
American Journal of PsychiatryNormalization of auditory physiology by cigarette smoking in schizophrenic patients
680 Citations1993Lawrence E. Adler, Lee Hoffer +2 more
It is suggested that cigarette smoking can transiently normalize the impairment of auditory sensory gating in schizophrenic patients.
Journal of Medical GeneticsThe genetics of schizophrenia and bipolar disorder: dissecting psychosis
573 Citations2005Nicholas Craddock, M C O’Donovan +1 more
Increasing evidence suggests an overlap in genetic susceptibility across the traditional classification systems that dichotomised psychotic disorders into schizophrenia or bipolar disorder, most notably with association findings at DAOA(G72), DISC1, and NRG1.
Schizophrenia ResearchMeta-analysis of the P300 and P50 waveforms in schizophrenia
564 Citations2004Elvira Bramon
This meta-analysis confirms the existence of ERP deficits in schizophrenia, and the magnitude of these deficits is similar to the most robust findings reported in neuroimaging and neuropsychology in schizophrenia.
Genes Brain & BehaviorPsychiatric endophenotypes and the development of valid animal models
520 Citations2005Todd D. Gould, Irving I. Gottesman
There exists a need for increased collaboration between clinicians and basic scientists, the result of which should be to improve diagnosis, classification and treatment on one end and to increase the construct relevance of model organisms on the other.
Schizophrenia ResearchA developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder
506 Citations2004Robin Murray, Pak C. Sham +4 more
A model is suggested to explain the similarities and differences between the disorders and it is proposed that, on a background of shared genetic predisposition to psychosis, schizophrenia, but not bipolar disorder, is subject to additional genes or early insults, which impair neurodevelopment, especially of the medial temporal lobe.
Archives of General PsychiatryAssociation of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia
440 Citations2002Sherry Leonard, Judith Gault +13 more
Although linkage disequilibrium with other genetic alterations cannot be excluded, the CHRNA7 core promoter variants, found in this study, may contribute to a common pathophysiologic feature of schizophrenia.
Biological PsychiatryNormalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
412 Citations1992Lawrence E. Adler, Lee Hoffer +3 more
The results are consistent with the hypothesis that nicotinic cholinergic neurotransmission may mediate a familial psychophysiological deficit in schizophrenia.
Archives of General PsychiatryDeficits in Sensory Gating in Schizophrenic Patients and Their Relatives
378 Citations1984Clifford H. Siegel
A deficit in inhibitory gating of auditory evoked responses was examined in 15 schizophrenic patients, their first-degree relatives, and normal subjects, using a conditioning-testing paradigm with the P50 wave of the auditory evokes response, finding a result that replicates the previous finding of a deficit in inhibition in schizophrenia.
Archives of General PsychiatryAssociation of Genetic Risks for Schizophrenia and Bipolar DisorderWith Specific and Generic Brain Structural Endophenotypes
375 Citations2004Colm McDonald, Edward T. Bullmore +5 more
Investigating the relationship between genetic risk and structural variation throughout the entire brain in patients and their unaffected relatives sampled from multiply affected families with schizophrenia or bipolar disorder found the 2 major psychoses show both distinctive and similar patterns of brain structural abnormality related to variable genetic risk.
American Journal of PsychiatryPoor P50 Suppression Among Schizophrenia Patients and Their First-Degree Biological Relatives
273 Citations1998Brett A. Clementz, Mark A. Geyer +1 more
This is the first demonstration independent of the group associated with the University of Colorado that schizophrenia patients' family members have poor P50 suppression, and is intrinsically important, perhaps especially because a recent report suggests genetic linkage to the cholinergic receptor's alpha7 nicotinic subunit.
Biological PsychiatrySensory gating in schizophrenics and normal controls: Effects of changing stimulation interval
256 Citations1989Herbert T. Nagamoto, Lawrence E. Adler +2 more
Although sensory gating mechanisms responsible for changes in neuronal response at longer intervals are chronically defective in schizophrenics, other gating mechanism functioning at shorter intervals appear to be intact and function well in most patients.
Schizophrenia ResearchElementary neuronal dysfunctions in schizophrenia
250 Citations1991Robert Freedman, Merilyne Waldo +2 more
An elementary deficit in sensory processing in people with schizophrenia is described, which appears to be genetically determined and to involve the brainstem control of sensory input to the hippocampus.
American Journal of PsychiatryRegional Brain Morphometry in Patients With Schizophrenia or Bipolar Disorder and Their Unaffected Relatives
225 Citations2006Colm McDonald, Nicolette Marshall +9 more
Schizophrenia and psychotic bipolar disorder are characterized by morphometric distinctions in ventricular and hippocampal regions, and lateral ventricular enlargement represents a potential morphometric endophenotype for schizophrenia.
NeuroImageIs the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
217 Citations2005Elvira Bramon, Colm McDonald +7 more
The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia.
Behavior GeneticsHeritability and Reliability of P300, P50 and Duration Mismatch Negativity
212 Citations2006Mei‐Hua Hall, Katja Schulze +7 more
The high reliability and heritability of the P300 amplitude, MMN amplitude, and P50 suppression ratio components supports their use as candidate endophenotypes for psychiatric research.
PubMedNeurophysiological studies of sensory gating in mania: comparison with schizophrenia.
207 Citations1983Franks Rd, Adler Le +3 more
The data suggest that deficits in neuronal gating functions, similar to those found in schizophrenia, can be seen during acute mania but these deficits return to normal as the acute psychosis abates.
Experimental Brain ResearchMultichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia
193 Citations2001Brett A. Clementz, Laura D. Blumenfeld
Two novel differences are suggested: (1) S1 amplitudes largely determine differences between normal and schizophrenia groups on AER suppression, and (2) frequency domain analyses may provide important complimentary information when studying AERs in schizophrenia.
American Journal of PsychiatryVaried Effects of Atypical Neuroleptics on P50 Auditory Gating in Schizophrenia Patients
193 Citations2004Lawrence E. Adler, Ann Olincy +10 more
Improvement in P50 gating appears to be greatest in patients treated with clozapine, and this study sought to determine whether other atypical neuroleptics improve P50 ratios.
PsychophysiologyReliability of P50 auditory event‐related potential indices of sensory gating
189 Citations1994David A. Smith, NASHAAT N. BOUTORS +1 more
The C - T difference score is a promising alternative to the unreliable T/C suppression ratio and theoretical consequences of changed metrics are discussed.
American Journal of PsychiatryDiminished Suppression of the P50 Auditory Evoked Potential in Bipolar Disorder Subjects With a History of Psychosis
148 Citations2004Ann Olincy, Laura Martín
A longitudinal history of psychosis in subjects with bipolar illness was associated with diminished suppression of the P50 auditory evoked potential, which may represent a common physiological mechanism associated with the vulnerability to psychosis in people withipolar illness as well as inPeople with schizophrenia.
Psychiatry ResearchSensory physiology and catecholamines in schizophrenia and mania
138 Citations1990Lawrence E. Adler, Greg A. Gerhardt +5 more
Comparisons of medicated and unmedicated states showed that schizophrenic patients have a fixed deficit in sensory gating, which is a familial trait, unchanged by medication, which may explain similarities in acute symptoms and differences in other aspects of the illnesses, such as their response to treatment.
Biological PsychiatryElementary phenotypes in the neurobiological and genetic study of schizophrenia
135 Citations1999Lawrence E. Adler, Robert Freedman +3 more
The initial study showing linkage of the P50 deficit to the chromosome 15q14 locus of the alpha 7-nicotinic acetylcholine receptor is an example of the potential usefulness of these phenotypes for combined genetic and neurobiological study of schizophrenia.
Behavior GeneticsA pilot Swedish twin study of affective illness including hospital- and population-ascertained subsamples: Results of model fitting
135 Citations1995Kenneth S. Kendler, Nancy L. Pedersen +2 more
It is suggested that in Sweden, AI is a highly heritable syndrome and family resemblance is due largely or entirely to genetic factors.
Psychiatry ResearchCodistribution of a sensory gating deficit and schizophrenia in multi-affected families
128 Citations1991Merilyne C. Waldo, Gregory Carey +8 more
A mathematical model developed is suitable for the evaluation of putative phenotypes in families to be studied by linkage analysis with polymorphic genetic markers, and suggests that the P50 defect is familially associated with schizophrenia.
Biological PsychiatrySensory gating deficits in psychiatric impatients: Relation to catecholamine metabolites in different diagnostic groups
114 Citations1990Neil J. Baker, Mary Staunton +6 more
The data suggest that sensory gating deficits are common to these three diagnostic spectra, but the deficits in each group have different relationships to catecholamine metabolism and symptom severity that may reflect differences in the underlying neuronal pathophysiology of these illnesses.
Neuroscience & Biobehavioral ReviewsMeta-analysis and the science of schizophrenia: variant evidence or evidence of variants?
113 Citations2004R. Walter Heinrichs
An argument is developed that biological subtypes and endophenotypes within the broad diagnostic category of schizophrenia underpin the meta-analytic evidence.
NeuropsychobiologyAuditory P50 in Schizophrenics on Clozapine: Improved Gating Parallels Clinical Improvement and Changes in Plasma 3-Methoxy-4-Hydroxyphenylglycol
105 Citations1999Herbert T. Nagamoto, Lawrence E. Adler +6 more
Evidence is provided that improved P50 gating in schizophrenic patients treated with clozapine coincides with clinical improvement and that this improvement can be sustained for at least 1 year.
Schizophrenia ResearchContributions of subtype and spectral frequency analyses to the study of P50 ERP amplitude and suppression in schizophrenia
88 Citations2005Jason Johannesen, Paul D. Kieffaber +4 more
ERP deficits in the dual-click paradigm were specific to S1 amplitudes and most prominent in the low frequency response, and extend their relevance to schizophrenia subtype distinctions.
Biological PsychiatryAmphetamine disrupts P50 suppression in normal subjects
83 Citations1999Gregory A. Light, Dolores Malaspina +5 more
The data indicate that amphetamine induces a disruption of P50 suppression in normal subjects, consistent with several careful examinations of suppression deficits in rodent models that have identified the monoaminergic regulation of P 50 suppression.
American Journal of PsychiatryVaried Effects of Atypical Neuroleptics on P50 Auditory Gating in Schizophrenia Patients
81 Citations2004Lawrence E. Adler
American Journal of PsychiatryA Concordance Study of Three Electrophysiological Measures in Schizophrenia
76 Citations2005Sandrine Louchart-de la Chapelle, Irène Nkam +12 more
Despite superficial similarities, two paradigms designed to measure central inhibition processes (antisaccade and P50 inhibition) do not appear to reflect the same neurobiological substrates and convergence in performance data for the antisaccades and eye tracking paradigsms suggests that the neural circuitry underlying these tasks may overlap.
American Journal of Medical GeneticsSensory gating deficits in parents of schizophrenics
74 Citations1995Merilyne C. Waldo, Marina Myles‐Worsley +3 more
Loss of gating of the auditory P50 wave as an inherited deficit related to schizophrenia is supported and studies of parents may help elucidate the neurobiological expression of genes that convey risk for schizophrenia.
American Journal of Medical GeneticsQuantitative neural indicators of liability to schizophrenia: Implications for molecular genetic studies
56 Citations2001Tyrone D. Cannon, Timothy L. Gasperoni +2 more
There are likely to be multiple heritable dimensions of the central nervous system pathology in schizophrenia, each under the influence of a partially distinct set of genes, one of which involves disturbances in the structure and functioning of frontal lobe systems involved in working memory and another of which appears to render the brain more susceptible to damage to subcortical systems involved with long-term memory following oxygen deprivation in utero.
Clinical Neuroscience ResearchSensory gating deficits in schizophrenia: can we parse the effects of medication, nicotine use, and changes in clinical status?
52 Citations2003Gregory A. Light, David Braff
The literature on gating deficits across the schizophrenia spectrum and the reported effects of nicotine and medications on P50 suppression and PPI is reviewed and productive strategies for ‘parsing’ specific medication effects on Gating deficits are discussed.
American Journal of PsychiatryOlanzapine Effects on Auditory Sensory Gating in Schizophrenia
47 Citations2003Celso Arango, Ann Summerfelt +1 more
It is suggested that there is not a significant differential effect of olanzapine and haloperidol on the P50 sensory gating index in schizophrenia.
American Journal of Medical Genetics Part B Neuropsychiatric GeneticsGenetic overlap between P300, P50, and duration mismatch negativity
47 Citations2006Mei‐Hua Hall, Katja Schulze +4 more
The present study used multivariate genetic model fitting analytic techniques in 46 monozygotic and 32 dizygotic twin pairs to evaluate different brain information processing functions that may be mediated by distinct neurobiological mechanisms which in turn are influenced by different sets of genes.
International Review of PsychiatryCan biological markers identify endophenotypes predisposing to schizophrenia?
35 Citations1997Harvey Wickham, Robin Murray
Studies that have evaluated the use of the following to identify biological markers of schizophrenia: structural neuroimaging, neuropsychological deficits, neurological signs, eye tracking, eventrelated potentials, and minor physical anomalies are reviewed.
Multivariate Behavioral ResearchMultilevel Modeling of Cognitive Function in Schizophrenic Patients and Their First Degree Relatives
28 Citations2001Sophia Rabe‐Hesketh, Timothea Toulopoulou +1 more
Multilevel modeling of cognitive function in subjects with schizophrenia, their healthy first degree relatives and controls is described and penalized quasilikelihood estimates for a binomial response were compared with estimates obtained using Gaussian quadrature.
Psychiatry ResearchCocaine use and the mid-latency auditory evoked responses
27 Citations2000Nashaat N. Boutros, Duane Campbell +4 more
The authors' data suggest that cocaine-dependent subjects generate smaller P50 components when long ISIs are used with multiple repetitions (in the trains paradigm) and in a single repetition paradigm (paired clicks), a significant decrease in the ability to attenuate the N100 component was seen in the cocaine- dependent subjects.
Psychiatric Clinics of North AmericaRecent Findings on the Genetic Basis of Bipolar Disorder
18 Citations2005Jennifer L. Payne, James B. Potash +1 more
The most recent findings and the emerging picture in the genetics of bipolar disorder are reviewed.
Biological PsychiatryLithium alters measures of auditory gating in two strains of mice
17 Citations2003Heidi C. O’Neill, Mischel P. Schmitt +1 more
DBA/2 mice showed improved auditory gating following lithium treatment, likely due to improved functioning of the gamma-aminobutyric acid system, while the C3H mice, the benchmark "normal" mouse strain, were impaired after lithium treatment.